Crosstalk Between Antioxidants and Adipogenesis: Mechanistic Pathways and Their Roles in Metabolic Health

Antioxidants, Journal Year: 2025, Volume and Issue: 14(2), P. 203 - 203

Published: Feb. 10, 2025

The interplay between oxidative stress and adipogenesis is a critical factor in the development of obesity its associated metabolic disorders. Excessive reactive oxygen species (ROS) disrupt key transcription factors such as peroxisome proliferator-activated receptor gamma (PPARγ) CCAAT/enhancer-binding protein alpha (C/EBPα), impairing lipid metabolism, promoting adipocyte dysfunction, exacerbating inflammation insulin resistance. Antioxidants, classified endogenous (e.g., glutathione, superoxide dismutase, catalase) exogenous polyphenols, flavonoids, vitamins C E), are pivotal mitigating these effects by restoring redox balance preserving functionality. Endogenous antioxidants neutralize ROS safeguard cellular structures; however, under heightened stress, defenses often insufficient, necessitating dietary supplementation. Exogenous derived from plant-based sources, polyphenols vitamins, act through direct scavenging, upregulation antioxidant enzymes, modulation signaling pathways like nuclear kappa B (NF-κB) PPARγ, reducing peroxidation, inflammation, dysfunction. Furthermore, they influence epigenetic regulation transcriptional networks to restore differentiation limit accumulation. Antioxidant-rich diets, including Mediterranean diet, strongly with improved health, reduced rates, enhanced sensitivity. Advances personalized therapies, guided biomarkers supported novel delivery systems, present promising avenues for optimizing therapeutic interventions. This review, "Crosstalk Between Antioxidants Adipogenesis: Mechanistic Pathways Their Role Metabolic Health", highlights mechanistic which regulate enhance health.

Language: Английский

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Resveratrol: A Review on the Biological Activity and Applications

Applied Sciences, Journal Year: 2024, Volume and Issue: 14(11), P. 4534 - 4534

Published: May 25, 2024

Resveratrol (RSV), a naturally occurring phytoalexin, is the most important stilbenoid synthesized by plants as defense mechanism in response to microbial aggression, toxins, or ultraviolet radiation. RSV came attention of researchers both potential chemopreventive agent and possible explanation for low incidence cardiovascular disease (CVD) French people with high-fat diet. mainly administered food supplement, its properties are evaluated vitro vivo on various experimental models. modulates signaling pathways that limit spread tumor cells, protects nerve cells from damage, useful prevention diabetes, generally acts an anti-aging natural compound. It was highlighted could ameliorate consequences unhealthy lifestyle caused exaggerated caloric intake. This paper reviews evidence supporting beneficial effect pathological conditions, e.g., neoplastic diseases, neurodegeneration, metabolic syndrome, obesity, CVDs, immune bacterial, viral, fungal infections. The study also focused chromatographic analysis trans-RSV (tRSV) Romanian wine samples, providing comprehensive overview tRSV content across different types wine.

Language: Английский

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Therapeutic potential and agricultural benefits of curcumin: a comprehensive review of health and sustainability applications

Journal of Umm Al-Qura University for Applied Sciences, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 5, 2024

Abstract Turmeric ( Curcuma longa L.), the plant from which curcumin is derived, renowned for its wide range of therapeutic and agricultural benefits. Curcumin, key bioactive compound, highly valued potent anti-provocative, antioxidant, antimicrobial properties, contribute to effectiveness in treating various human diseases improving resilience environmental stresses. The therapeutics potential notable owing abilities combat microbes act as an oxidant reduce inflammation. Its a disease such tumor, cardiac problems, brain degenerative ailments stems ability modulate cellular process signaling pathways. Despite low bioavailability, innovations delivery system nanoparticles liposomal formulations, have enhanced efficacy by solubility systemic absorption. In agriculture, curcumin's properties provide natural alternative chemical pesticides, offering protection against pathogens enhancing specific stresses drought, salinity, oxidative stress. Nanotechnology applications furthered these benefits facilitating efficient uptake distribution within tissues, promoting growth stress tolerance. This review also highlights nutritional benefits, including impact on gut health metabolic syndrome. Synergistic interactions with dietary nutrients can amplify making it valuable supplement. However, ongoing research needed fully understand mechanisms action long-term safety. Overall, holds promise versatile agent both medical fields, supporting sustainable practices advancing outcomes. Future should focus optimizing formulations translating preclinical findings into clinical successes. Graphical abstract

Language: Английский

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Diabetic Nephropathy: Pathogenesis, Mechanisms, and Therapeutic Strategies

Hormone and Metabolic Research, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 21, 2024

Abstract Diabetic nephropathy represents a predominant etiology of end-stage renal disease (ESRD) on global scale, significantly impacting the morbidity and mortality rates individuals with diabetes. The primary objective this analysis is to furnish comprehensive examination etiology, fundamental mechanisms, treatment modalities for DN. development DN stems from multitude factors, encompassing intricate interplay involving metabolic irregularities induced by hyperglycemia, alterations in hemodynamics, inflammatory responses, oxidative stress, genetic susceptibility. Principal mechanisms encompass generation advanced glycation end products (AGEs), activation protein kinase C (PKC), overexpression renin-angiotensin-aldosterone system (RAAS). These processes precipitate glomerular hyperfiltration, hypertrophy, eventually, fibrosis scarring parenchyma. Initially, hyperglycemia triggers mesangial proliferation thickening basement membrane incipient stages DN, subsequently leading progressive sclerosis tubulointerstitial fibrosis. Inflammatory cascades, notably cytokines like TGF-β NF-κB, play pivotal roles advancement fostering accumulation extracellular matrix Inflammation pathways, particularly those essential diabetic progression stimulating presence worsened dysfunctional mitochondria, contributes further injury via lipid peroxidation DNA damage. Current therapeutic approaches concentrate optimizing glycemic control, controlling hypertension, suppressing system. Among antihypertensive medications, ACE inhibitors angiotensin II receptor blockers are crucial decelerating advancement.

Language: Английский

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The efficacy of resveratrol supplementation on inflammation and oxidative stress in type-2 diabetes mellitus patients: randomized double-blind placebo meta-analysis

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 13, 2025

Background The effects of resveratrol supplementation on inflammation and oxidative stress in patients with type 2 diabetes mellitus (T2DM) were controversial. A meta-analysis was performed to assess the changes levels T2DM. Methods Relevant literatures before November 6, 2024 screened through Web Science,Embase,the Cochrane Library other sources (ClinicalTrials, ProQuest Dissertations Theses). quality literature evaluated according Handbook Systematic Reviews. study assessed using risk-of-bias tool Grading Recommendations Assessment,Development Evaluation (GRADE) system. Review Manager 5.3 conducted data included literature. Results This six randomized controlled trials involving 533 participants. Our results showed that significantly reduced C-reactive protein levels(SMD = -1.40, 95%CI(-2.60, -0.21), P 0.02; Level evidence: low), lipid peroxide (SMD -0.99, 95%CI(-1.36, -0.61), < 0.00001; 8-isoprostanes(SMD -0.79, 95%CI(-1.16, -0.42), 0.0001; low) score -1.62, 95%CI(-2.49, -0.75), 0.0003; very low). In addition, compared placebo, Supplementation increased glutathione peroxidase 0.38, 95%CI(0.03, 0.74), 0.04; evidence:low) catalase 0.33, 0.63), 0.03; However, no significant difference observed improving interleukin-6 -1.35, 95%CI(-2.75, -0.05), 0.06; tumor necrosis factor α -3.30, 95%CI(-7.47, 0.87), 0.12; superoxide dismutase 0.39, 95%CI(-0.26, 1.04), 0.24; total antioxidant capacity 95%CI(-0.23, 1.00), 0.21; malondialdehyde -3.36, 95%CI(-10.30, 3.09), 0.29; Conclusion Resveratrol improved T2DM some extent. provides a new idea method for clinical treatment. due limitations study, more large-sample, multi-center studies are needed verify this conclusion.

Language: Английский

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Phoenix dactylifera L. (date palm) fruit extracts and fractions exhibit anti-proliferative activity against human pancreatic cancer cell lines

Heliyon, Journal Year: 2025, Volume and Issue: unknown, P. e42274 - e42274

Published: Jan. 1, 2025

Pancreatic cancer has a very poor prognosis due to its high resistance chemotherapeutic drugs, late diagnosis, and early metastasis, making it the most aggressive lethal cancer. Hence, there is pivotal need find new effective preventive curative treatments. In this study, extracted fractions obtained from date palm (Phoenix dactylifera L.) fruit using ethyl acetate n-butanol as solvents. The prepared extracts were pharmacologically evaluated on three pancreatic cell lines: PT45P1, PANC-1, SUIT-2. Specific demonstrated strong anti-proliferative activity. particular Bu-IV was active fraction tested at 500 μg/mL. Moreover, sub-fractions extract inhibited proliferation, especially EA-III-2 50-150 These findings suggest that contain nutraceuticals with potential therapeutic value in treatment of Future work will be focused isolation identification compounds explore their mechanisms action.

Language: Английский

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Characteristics of Resveratrol Tablets Stored Under Stress Conditions by Total Hemispherical Reflectance and Selected Pharmacopoeial Parameters

Processes, Journal Year: 2025, Volume and Issue: 13(3), P. 638 - 638

Published: Feb. 24, 2025

The introduction of medicine into the pharmaceutical market must be preceded by a stability study. One most important reasons for instability drug preparation is improper storage patient, which can accelerate degradation process. In this study, novel directional-hemispherical reflectance (THR) and traditional (hardness friability) methods quality control were used in characteristics resveratrol supplemental tablets exposed to light elevated temperatures. stored an aging chamber at two different temperatures (25 °C, 45 °C) over time intervals (1 h, 3 1 day, 5 days), yielding seven conditions. 410-Solar Reflectometer allowed us determine THR values spectral ranges: 335–380, 400–540, 480–600, 590–720, 700–1100, 1000–1700, 1700–2500 nm. At each point, stress conditions characterized lower all ranges, compared on day 0. Compared 0, significant differences observed 25 °C temperature across entire spectrum studied. change experiment was significantly higher only UVA 335–380 nm range. addition, changes strength parameters tablets, i.e., increase hardness decrease friability found days irrespective temperature. Such after UV heat exposure are probably due homogeneity tablet matrix may indicate possible physical chemical occurring surface or inside tablet.

Language: Английский

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Development and Characterization of Lipid Micro‐ and Nanoparticles for the Encapsulation of Pomegranate Seed Oil

European Journal of Lipid Science and Technology, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

ABSTRACT The aim of this study was to produce and characterize micro‐ nanoparticulate lipid carriers for pomegranate seed oil (PSO) preserve its functional properties. results the dynamic light scattering (DLS) technique revealed that formulation proportions minimally affected particle size, with nanoparticles (LNs) ranging from 308 325 nm, LN4:1 being most monodisperse formulation. Lipid microparticles (LMs) ranged 1251 4364 demonstrating efficiency hot homogenization rotor–stator micrometer‐sized particles. SEM analysis further confirmed morphology, showing well‐defined spherical shapes presence clusters, likely due lyophilization process nature carriers. All formulations exhibited stable dispersion (high negative zeta potential). Formulations greater color difference (Δ E *) a lower polydispersity index (PDI), such as LN4:1, indicate more effective enhanced protection bioactive components. Compatibility preservation PSO characteristics were by XRD FTIR. Encapsulation values 40.0% 66.1%, indicating satisfactory encapsulation. Furthermore, encapsulation effectively protected antioxidant activity PSO, decrease in DPPH scavenging percentage 55.4% (free PSO) 41.4% 51.3% (lipid carriers). Overall, demonstrates feasibility producing methods employed, suggesting applications sustainable packaging. Practical Applications : development micro offers significant potential food industry, particularly creating biodegradable active enhances stability compounds, including punicic acid, tocopherols, polyphenols, protecting them oxidative degradation. This improves shelf life properties products. Additionally, controlled release mechanism these can enhance bioavailability PSO's antioxidants, contributing improved nutritional value health benefits. These findings suggest foods, nutraceuticals, packaging solutions maintain quality safety products over time.

Language: Английский

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Natural Antidiabetic Agents: Current Evidence and Development Pathways from Medicinal Plants to Clinical use

Natural Product Communications, Journal Year: 2025, Volume and Issue: 20(3)

Published: March 1, 2025

Diabetes mellitus is a long-term metabolic condition marked by chronically high levels of glucose in the blood due to insufficient synthesis insulin or impaired function. Throughout history, several civilizations have used traditional medicinal plants treat and control diabetes. This paper offers thorough review, date, antidiabetic natural compounds origin, specifically highlighting their reported modes mechanisms action therapeutic possibilities, with view fast-tracking possibility transition pharmaceutical products for human use. Phytochemicals such as flavonoids, alkaloids, terpenoids, glycosides notable effects. They been shown via many processes, including boosting secretion, improving sensitivity, blocking absorption \gastrointestinal-tract, regulating carbohydrate metabolism. Unlike earlier reviews, this current one, addition chemistry proposed action, also x-rays effectiveness safety these chemicals combining evidences from laboratory research, animal experiments, clinical trials. Several substances, Demethoxycurcumin, Trigonelline, Ginsenosides, progressed trials, while others like Allicin Polypeptide-p at bedside. Bisdemethoxycurcumin, Vicine, Gymnemosides, are now preclinical trial phase, suggesting that research still ongoing there promise future application. The review highlights evolution diabetes management, potential improve treatment. It suggests incorporating plant-derived into treatments, reducing dependence on drugs adverse

Language: Английский

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Effect of Resveratrol and Quercetin on SFRP4 as a Biomarker of Diabesity: In Silico and In Vivo Studies

Biochemical and Biophysical Research Communications, Journal Year: 2025, Volume and Issue: unknown, P. 151748 - 151748

Published: April 1, 2025

Language: Английский

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