Surgical Management of Pediatric Obstructive Sleep Apnea: Efficacy, Outcomes, and Alternatives—A Systematic Review DOI Creative Commons
Gianna Dipalma, Angelo Michele Inchingolo, Irene Palumbo

et al.

Life, Journal Year: 2024, Volume and Issue: 14(12), P. 1652 - 1652

Published: Dec. 12, 2024

Aim: Obstructive sleep apnea (OSA) is the most prevalent sleep-related breathing disorder. OSA affects approximately 2 million Italians, although only 3% receive a diagnosis and correct treatment. This review aims to provide an overview guide clinical decision making, ensuring that patients appropriate treatment for their specific condition. Material Methods: systematic was conducted according Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA) guidelines registered at PROSPERO under ID CRD42024593760. A search on PubMed, Scopus, Web of Science performed find papers matched topic, using following Boolean keywords: (“obstructive apnea” OR “OSA” “sleep apnea, obstructive”) AND (“surgery” “surgical” “surgical techniques” treatment” “operative” procedures”) (“treatment” “therapy” “management”). Result: The electronic database found 20337 publications. After screening eligibility phase, 15 were chosen qualitative analysis. Conclusions: Adenotonsillectomy (AT) significantly improves secondary outcomes like behavioral issues quality life, compared watchful waiting with supportive care (WWSC). Alternative approaches such as tonsillotomy adenopharyngoplasty (APP) offer promising results, less postoperative discomfort lower complication rates. However, further large-scale studies are needed refine surgical techniques, assess long-term outcomes, optimize individualized strategies OSA.

Language: Английский

Paediatric dental trauma: insights from epidemiological studies and management recommendations DOI Creative Commons
Alessandra Laforgia, Angelo Michele Inchingolo, Francesco Inchingolo

et al.

BMC Oral Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 2, 2025

Abstract Dental trauma is common in all age groups, although, epidemiologically, it more children with studies that indicate 15% of preschoolers and 20–25% school-age experience it. These injuries, which frequently call for immediate attention, can affect the hard tissues supporting components teeth, and, because dental damage deciduous teeth occurs affects speech, nutrition, oral development, particularly worrying. After searching three databases, Scopus, Web Science (WoS), PubMed, removing duplicates, 3,630 articles were screened, 12 publications included qualitative analysis. Due to their busy lifestyles, are susceptible certain areas lower socioeconomic incidence higher. From little fractures enamel serious dislocations avulsions, injuries vary must be treated promptly order avoid consequences prevent long-term issues. Furthermore, a conservative treatment strategy recommended preserve tooth vitality extractions. Reducing occurrence requires implementation preventive measures including mouthguard use educational campaigns. In summary, this review emphasizes importance early diagnosis, management, care, by synthesizing existing knowledge on prevalence, types, complications, prevention teeth. Finally, it’s important underscore need continued research refine approaches.

Language: Английский

Citations

1
The Role of Platelet Concentrates and Growth Factors in Facial Rejuvenation: A Systematic Review with Case Series DOI Creative Commons
Giuseppina Malcangi, Angelo Michele Inchingolo, Alessio Danilo Inchingolo

et al.

Medicina, Journal Year: 2025, Volume and Issue: 61(1), P. 84 - 84

Published: Jan. 7, 2025

Background and objectives: Due to the regeneration potential of growth factors (GFs) platelet concentrates (PCs), facial rejuvenation has been a major area attention in esthetic medicine. The effectiveness safety PCs GFs promoting face are examined this systematic review, which is complemented by case series. essential for collagen production dermal matrix remodeling, while PCs, like Platelet-Rich Plasma (PRP), abundant bioactive chemicals that promote tissue healing cellular regeneration. Materials Methods: A comprehensive literature search was performed on PubMed, Web Science, Scopus, focusing human clinical trials published between February 2019 2024 related PRP esthetics. Results: Thirteen studies met inclusion criteria were analyzed. Conclusions: review summarizes most recent data patient outcomes, treatment regimens, possible hazards. series goes with it shows real-world examples how improve skin elasticity, texture, general appearance little negative side effects. These results highlight use as minimally invasive procedures.

Language: Английский

Citations

1
Stem Cells: Present Understanding and Prospects for Regenerative Dentistry DOI Creative Commons
Angelo Michele Inchingolo, Alessio Danilo Inchingolo, Paola Nardelli

et al.

Journal of Functional Biomaterials, Journal Year: 2024, Volume and Issue: 15(10), P. 308 - 308

Published: Oct. 15, 2024

Regenerative medicine in dentistry focuses on repairing damaged oral tissues using advanced tools like stem cells, biomaterials, and tissue engineering (TE). Mesenchymal cells (MSCs) from dental sources, such as pulp periodontal ligament, show significant potential for regeneration due to their proliferative differentiative abilities. This systematic review, following PRISMA guidelines, evaluated fifteen studies identified effective strategies improving dental, periodontal, bone through scaffolds, secretomes, bioengineering methods. Key advancements include the use of (DPSCs) ligament (PDLSCs) boost cell viability manage inflammation. Additionally, pharmacological agents matrine surface modifications biomaterials improve adhesion promote osteogenic differentiation. By integrating these approaches, regenerative TE can optimize therapies enhance patient outcomes. review highlights challenges this field, providing a critical assessment current research future directions.

Language: Английский

Citations

4
The Therapeutic Effects of Curcumin on Oral Disease: A Systematic Review DOI Creative Commons

Novi Indriyani,

Nanan Nur’aeny

Clinical Pharmacology Advances and Applications, Journal Year: 2025, Volume and Issue: Volume 17, P. 13 - 24

Published: Feb. 1, 2025

Curcumin is an extract from herbal plants that has been implicated in the treatment of any disease, including oral disease. There are various types curcumin formulation as option therapy. The aim this review to describe mechanism reducing severity, pain score, and lesion size therapeutic effects. This systematic used Preferred Reporting Items for Systematic Review Meta Analysis (PRISMA) guidelines. Databases articles include PubMed, Science Direct, Scopus with inclusion criteria published 2014 2024, full text, English, randomized controlled trial (RCT). present study included 21 RCTs a total 1244 individuals. In study, was most commonly submucous fibrosis, 9 studies demonstrating anti-inflammatory properties inhibits collagenase. All demonstrate produces significant results management remain showed antioxidant, inhibit collagenase, antifungal, wound healing leukoplakia, recurrent aphthous stomatitis (RAS), lichen planus (OLP), denture stomatitis. anti inflammatory, severity lesion, score effects patients disease OSMF, mucositis, RAS, OLP,

Language: Английский

Citations

0
Xanthine Derivative KMUP‐3 Alleviates Periodontal Bone Resorption by Inhibiting Osteoclastogenesis and Macrophage Pyroptosis DOI Creative Commons
Shang‐En Huang, Kai‐Fang Hu, Mengxuan Lin

et al.

Journal of Periodontal Research, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 26, 2025

ABSTRACT Aim This study investigated the function effects of KMUP‐3, a self‐developed synthetic xanthine‐based derivative, in suppressing Porphyromonas gingivalis ( Pg ‐LPS)‐aggravated osteoclastogenesis and pyroptosis as potential treatment for periodontitis. Methods In vitro, ‐LPS KMUP‐3 on osteoclast formation macrophage were using receptor activator nuclear factor‐κB ligand (RANKL)‐primed RAW264.7 macrophages. vivo, therapeutic evaluated model experimental periodontitis induced by gingival ligature placement. Results We reveal that suppressed osteoclastogenesis, inducible nitric oxide synthase activation, reduced production enhanced RANKL‐primed cells while also decreasing TLR4/NF‐κB p65 pathway activation decreased pro‐inflammatory cytokine production; moreover, promoted NLRP3 exacerbated induction abolished KMUP‐3. Finally, ameliorated alveolar bone loss IL‐1β levels crevicular fluid rat model. Conclusions Our demonstrated attenuates ‐LPS‐enhanced pyroptosis. Notably, alleviates rats thus suggests its certain role safeguarding against periodontal resorption.

Language: Английский

Citations

0
Sublethal Curcumin Exposure Induces Global Gene Expression and Biofilm-Related Phenotypic Changes in Vibrio parahaemolyticus DOI

Lili Huang,

Miaomiao Zhang, Xi Luo

et al.

Current Microbiology, Journal Year: 2025, Volume and Issue: 82(5)

Published: March 26, 2025

Language: Английский

Citations

0
The Effectiveness of Curcumin in Treating Oral Mucositis Related to Radiation and Chemotherapy: A Systematic Review DOI Creative Commons
Gianna Dipalma, Angelo Michele Inchingolo, G Latini

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(10), P. 1160 - 1160

Published: Sept. 25, 2024

Chemotherapy (CT) and radiation therapy (RT), while effective against cancer, often cause severe side effects, such as oral mucositis other diseases. Oral mucositis, characterized by inflammation ulceration of the mucosa, is one most painful effects that can reduce quality life limit cancer treatment. Curcumin, a polyphenol from Curcuma longa, has garnered attention for its anti-inflammatory, antioxidant, anti-carcinogenic properties, which protect mucosa reducing oxidative stress modulating inflammation. This study reviews therapeutic potential curcumin in preventing managing caused CT RT. Clinical trials show curcumin’s effectiveness incidence severity mucositis. Although supplementation appears to be promising cost-effective approach mitigating complications patients, further clinical are needed confirm efficacy optimize dosing strategies.

Language: Английский

Citations

3
New Perspectives about Relevant Natural Compounds for Current Dentistry Research DOI Creative Commons
Ştefania Dinu,

Stefania-Irina Dumitrel,

Roxana Buzatu

et al.

Life, Journal Year: 2024, Volume and Issue: 14(8), P. 951 - 951

Published: July 29, 2024

Natural compounds have been used since the earliest civilizations and remain, to this day, a safer alternative for treating various dental problems. These present antimicrobial, anti-inflammatory, antioxidant, analgesic, antimutagenic effects, making them useful in prophylactic curative treatment of oral diseases such as infections, gingivitis, periodontitis, even cancer. Due high incidence unpleasant adverse reactions synthetic compounds, natural products tend gradually replace conventional treatment, they can be just potent cause fewer, milder effects. Researchers use several methods measure effectiveness safety profile these employing standard techniques also contributes progress across all medical disciplines.

Language: Английский

Citations

1
Orthopedic Devices for Skeletal Class III Malocclusion Treatment in Growing Patients: A Comparative Effectiveness Systematic Review DOI Open Access
Angelo Michele Inchingolo, Alessio Danilo Inchingolo, Irma Trilli

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(23), P. 7141 - 7141

Published: Nov. 25, 2024

Background/Objectives: Skeletal Class III malocclusion (Cl III) presents a significant orthodontic challenge, particularly in growing patients, requiring interceptive treatment to achieve effective functional and aesthetic correction. This review aims compare various orthopedic devices therapeutic protocols used Cl correction, identifying the most options an context. Methods: We searched PubMed, Scopus, Web of Science databases for studies published between 1 January 2003, 19 July 2023. Inclusion criteria included English language, human studies, open access, addressing correction with devices. Results: Exclusions vitro, animal, off-topic reviews, meta-analyses, articles languages other than English. After removing duplicates, 30 were selected from total 1193 results. Conclusions: The application patients can lead rapid improvement malocclusion, although each device has specific effects on surrounding skeletal structure.

Language: Английский

Citations

0
Surgical Management of Pediatric Obstructive Sleep Apnea: Efficacy, Outcomes, and Alternatives—A Systematic Review DOI Creative Commons
Gianna Dipalma, Angelo Michele Inchingolo, Irene Palumbo

et al.

Life, Journal Year: 2024, Volume and Issue: 14(12), P. 1652 - 1652

Published: Dec. 12, 2024

Aim: Obstructive sleep apnea (OSA) is the most prevalent sleep-related breathing disorder. OSA affects approximately 2 million Italians, although only 3% receive a diagnosis and correct treatment. This review aims to provide an overview guide clinical decision making, ensuring that patients appropriate treatment for their specific condition. Material Methods: systematic was conducted according Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA) guidelines registered at PROSPERO under ID CRD42024593760. A search on PubMed, Scopus, Web of Science performed find papers matched topic, using following Boolean keywords: (“obstructive apnea” OR “OSA” “sleep apnea, obstructive”) AND (“surgery” “surgical” “surgical techniques” treatment” “operative” procedures”) (“treatment” “therapy” “management”). Result: The electronic database found 20337 publications. After screening eligibility phase, 15 were chosen qualitative analysis. Conclusions: Adenotonsillectomy (AT) significantly improves secondary outcomes like behavioral issues quality life, compared watchful waiting with supportive care (WWSC). Alternative approaches such as tonsillotomy adenopharyngoplasty (APP) offer promising results, less postoperative discomfort lower complication rates. However, further large-scale studies are needed refine surgical techniques, assess long-term outcomes, optimize individualized strategies OSA.

Language: Английский

Citations

0