The association of vitamin deficiency with depression risk in late-life depression: a review DOI Creative Commons
Yao Gao, Xiaona Song, Z. G. Wen

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: April 15, 2025

Late-life depression (LLD), a growing public health challenge in aging societies, profoundly impacts physical and mental by exacerbating cognitive decline, functional disability, comorbid chronic diseases. Emerging research highlights vitamin supplementation as promising adjunctive therapy for LLD, targeting its multifactorial pathogenesis involving mitochondrial dysfunction, neuroinflammation, oxidative stress. Specific vitamins, including B-complex vitamins (B1, B6, B9, B12), D, antioxidants (C, E), demonstrate therapeutic potential through mechanisms ranging from neurotransmitter regulation to function enhancement. For instance, D modulates serotonin synthesis calcium signaling, while B mitigate homocysteine-mediated neurotoxicity support energy metabolism. Antioxidants counteract neural damage linked depressive severity. Clinical studies reveal that deficiency (<20 ng/mL) correlates with elevated risk, combined B-vitamin shows symptom alleviation nutritionally deficient subgroups. However, evidence remains heterogeneous due variability dosing protocols, bioavailability, population-specific factors like comorbidities. Despite evidence, critical gaps persist regarding optimal dosages, bioavailability variations, long-term outcomes elderly populations. This review synthesizes current on vitamin-mediated cellular pathways LLD management, evaluates clinical efficacy across interventions, proposes personalized nutritional strategies optimize outcomes. By integrating mechanistic insights data, this analysis aims guide evidence-based protocols within geriatric care frameworks.

Language: Английский

Association between dietary patterns and suicide ideation among depressed adults: Insights from NHANES 2007–2020 DOI
Kun Li,

Honggang Lyu,

Lihong Zhang

et al.

Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: 377, P. 235 - 244

Published: Feb. 21, 2025

Language: Английский

Citations

1
The association of vitamin deficiency with depression risk in late-life depression: a review DOI Creative Commons
Yao Gao, Xiaona Song, Z. G. Wen

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: April 15, 2025

Late-life depression (LLD), a growing public health challenge in aging societies, profoundly impacts physical and mental by exacerbating cognitive decline, functional disability, comorbid chronic diseases. Emerging research highlights vitamin supplementation as promising adjunctive therapy for LLD, targeting its multifactorial pathogenesis involving mitochondrial dysfunction, neuroinflammation, oxidative stress. Specific vitamins, including B-complex vitamins (B1, B6, B9, B12), D, antioxidants (C, E), demonstrate therapeutic potential through mechanisms ranging from neurotransmitter regulation to function enhancement. For instance, D modulates serotonin synthesis calcium signaling, while B mitigate homocysteine-mediated neurotoxicity support energy metabolism. Antioxidants counteract neural damage linked depressive severity. Clinical studies reveal that deficiency (<20 ng/mL) correlates with elevated risk, combined B-vitamin shows symptom alleviation nutritionally deficient subgroups. However, evidence remains heterogeneous due variability dosing protocols, bioavailability, population-specific factors like comorbidities. Despite evidence, critical gaps persist regarding optimal dosages, bioavailability variations, long-term outcomes elderly populations. This review synthesizes current on vitamin-mediated cellular pathways LLD management, evaluates clinical efficacy across interventions, proposes personalized nutritional strategies optimize outcomes. By integrating mechanistic insights data, this analysis aims guide evidence-based protocols within geriatric care frameworks.

Language: Английский

Citations

0