Bioactivity Evaluation and Phytochemical Characterization of Euonymus alatus (Thunb.) Siebold Leaf Extract DOI Creative Commons
Weon‐Jong Yoon, Hye-Ji Min, Hyun‐Dong Cho

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(12), P. 2928 - 2928

Published: Dec. 23, 2024

Background: Euonymus alatus (E. alatus) has traditionally been used for medicinal purposes, and its leaves are considered edible. While E. is known diverse biological activities, the antioxidant, antidiabetic, anticancer effects of extracted using different solvents have not thoroughly investigated. Methods: This study examined anticancer, life-prolonging leaf extract. Results: The phytochemical analysis showed that ethanol extract contained highest levels polyphenols (347.2 mg/mL) flavonoids (317.7 compared to water methanol extracts. In addition, specific phenolics, such as rutin, ellagic acid, quercetin, were found in Antioxidant assays exhibited superior DPPH, ABTS radical, H2O2-scavenging well reducing power. displayed strong α-glucosidase inhibitory activity a dose-dependent manner. cancer cell studies, selectively inhibited proliferation MDA-MB-231 (breast) LNCaP (prostate) cells without affecting normal cells. Apoptosis induction was confirmed by nuclear condensation increased caspase-3 activity. Furthermore, treatment with 30 mg/kg/day extended lifespan tumor-bearing mice 50 days, no fatalities, indicating protective effect. Conclusions: potential an agent.

Language: Английский

Gallic acid enhances memory, learning and reduces neuroinflammation in a rat model of scopolamine-induced cholinergic dysfunction DOI

Mahbobe Alikhanzade,

Maryam Khosravi,

Mahmoud Hosseini

et al.

Inflammopharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: March 16, 2025

Language: Английский

Citations

0
Exploring the Antioxidative Mechanisms of Medicinal Plants in Combating Age-Related Brain Decline DOI Creative Commons

Mugo Moses H.

Brain Science Advances, Journal Year: 2024, Volume and Issue: 10(3)

Published: July 1, 2024

Language: Английский

Citations

0
Unveiling the Medicinal Potential of Euonymus alatus (Thunb.) Siebold: From Traditional Knowledge to Mechanistic Understanding DOI
Acharya Balkrishna, P. Kaur, Deepika Srivastava

et al.

Pharmacological Research - Natural Products, Journal Year: 2024, Volume and Issue: 5, P. 100102 - 100102

Published: Oct. 5, 2024

Language: Английский

Citations

0
Bioactivity Evaluation and Phytochemical Characterization of Euonymus alatus (Thunb.) Siebold Leaf Extract DOI Creative Commons
Weon‐Jong Yoon, Hye-Ji Min, Hyun‐Dong Cho

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(12), P. 2928 - 2928

Published: Dec. 23, 2024

Background: Euonymus alatus (E. alatus) has traditionally been used for medicinal purposes, and its leaves are considered edible. While E. is known diverse biological activities, the antioxidant, antidiabetic, anticancer effects of extracted using different solvents have not thoroughly investigated. Methods: This study examined anticancer, life-prolonging leaf extract. Results: The phytochemical analysis showed that ethanol extract contained highest levels polyphenols (347.2 mg/mL) flavonoids (317.7 compared to water methanol extracts. In addition, specific phenolics, such as rutin, ellagic acid, quercetin, were found in Antioxidant assays exhibited superior DPPH, ABTS radical, H2O2-scavenging well reducing power. displayed strong α-glucosidase inhibitory activity a dose-dependent manner. cancer cell studies, selectively inhibited proliferation MDA-MB-231 (breast) LNCaP (prostate) cells without affecting normal cells. Apoptosis induction was confirmed by nuclear condensation increased caspase-3 activity. Furthermore, treatment with 30 mg/kg/day extended lifespan tumor-bearing mice 50 days, no fatalities, indicating protective effect. Conclusions: potential an agent.

Language: Английский

Citations

0