Potential Strategies for Overcoming Drug Resistance Pathways Using Propolis and Its Polyphenolic/Flavonoid Compounds in Combination with Chemotherapy and Radiotherapy

Nutrients, Journal Year: 2024, Volume and Issue: 16(21), P. 3741 - 3741

Published: Oct. 31, 2024

Conventional cancer treatments include surgical resection, chemotherapy, hyperthermia, immunotherapy, hormone therapy, and locally targeted therapies such as radiation therapy. Standard often require the use of multiple agents, which can activate nuclear factor kappa B (NF-κB) in tumor cells, leading to reduced cell death increased drug resistance. Moreover, agents also contributes added toxicity, resulting poor treatment outcomes. Cancer cells gradually develop resistance almost all chemotherapeutics through various mechanisms, efflux, alterations metabolism transport, changes signal transduction pathways, enhanced DNA repair capacity, evasion apoptosis, mutations, reactivation targets, interaction with microenvironment, cell-stroma interactions, epithelial–mesenchymal transition (EMT)-mediated chemoresistance, epigenetic modifications, metabolic alterations, effect stem (CSCs). Developing new strategies improve chemotherapy sensitivity while minimizing side effects is essential for achieving better therapeutic outcomes enhancing patients’ quality life. One promising approach involves combining conventional propolis its flavonoids. These natural compounds may enhance response reducing toxicity. Propolis components sensitize chemotherapeutic likely by inhibiting NF-κB activation, reprogramming tumor-associated macrophages (TAMs; an M2-like phenotype), thereby release matrix metalloproteinase (MMP)-9, cytokines, chemokines, vascular endothelial growth (VEGF). By TAMs, overcome EMT-mediated disrupt crosstalk between CSCs, inhibit maintenance stemness, reverse acquired immunosuppression, thus promoting antitumor mediated cytotoxic T-cells. This review highlights potential flavonoids modulate responsiveness modalities. The evidence suggests that novel incorporating could be developed positive cytotoxicity peripheral blood leukocytes, liver, kidney cells. Therefore, polyphenolic/flavonoid hold combination clinical types cancers.

Language: Английский

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An overview of potential of natural compounds to regulate epigenetic modifications in colorectal cancer: a recent update

Epigenetics, Journal Year: 2025, Volume and Issue: 20(1)

Published: April 16, 2025

Colorectal cancer (CRC) remains an alarming global health concern despite advancements in treatment modalities over recent decades. Among the various factors contributing to CRC, this review emphasizes critical role of epigenetic mechanisms its pathogenesis and progression. This also describes potential natural compounds altering landscape, focused mainly on DNA methylation, histone modification, non-coding RNAs. Publications from previous five years were searched retrieved using well-known search engines databases like PubMed, Google Scholar, ScienceDirect. Keywords CRC/colorectal cancer, CAC/Colitis associated inflammasomes, modulation, genistein, curcumin, quercetin, resveratrol, anthocyanins, sulforaphane, epigallocatechin-3-gallate used combinations during search. These predominantly affect pathways such as Wnt/β-catenin, NF-κB, PI3K/AKT suppress CRC cell proliferation oxidative stress enhance anti-inflammation apoptosis. However, their clinical use is restricted due low bioavailability. multiple methods exist overcome challenges this, including but not limited structural modifications, nanoparticle encapsulations, bio-enhancers, novel advanced delivery systems. improve supportive therapies that target progression epigenetically with fewer side effects. Current research focuses enhancing targeting control while minimizing effects, emphasizing improved specificity, bioavailability, efficacy standalone or synergistic therapies.

Language: Английский

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Synergistic Combination of Quercetin and Mafosfamide in Treatment of Bladder Cancer Cells

Molecules, Journal Year: 2024, Volume and Issue: 29(21), P. 5176 - 5176

Published: Oct. 31, 2024

Bladder cancer, which has a rising incidence, is the 10th most common cancer. The transitional cell carcinoma histotype aggressive and often current therapies are ineffective. We investigated anti-proliferative effect of quercetin, natural flavonoid, in combination with alkylating agent mafosfamide (MFA) on two human bladder cancer lines, namely RT112 J82, representing progression from low-grade to high-grade tumors, respectively. In both types, combined treatment led synergic reduction viability confirmed by index less than one, though different biological responses were noted. J82 cells, MFA alone and, lesser extent, quercetin caused cycle arrest G2/M phase, but only triggered apoptotic death. contrast, induced autophagy, evidenced autophagosome formation increase LC-3 lipidation. Interestingly, synergistic was observed when cells pre-treated for 24 h before adding not reverse order. This suggests that may help overcome resistance apoptosis. Although further studies needed, investigating effects could elucidate mechanisms drug treatment.

Language: Английский

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Development of resistance to anticancer medications: Challenges and clinical implications

Side effects of drugs annual, Journal Year: 2024, Volume and Issue: unknown, P. 517 - 530

Published: Jan. 1, 2024

Language: Английский

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