Evolving from organoid to assembloid with enhanced cellular interactions

Cell organoid (Print), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

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The Alleviative Effects of Weizmannia coagulans CGMCC 9951 on the Reproductive Toxicity of Caenorhabditis elegans Induced by Polystyrene Microplastics

Microorganisms, Journal Year: 2025, Volume and Issue: 13(3), P. 497 - 497

Published: Feb. 24, 2025

The increased emission and accumulation of microplastics pose a severe threat to humans the environment. As effective biological agents for alleviating effects microplastics, mechanism action probiotics remains unclear. In this study, based on successful establishment reproductive virulence model Caenorhabditis elegans (C. elegans), we explored effect Weizmannia coagulans CGMCC 9951 (W. 9951) toxicity C. elegans. Our results showed that gonad area number offspring but germ cells undergoing apoptosis decreased by 14% 24% in elegans, after treatments. Antioxidant test activity Superoxide Dismutase (SOD), Catalase (CAT), content Glutathione (GSH) addition, it was found qPCR mutagenesis experiments verified alleviated through DNA checkpoint signaling pathway. findings suggested could alleviate polystyrene enhancing antioxidant capacity inhibiting damage above suggest can be used as potential approach induced humans.

Language: Английский

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Effects of magnolol on the liver antioxidant status in rats with diabetes

Pharmacological Reports, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Language: Английский

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Agomelatine Alleviates Depressive-like Behaviors by Suppressing Hippocampal Oxidative Stress in the Chronic Social Defeat Stress Model

Antioxidants, Journal Year: 2025, Volume and Issue: 14(4), P. 410 - 410

Published: March 28, 2025

Major depressive disorder (MDD) is a common psychiatric characterized by significant mood disturbances and cognitive impairments. Chronic stress, particularly social defeat plays crucial role in the etiology of depression, with oxidative stress being pivotal factor its pathophysiology. Consequently, identifying effective strategies to mitigate prevent progression depression paramount importance. Agomelatine, an atypical antidepressant melatonergic serotonergic properties, has shown promise treating MDD due unique mechanisms action. In this study, we aimed investigate whether agomelatine could ameliorate behavioral deficits chronic (CSDS) mouse model. CSDS mice were administered (50 mg/kg, intraperitoneally) exhibited reductions both anxiety-like depressive-like behaviors tests. Further analysis revealed that treatment effectively reduced damage hippocampus mice. Additionally, attenuated mitochondrial dysfunction restored synaptic plasticity, as evidenced increased density excitatory synapses enhanced neuronal activity. These findings suggest may exert therapeutic effects reducing preserving function, enhancing providing new insights into potential for stress-induced depression.

Language: Английский

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Effect of dietary carnosine during in vitro digestion of a burger meal combo model including ascorbic acid as an antioxidant and fructose as a pro‐oxidant

Journal of Food Science, Journal Year: 2025, Volume and Issue: 90(4)

Published: April 1, 2025

Abstract Carnosine, as a meat constituent, was previously shown to exhibit some pro‐oxidative effects during in vitro digestion of burger meal model the presence high (supplemental) level ascorbic acid (AA). In current study, dietary carnosine were assessed combo model, including intrinsic (low, LCar) and enriched (intermediate, MCar; high, HCar) ground pork, with or without levels AA and/or fructose simulated beverages. Increased (MCar showed antioxidant activity, irrespective phase AA. At level, generally acted an antioxidant, but promoted formation glyoxal (GO) gastric digests malondialdehyde (MDA) hexanal duodenal digests. Fructose pro‐oxidant effect, decreased MDA GO concentrations both phases. Despite higher bio‐accessible measured HCar, which potentially represents additional health benefits post absorption, MCar treatment provided optimal activity further obtained at HCar showing ceiling‐like effect digestive environment vitro. These results demonstrate potential advantages increased despite other redox‐active compounds suggest hormetic can occur digestion. Practical Application multifunctional compound naturally present meat, bring considerable consumers. reduced oxidation advanced glycation end products (AGEs) either (AA) (as antioxidant) pro‐oxidant). context this attained intermediate enhancement be through breeding nutrition.

Language: Английский

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Rhapontin activates nuclear factor erythroid 2-related factor 2 to ameliorate 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced gastrointestinal dysfunction in Parkinson's disease mice

World Journal of Gastroenterology, Journal Year: 2025, Volume and Issue: 31(15)

Published: April 17, 2025

Parkinson's disease (PD)-a progressive neurodegenerative disorder-is characterized by motor and gastrointestinal dysfunction. The exploration of novel therapeutic strategies for PD is vital. To investigate the potential mechanism action rhapontin-a natural compound with known antioxidant anti-inflammatory properties-in context PD. Network pharmacology was used to predict targets mechanisms rhapontin in Behavioral tests tyrosine hydroxylase immunofluorescence analysis were assess effect on symptoms pathology MPTP-induced mice. Interleukin (IL)-6, IL-1β, tumor necrosis factor (TNF)-α, IL-10 levels tissues measured using an enzyme-linked immunosorbent assay (ELISA). Additionally, nuclear erythroid 2-related 2 (NRF2) activation confirmed western blotting. NRF2 predicted be key transcription underlying effects PD, its anti-PD may associated properties. Rhapontin ameliorated loss dopaminergic neurons dysfunction 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mice activating NRF2. treatment significantly decreased pro-inflammatory cytokines (IL-6, TNF-α, IL-1β) substantia nigra, striatum, colon, whereas it increased cytokine (IL-10) only indicating involvement gut-brain axis neuroprotective potential. Finally, identified as a activated rhapontin, particularly colon. We elucidated mouse models combination network analysis, behavioral assessments, immunofluorescence, ELISA, Western Our findings revealed multifaceted role ameliorating through properties, NRF2, paving way future research into targeted therapies

Language: Английский

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Molecular Mechanisms Contributing to the Impairment of Steroid Hormones, Sperm Characteristics, and Testicular Architecture in Male Rabbits After Chronic Exposure to Cadmium: Role of Gallic Acid and Selenium as Antioxidants

Toxics, Journal Year: 2025, Volume and Issue: 13(4), P. 323 - 323

Published: April 21, 2025

One hazardous material that occurs naturally in the environment and induces oxidative stress is cadmium (Cd). Epidemiological data revealed exposure to workplace might be linked many illnesses serious testicular injuries. Aims: It taught antioxidants can protect different organs against environmental toxic compounds. Therefore, current investigation aims show role of (gallic acid selenium) protection toxicity, including architecture testes, semen properties, steroid hormones, protein expression cytochrome P450 [CYP 19 11A1] contributing production antioxidant enzyme activities, male rabbits. Methods: Male rabbits were given orally three times/week [1 mg/kg BW] for twelve weeks. In addition, gallic (20 mg/kg) or selenium (1 BW) was administered two hours before treatment. This included a spectrophotometer, histopathology, Western immunoblotting techniques. Results: Cadmium treatment significantly reduced sperm counts, testosterone, estrogen levels after four, eight, weeks 12-week with cadmium, activity 17β-hydroxysteroid dehydrogenase enzymes, catalase, superoxide dismutase, glutathione reductase, peroxidase, S-transferase, as well levels, inhibited testes tissue. On other hand, following treatment, rabbit’s showed discernible increase free radical levels. Interestingly, enzymes level radicals recovered treated 12 steroidogenic expressions CYP 11A1 upregulated downregulated respectively. pretreatment either administration, CYP11A1 restored normal histopathological investigation, immature spermatozoids sloughed spermatogonium cells observed cadmium-treated rabbits’ testes. pretreatments mitigated alleviated adverse effects on increased healthy sperm. Conclusions: The lower hormones could due downregulation CYP11A1, inhibition dehydrogenase, induction Furthermore, tissue hormone

Language: Английский

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Supporting Neurologic Health with Mushroom Nutrition

Nutrients, Journal Year: 2025, Volume and Issue: 17(9), P. 1568 - 1568

Published: May 2, 2025

Due to the extensive types of etiologies and risks causing over 600 mental health issues, convene adequate recommendations in primary care is a difficult assignment. The starting point for preventive interventions on neurologic disorders involves scrutinizing risk factors while targeting multiple hazards order increase success an early precautionary mediation plan action. factor most neurodegenerative diseases increasing worldwide median age, although one seven youngsters also experience disability, namely depression, representing decline well-being conferring considerable global public challenge. brain operates optimally when supported by holistic approach engaging several aspects, diet becoming integral part strategies. Treatment presently dominated pharmacotherapy, but additional strategies are needed prevent treat disorders. Dietary modification can prove be cost-effective strategy prevention and, certain conditions, treatment neurological Molecules dietary ingredients, micronutrients, phytonutrients, additives may modulate depression associated biomarkers. Nutritional exposure during developmental stages maternal impact, lifestyles, modulation gut microbiota through as novel therapies various neuropsychiatric conditions gaining interest maintaining health. Bioactive substances present different mushroom species have been ascribed both direct indirect mechanisms influence neurobehavior, here we support recognition nutrition influential element management some concerns. Scientific evidence demonstrating unequivocal link between nutritional mushrooms cognitive only beginning emerge, medicine should considered care.

Language: Английский

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The Evidence for Diet as a Treatment in Migraine—A Review

Nutrients, Journal Year: 2024, Volume and Issue: 16(19), P. 3415 - 3415

Published: Oct. 9, 2024

Background/objectives: The connection between diet and migraine has gained increasing attention in research due to its potential relevance as part of treatment. This study reviewed the current evidence on use diets or specific foods prevention migraine. Methods: A PubMed search was performed with keywords “diet migraine” OR “brain-gut-axis migraine”. One author (KVN) screened titles, abstracts, full-text articles excluded included them based eligibility criteria. Results: ketogenic a “Dietary Approaches Stop Hypertension” reduced attack duration (p < 0.002), frequency 0.05), severity 0.01). also monthly medication intake ≤ 0.05). low-fat vegan mixed an elimination 0.01), 0.0001), percentage medicated headaches 0.001). Elimination 0.02), 0.002). IgG-positive 0.001), total Gluten-free = 0.02) 0.013). Conclusions: Certain food items may trigger attacks some patients, though overall supporting this is limited. Modifying reduce symptoms such duration, frequency, severity, intake. However, studies’ small populations diverse designs make results difficult apply clinical practise. Further high-quality, double-blinded, randomised controlled trials are necessary confirm association

Language: Английский

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Nrf2/Keap1/ARE regulation by plant secondary metabolites: a new horizon in brain tumor management

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: Oct. 15, 2024

Brain cancer is regarded as one of the most life-threatening forms worldwide. Oxidative stress acts to derange normal brain homeostasis, thus involved in carcinogenesis brain. The Nrf2/Keap1/ARE pathway an important signaling cascade responsible for maintenance redox and regulation anti-inflammatory anticancer activities by multiple downstream pathways. Interestingly, Nrf2 plays a somewhat, contradictory role cancers, including cancer. has traditionally been tumor suppressor since its cytoprotective functions are considered be principle cellular defense mechanism against exogenous endogenous insults, such xenobiotics oxidative stress. However, hyperactivation supports survival well malignant cells, protecting them stress, therapeutic agents. Plants possess pool secondary metabolites with potential chemotherapeutic/chemopreventive actions. Modulation Nrf2/ARE Keap1-dependant manner, aid plant-derived exhibits promise management tumors. Current article highlights effects on tumors, regarding same.

Language: Английский

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