Evaluation of anti-inflammatory activity of Tinospora Cordifolia extract through in-vitro and in-vivo methods DOI Creative Commons

Anjum Pervaiz,

Faha Yousaf, Rashid Iqbal

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 12, 2024

Abstract Rheumatoid arthritis (RA) is a systematic autoimmune disease that causes joint inflammation, pain and stiffness, leading to loss of function the joint. However, pharmacological treatments are usually accompanied by undesired adverse side effects, therefore, there has been relatively increased concern in other forms treatment. In this research, possible treatment effects Tinospora cordifolia examined given plant possesses anti-inflammatory immunomodulatory properties. Thus, in vivo vitro approaches were employed conducting research. In study entailed use extract on an animal model RA determine its therapeutic efficacy relation swelling, inflammation. Some animals received for pre – determined period clinical signs like paw swelling score assessed. The changes degree tissue injury inflammation at cellular level also assessed using histopathological examination. studies analyzed scientific performance immune cells secretion inflammatory cytokines. PBMCs prepared cultured with levels TNF-α IL-1β, IL-6 estimated. Cell viability regulation cytokine gene expression measured enzyme-linked immunosorbent assay (ELISA) quantitative real-time PCR, respectively. findings showed tested compounds reduced model, as well suppressed generation pro-inflammatory cytokines experiments. It further evidence may have activity could be used complementary or even alternative conventional medicines. more required before pinpointing bioactive accountable depicted herein.

Language: Английский

Exploring Synergistic Benefits and Clinical Efficacy of Turmeric in Management of Inflammatory and Chronic Diseases: A Traditional Chinese Medicine Based Review DOI Creative Commons
Divya Jain, Kuldeep Singh,

Paras Gupta

et al.

Pharmacological Research - Modern Chinese Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 100572 - 100572

Published: Jan. 1, 2025

Language: Английский

Citations

0
Bacopaside I, acting as an aquaporin 1 inhibitor, ameliorates rheumatoid arthritis via suppressing aquaporin 1-mediated autophagy DOI
Yan Huang,

Meng‐yuan Zhou,

Lingling Li

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: 138, P. 156444 - 156444

Published: Jan. 29, 2025

Language: Английский

Citations

0
Functional foods for bone and joint health: building a solid foundation DOI
Zahra Emam‐Djomeh, Homa Behmadi, Elham Azarpazhooh

et al.

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 233 - 256

Published: Jan. 1, 2025

Language: Английский

Citations

0
A COMPLETE SOJOURN ON NANOTECHNOLOGICAL ADVANCEMENTS AND NANOCARRIERS APPLICATIONS IN ARTHRITIS MANAGEMENT DOI
Ashwani Kumar, Rashmi Maurya, Preeti Patel

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106705 - 106705

Published: Feb. 1, 2025

Language: Английский

Citations

0
Antioxidant and Anti-Inflammatory Activities of Methanol Extract of Senna septemtrionalis (Viv.) H.S. Irwin & Barneby Through Nrf2/HO-1-Mediated Inhibition of NF-κB Signaling in LPS-Stimulated Mouse Microglial Cells DOI Open Access

Jae Sung Lim,

Xiangying Li, Da Young Lee

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 1932 - 1932

Published: Feb. 24, 2025

Botanical extracts are recognized in traditional medicine for their therapeutic potential and safety standards. viable sustainable alternatives to synthetic drugs, being essential drug discovery various diseases. Senna septemtrionalis (Viv.) H.S. Irwin & Barneby is a medical plant traditionally used treat inflammation. However, its antioxidant anti-inflammatory properties the molecular pathways activated microglial cells require further investigation. Therefore, this study examines of methanol (SMEs) lipopolysaccharide (LPS)-stimulated mouse cells. SMEs significantly inhibit LPS-induced nitric oxide (NO) proinflammatory cytokine production, which mediated through dephosphorylation mitogen-activated protein kinases inhibition nuclear factor kappa B (NF-κB) translocation into nucleus. Additionally, SME treatment upregulated expression erythroid 2-related 2 (Nrf2) heme oxygenase (HO)-1, reducing oxidative stress, indicated by decrease reactive oxygen species restoration total glutathione content LPS-stimulated BV2 The inhibitory effects on inflammatory mediator production NF-κB were reversed Sn-protoporphyrin, specific HO-1 inhibitor. These findings demonstrate that protects activating Nrf2/HO-1 pathway inhibiting translocation.

Language: Английский

Citations

0
Phytochemical studies of Gerbera jamesonii and evaluation of anti-inflammatory potential in formaldehyde-induced arthritis in rats DOI

Malik Saad Ullah,

Adnan Amjad, Zunera Chauhdary

et al.

Inflammopharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: April 3, 2025

Language: Английский

Citations

0
Evaluation of anti-inflammatory activity of Tinospora Cordifolia extract through in-vitro and in-vivo methods DOI Creative Commons

Anjum Pervaiz,

Faha Yousaf, Rashid Iqbal

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 12, 2024

Abstract Rheumatoid arthritis (RA) is a systematic autoimmune disease that causes joint inflammation, pain and stiffness, leading to loss of function the joint. However, pharmacological treatments are usually accompanied by undesired adverse side effects, therefore, there has been relatively increased concern in other forms treatment. In this research, possible treatment effects Tinospora cordifolia examined given plant possesses anti-inflammatory immunomodulatory properties. Thus, in vivo vitro approaches were employed conducting research. In study entailed use extract on an animal model RA determine its therapeutic efficacy relation swelling, inflammation. Some animals received for pre – determined period clinical signs like paw swelling score assessed. The changes degree tissue injury inflammation at cellular level also assessed using histopathological examination. studies analyzed scientific performance immune cells secretion inflammatory cytokines. PBMCs prepared cultured with levels TNF-α IL-1β, IL-6 estimated. Cell viability regulation cytokine gene expression measured enzyme-linked immunosorbent assay (ELISA) quantitative real-time PCR, respectively. findings showed tested compounds reduced model, as well suppressed generation pro-inflammatory cytokines experiments. It further evidence may have activity could be used complementary or even alternative conventional medicines. more required before pinpointing bioactive accountable depicted herein.

Language: Английский

Citations

0