Foods, Journal Year: 2024, Volume and Issue: 13(24), P. 4103 - 4103

Published: Dec. 18, 2024

The increase in the incidence of hyperglycemia and diabetes poses challenge finding cost-effective natural inhibitors starch digestion enzymes. Among compounds, phenolics have been considered as promising candidates. aims this study were follows: (a) to investigate effectiveness inhibition different winemaking byproducts towards intestinal brush border α-glucosidase pancreatic α-amylase vitro; (b) calculate an efficacy index relative standard acarbose for phenolic pool byproducts, well isolated compounds pools plants studied literature, order rank with respect reference drug other alternatives. red grape skins showed highest inhibitory activities both α-amylase, which were, on average, 4.9 2.6 µg equivalents/µg total (µg Ac eq/µg GAE), respectively. A correlation was observed between contents their effectiveness, is useful standardizing extracts obtained from processes. In general, activity higher than those namely anthocyanins monomeric polymeric flavanols flavonols, probably due synergistic effects among compounds. Hence, bioactive fractions could be produced focus functionality rather purity, line principles sustainable processing. Based developed compare phenolic-rich literature enzyme inhibitors, proved

Language: Английский