Approaches to Identifying Markers of Effect of Environment and Nutrition in Preschoolers DOI
Tatyana V. Mazhaeva, Vladimir B. Gurvich, Marina P. Sutunkova

et al.

ЗДОРОВЬЕ НАСЕЛЕНИЯ И СРЕДА ОБИТАНИЯ - ЗНиСО / PUBLIC HEALTH AND LIFE ENVIRONMENT, Journal Year: 2024, Volume and Issue: unknown, P. 73 - 80

Published: Oct. 1, 2024

Background: Identification of the markers effect environment and nutrition on human body, given their interplay, remains relevant for health risk assessment. Objective: To identify children’s effects environmental exposures with account mutual influences. Materials methods: The study involved 197 preschool children living in two towns Sverdlovsk Region different levels pollution. In January 2022 to June 2024, we tested mass concentrations 19 metals, cytogenetic parameters buccal epithelium, interleukins (IL-1, IL-4), glutathione-S-transferase, 60 organic acids urine subjects. We also evaluated menu off-school nutrition, anthropometric parameters, morbidity based outpatient cards, status using a questionnaire-based survey. Microsoft Excel IBM SPSS were used statistical data analysis. Results: established that territory high airborne risks, exposure seven chemicals exceeded reference values, especially those aluminum manganese by 3.9 2.5 times, respectively. Cytogenetic damage epithelial cells, higher values allergic reactions (IL 4), glutathione-S-transfer acids, detoxification more frequent this group (p < 0.001). noted diet was deficient vitamins B1 C, calcium, and, judging essential amino B9 B12. exposed differed from controls arsenic, mercury, copper; there larger proportion (85 %) cells micronuclei atypical nuclei, inflammatory cytokines 1), energy protein deficiencies, excess sugars diet, metabolism disorders among them. Conclusions: identified non-adaptive metabolotypes nutritional phenotypes will allow differentiated approach developing diets.

Language: Английский

Xenotopic synthetic biology: Prospective tools for delaying aging and age-related diseases DOI Creative Commons
Andrey A. Parkhitko, Valentin Cracan

Science Advances, Journal Year: 2025, Volume and Issue: 11(13)

Published: March 28, 2025

Metabolic dysregulation represents one of the major driving forces in aging. Although multiple genetic and pharmacological manipulations are known to extend longevity model organisms, aging is a complex trait, targeting one’s own genes may be insufficient prevent age-dependent deterioration. An alternative strategy could use enzymes from other species reverse age-associated metabolic changes. In this review, we discuss set lower organisms that have been shown affect various parameters linked age-related processes. These include modulators steady-state levels amino acids (METase, ASNase, ADI), NADPH/NADP + and/or reduced form coenzyme Q (CoQH 2 )/CoQ redox potentials (NDI1, AOX, Lb NOX, TPNOX, Ec STH, RquA, LOXCAT, Grubraw, ScURA), GSH (StGshF), mitochondrial membrane potential (mtON mito-dR), or reactive oxygen (DAAO KillerRed-SOD1). We propose leveraging non-mammalian an untapped resource can used delay diseases.

Language: Английский

Citations

0
Polygonatum sibiricum Polysaccharides Alleviate LPS-Induced Liver Injury in Chicks by Suppressing Inflammation and Oxidative Stress Through the PPAR Signaling Pathway DOI Creative Commons
Yang Li, Jianping Li, Xiaowang Liu

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(4), P. 418 - 418

Published: March 31, 2025

Polygonatum sibiricum polysaccharides (PSPs), plant-derived widely used in the pharmaceutical field, exhibit various biological activities, including anti-inflammatory and antioxidant effects. However, research on their application chicks remains limited. Therefore, aim of this study is to investigate protective mechanism PSP against liver injury using an LPS-induced inflammatory model. A total 200 one-day-old Hy-Line Brown laying were randomly assigned five groups (40 each): a control group (CON) fed basal diet, LPS group, three receiving low (250 mg/L), medium (500 high (1000 mg/L) doses (PSP250_LPS, PSP500_LPS, PSP1000_LPS, respectively). The experiment lasted 21 days. During period, intraperitoneally injected with 1500 μg/kg days 14, 16, 18, 20, while CON received normal saline. On day 21, organs collected for analysis. results indicated that treatment significantly reduced kidney indices elevated by (p < 0.05) without affecting spleen, thymus, or bursa Fabricius > 0.05). Histological analysis revealed alleviated ballooning degeneration cell swelling hepatocytes. Furthermore, decreased levels ALT AST mitigated increases pro-inflammatory cytokines IL-1β, IL-6, TNF-α enhancing level cytokine IL-10 Transcriptome sequencing samples altered expression 10 genes peroxisome proliferator-activated receptor (PPAR) signaling pathway, which regulated intervention. qPCR validation supported these findings. biochemical analyses tissue showed oxidative stress SOD, MDA, NADPH, ROS, H2O2. In conclusion, may alleviate modulating PPAR pathway. These findings provide valuable insights promoting healthy chick rearing ensuring safe supply poultry products.

Language: Английский

Citations

0
Approaches to Identifying Markers of Effect of Environment and Nutrition in Preschoolers DOI
Tatyana V. Mazhaeva, Vladimir B. Gurvich, Marina P. Sutunkova

et al.

ЗДОРОВЬЕ НАСЕЛЕНИЯ И СРЕДА ОБИТАНИЯ - ЗНиСО / PUBLIC HEALTH AND LIFE ENVIRONMENT, Journal Year: 2024, Volume and Issue: unknown, P. 73 - 80

Published: Oct. 1, 2024

Background: Identification of the markers effect environment and nutrition on human body, given their interplay, remains relevant for health risk assessment. Objective: To identify children’s effects environmental exposures with account mutual influences. Materials methods: The study involved 197 preschool children living in two towns Sverdlovsk Region different levels pollution. In January 2022 to June 2024, we tested mass concentrations 19 metals, cytogenetic parameters buccal epithelium, interleukins (IL-1, IL-4), glutathione-S-transferase, 60 organic acids urine subjects. We also evaluated menu off-school nutrition, anthropometric parameters, morbidity based outpatient cards, status using a questionnaire-based survey. Microsoft Excel IBM SPSS were used statistical data analysis. Results: established that territory high airborne risks, exposure seven chemicals exceeded reference values, especially those aluminum manganese by 3.9 2.5 times, respectively. Cytogenetic damage epithelial cells, higher values allergic reactions (IL 4), glutathione-S-transfer acids, detoxification more frequent this group (p < 0.001). noted diet was deficient vitamins B1 C, calcium, and, judging essential amino B9 B12. exposed differed from controls arsenic, mercury, copper; there larger proportion (85 %) cells micronuclei atypical nuclei, inflammatory cytokines 1), energy protein deficiencies, excess sugars diet, metabolism disorders among them. Conclusions: identified non-adaptive metabolotypes nutritional phenotypes will allow differentiated approach developing diets.

Language: Английский

Citations

0