Exploring the Role of Thioredoxin system in Cancer Immunotherapy DOI

Lin Sun,

Anni Yu,

Yang Yang

et al.

Journal of Cancer, Journal Year: 2024, Volume and Issue: 16(1), P. 66 - 80

Published: Dec. 11, 2024

Purpose: The thioredoxin (Trx) system is integral to redox regulation and participates in several physiological processes, including tumor growth, immune response, stem cell differentiation. We have performed a comprehensive holistic analysis of the Trx immunity this study. Methods: A study using Human Protein Atlas (HPA) Clinical Proteomic Tumor Analysis Consortium (CPTAC) databases was conducted determine expression distribution proteins. To explore validate correlation between levels progression, GTEx TCGA datasets were used. Western blotting used measure lung cancer lines, while MTT assays proliferation. Kaplan-Meier plotter database association survival outcome patients pan-cancer. GO KEGG enrichment analyses performed. Next, we analyzed how related activation. Using TIDE TISMO databases, predicted immunotherapy responses. Results: An abnormal observed cells. Interference with siRNA or inhibitors significantly inhibits suggesting crucial growth. Through broad cohort different types, explored prominent role genes system. showed relatively consistent aberrant pan-cancer, correlated closely clinical prognosis. Interestingly, highly prognosis as well metabolism. positively associated infiltration decrease survival. also response immunotherapy. Conclusion: good predictor both efficacy immunotherapy,

Language: Английский

Oxidative Stress and the NLRP3 Inflammasome: Focus on Female Fertility and Reproductive Health DOI Creative Commons
Efthalia Moustakli,

Sofoklis Stavros,

Periklis Katopodis

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(1), P. 36 - 36

Published: Jan. 2, 2025

Chronic inflammation is increasingly recognized as a critical factor in female reproductive health; influencing natural conception and the outcomes of assisted technologies such vitro fertilization (IVF). An essential component innate immunity, NLR family pyrin domain-containing 3 (NLRP3) inflammasome one major mediators inflammatory responses, its activation closely linked to oxidative stress. This interaction contributes decline oocyte quality, reduced potential, impaired embryo development. In ovarian milieu, stress NLRP3 interact intricately, their combined effects on competence are significant. The aims this review examine these molecular mechanisms explore therapeutic strategies targeting activity, with goal enhancing fertility improving clinical health.

Language: Английский

Citations

1
Glutathione and biosensor technologies: enhancing plant resilience to environmental stressors DOI

Anjuman Ayub,

Farida Rahayu, Amel Gacem

et al.

Physiological and Molecular Plant Pathology, Journal Year: 2025, Volume and Issue: unknown, P. 102570 - 102570

Published: Jan. 1, 2025

Language: Английский

Citations

1
Adolescent gut microbiome imbalance and its association with immune response in inflammatory bowel diseases and obesity DOI Creative Commons

Minjae Joo,

Seungyoon Nam

BMC Microbiology, Journal Year: 2024, Volume and Issue: 24(1)

Published: July 19, 2024

Abstract Background Recently, there has been an increase in the number of studies focusing on association between gut microbiome and obesity or inflammatory diseases, especially adults. However, is a lack investigating gastrointestinal (GI) diseases adolescents. Method We obtained 16S rRNA-seq datasets for analysis from 202 adolescents, comprising ulcerative colitis (UC), Crohn’s disease (CD), (Ob), healthy controls (HC). utilized Quantitative Insights Into Microbial Ecology (QIIME) Phylogenetic Investigation Communities by Reconstruction Unobserved States (PICRUSt) to acquire Operational Taxonomic Units (OTUs). Subsequently, we analyzed Kyoto Encyclopedia Genes Genomes (KEGG) Orthology (KO) terms pathway enrichment identified OTUs. Results In this study, investigated difference microbiomes adolescents with GI those using samples rRNA sequencing data. The distribution six main microbiota (i.e., unclassified Dorea , Lachnospiraceae Ruminococcus Faecalibacterium prausnitzii Prevotella copri Sutterella ) was different based status diseases. Dysbiosis observed within UC CD), . More specifically, our results showed that relative abundance more than 10% 8% higher, respectively, group compared CD, Ob, HC groups. Additionally, Ob had over 20% 3% higher levels UC, Also, inspecting associations specific KO terms, found -relating were associated NOD-like receptor signaling. These taxa differences may affect immune system response affecting signaling host during critical adolescence. Conclusion discovered dysbiosis microbial community varying degrees influence pathways obesity.

Language: Английский

Citations

2
Antibacterial activity of engineered nanoparticles against fish pathogens DOI Creative Commons
Edith Dube

Aquaculture Reports, Journal Year: 2024, Volume and Issue: 37, P. 102240 - 102240

Published: July 8, 2024

Language: Английский

Citations

1
Chromosomal Type II Toxin–Antitoxin Systems May Enhance Bacterial Fitness of a Hybrid Pathogenic Escherichia coli Strain Under Stress Conditions DOI Creative Commons
Jessika C. A. Silva, Lázaro Moreira Marques Neto, Enéas Carvalho

et al.

Toxins, Journal Year: 2024, Volume and Issue: 16(11), P. 469 - 469

Published: Nov. 1, 2024

The functions of bacterial plasmid-encoded toxin-antitoxin (TA) systems are unambiguous in the sense controlling cells that fail to inherit a plasmid copy. However, its role chromosomal copies is contradictory, including stress-response-promoting fitness and antibiotic treatment survival. A hybrid pathogenic

Language: Английский

Citations

1
Diltiazem mitigates acute liver injury by targeting NFκB-TXNIP/NLRP3 axis in Rats: New insights beyond calcium channel blockade DOI

Fatma Elnaghy,

George S.G. Shehatou,

Eman M. Abd El-Kader

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 143, P. 113460 - 113460

Published: Nov. 7, 2024

Language: Английский

Citations

0
Exploring the Role of Thioredoxin system in Cancer Immunotherapy DOI

Lin Sun,

Anni Yu,

Yang Yang

et al.

Journal of Cancer, Journal Year: 2024, Volume and Issue: 16(1), P. 66 - 80

Published: Dec. 11, 2024

Purpose: The thioredoxin (Trx) system is integral to redox regulation and participates in several physiological processes, including tumor growth, immune response, stem cell differentiation. We have performed a comprehensive holistic analysis of the Trx immunity this study. Methods: A study using Human Protein Atlas (HPA) Clinical Proteomic Tumor Analysis Consortium (CPTAC) databases was conducted determine expression distribution proteins. To explore validate correlation between levels progression, GTEx TCGA datasets were used. Western blotting used measure lung cancer lines, while MTT assays proliferation. Kaplan-Meier plotter database association survival outcome patients pan-cancer. GO KEGG enrichment analyses performed. Next, we analyzed how related activation. Using TIDE TISMO databases, predicted immunotherapy responses. Results: An abnormal observed cells. Interference with siRNA or inhibitors significantly inhibits suggesting crucial growth. Through broad cohort different types, explored prominent role genes system. showed relatively consistent aberrant pan-cancer, correlated closely clinical prognosis. Interestingly, highly prognosis as well metabolism. positively associated infiltration decrease survival. also response immunotherapy. Conclusion: good predictor both efficacy immunotherapy,

Language: Английский

Citations

0