Chlorogenic Acid Enhances Beta‐Lapachone‐Induced Cell Death by Suppressing Autophagy in NQO1‐Positive Cancer Cells DOI Creative Commons
Sahib Zada, Md Entaz Bahar, Wanil Kim

et al.

Cell Biology International, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

ABSTRACT Resistance to apoptosis‐inducing drugs frequently occurs in cancer cells, limiting their usefulness ongoing treatment. Despite efforts overcome drug resistance, a definitive solution remains elusive. However, autophagy inhibition has been shown enhance the effectiveness of some anticancer and is possible strategy for overcoming resistance. In this study, we demonstrate that chlorogenic acid (CGA), natural antioxidant, significantly enhances beta‐lapachone (β‐Lap)‐induced cell death cells. The augmented apoptosis induced by CGA associated with activation protein kinase A (PKA) β‐Lap–treated independent antioxidant properties CGA. As result, PKA cells co‐treated β‐Lap effectively inhibits autophagy. Notably, leads phosphorylation microtubule‐associated 1 A/1B‐light chain 3 (LC3) at serine 12 residue, causing suppression irrespective mTORC activity. Importantly, NQO1‐overexpressing breast or lung cancers closely linked inhibition. These findings suggest combining might be novel therapy, particularly resistance caused induction

Language: Английский

Chlorogenic Acid Enhances Beta‐Lapachone‐Induced Cell Death by Suppressing Autophagy in NQO1‐Positive Cancer Cells DOI Creative Commons
Sahib Zada, Md Entaz Bahar, Wanil Kim

et al.

Cell Biology International, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

ABSTRACT Resistance to apoptosis‐inducing drugs frequently occurs in cancer cells, limiting their usefulness ongoing treatment. Despite efforts overcome drug resistance, a definitive solution remains elusive. However, autophagy inhibition has been shown enhance the effectiveness of some anticancer and is possible strategy for overcoming resistance. In this study, we demonstrate that chlorogenic acid (CGA), natural antioxidant, significantly enhances beta‐lapachone (β‐Lap)‐induced cell death cells. The augmented apoptosis induced by CGA associated with activation protein kinase A (PKA) β‐Lap–treated independent antioxidant properties CGA. As result, PKA cells co‐treated β‐Lap effectively inhibits autophagy. Notably, leads phosphorylation microtubule‐associated 1 A/1B‐light chain 3 (LC3) at serine 12 residue, causing suppression irrespective mTORC activity. Importantly, NQO1‐overexpressing breast or lung cancers closely linked inhibition. These findings suggest combining might be novel therapy, particularly resistance caused induction

Language: Английский

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