Causal and mediating effects of lipid and facial aging: association study integrating GWAS, eQTL, mQTL, and pQTL data DOI Creative Commons

Mingjian Zhao,

Zhichao He, Lukuan Liu

et al.

Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)

Published: Oct. 21, 2024

Increasing evidence suggests a potential causal association between lipid levels and facial aging. The aim of this study was to investigate the relationship specific lipids aging via Mendelian randomization methods. Additionally, aimed identify mediators explore relevant genes drug targets. In study, genome-wide data on plasma from 7,174 Finnish individuals in UK Biobank were used. Two-sample applied assess effects Sensitivity pleiotropy analyses conducted ensure robustness reliability results. Multivariate account for impact confounding factors. Furthermore, summary-data-based used genes, which validated through multiomics data. Finally, drug‒gene interactions explored molecular docking techniques. analysis revealed According multivariate results, smoking found mediate association, these remained significantly associated with aging, even after accounting environmental confounders. Using randomization, CYP21A2, CCND1, PSMA4, MED1 identified as gene targets, further pQTL mQTL protein bind spontaneously astragalin, fenofibrate, ginsenoside. results revealing key targets that still controlling certain drugs may indicate pathways therapeutic interventions related

Language: Английский

Characterization and Anti-Aging Potency of Phenolic Compounds in Xianhu Tea Extracts DOI Creative Commons
Guangwen Zhang, Wenwen Jiang,

Qing Hu

et al.

Foods, Journal Year: 2025, Volume and Issue: 14(5), P. 737 - 737

Published: Feb. 21, 2025

The health benefits of tea are primarily attributed to its chemical composition, particularly phenolic compounds. As a renowned from Guangdong, China, Xianhu (XHT) has not been thoroughly studied in terms composition or health-promoting properties. This study characterized the compounds water extract using liquid chromatography-tandem mass spectrometry (LC-MS/MS) and evaluated antioxidant activity vitro. Furthermore, effects XHT extracts on reactive oxygen species (ROS), malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), lipofuscin levels, lifespan Caenorhabditis elegans were assessed, alongside their modulation aging-related genes. Compared with Xinyang Maojian (XYMJ) Yingde black (YDBT), exhibited significantly higher polyphenol content, 23 identified as characteristic markers. demonstrated superior 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical-scavenging 2,2'-azinobis-(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) inhibition capacities, greatest reductions ROS, MDA, highest upregulation SOD CAT activities. was 23.50% 21.07% longer than nematodes control group. Moreover, modulated 13 genes, which strongly correlated research results above indicators all obtained without affecting normal feeding reproductive capabilities C. elegans. These findings suggest that these phenolics key bioactive components responsible for anti-aging XHT.

Language: Английский

Citations

0
Astragalin actives autophagy and inhibits apoptosis of astrocytes in AD mice via down-regulating Fas/Fasl-VDAC1 pathway DOI
Shuhan Wang, Yaqi Yang,

Jiahong Lin

et al.

Free Radical Biology and Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Development of anti-bacterial bio-transfer double sheet layer of polyvinyl alcohol/carboxymethyl cellulose films infused with Astragalus tribuloides leaf extract for beef burgers preservation DOI
Mohamed Abdin,

Salwa Arafa,

A. E. El-Beltagy

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 284, P. 138196 - 138196

Published: Nov. 29, 2024

Language: Английский

Citations

3
Identification of Cellular Isoschaftoside-Mediated Anti-Senescence Mechanism in RAC2 and LINC00294 DOI Creative Commons

Yun Haeng Lee,

Byeong Hyeon So,

Kyeong Seon Lee

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(17), P. 4182 - 4182

Published: Sept. 4, 2024

As cellular senescence, reactive oxygen species (ROS) accumulate excessively, causing damage. Flavonoids derived from natural products are known for their antioxidant effects and ability to delay senescence. Previous studies have attempted mitigate senescence using flavonoids sources. However, the detailed mechanisms regulatory targets of some exhibiting not been fully elucidated. Therefore, we screened a library properties. Isoschaftoside, glycosidic flavonoid, significantly reduced ROS levels in senescent cells. It was found that mitochondrial function restored, dependence on glycolysis cells treated with isoschaftoside. Additionally, identified isoschaftoside suppresses by reducing expression

Language: Английский

Citations

1
Causal and mediating effects of lipid and facial aging: association study integrating GWAS, eQTL, mQTL, and pQTL data DOI Creative Commons

Mingjian Zhao,

Zhichao He, Lukuan Liu

et al.

Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)

Published: Oct. 21, 2024

Increasing evidence suggests a potential causal association between lipid levels and facial aging. The aim of this study was to investigate the relationship specific lipids aging via Mendelian randomization methods. Additionally, aimed identify mediators explore relevant genes drug targets. In study, genome-wide data on plasma from 7,174 Finnish individuals in UK Biobank were used. Two-sample applied assess effects Sensitivity pleiotropy analyses conducted ensure robustness reliability results. Multivariate account for impact confounding factors. Furthermore, summary-data-based used genes, which validated through multiomics data. Finally, drug‒gene interactions explored molecular docking techniques. analysis revealed According multivariate results, smoking found mediate association, these remained significantly associated with aging, even after accounting environmental confounders. Using randomization, CYP21A2, CCND1, PSMA4, MED1 identified as gene targets, further pQTL mQTL protein bind spontaneously astragalin, fenofibrate, ginsenoside. results revealing key targets that still controlling certain drugs may indicate pathways therapeutic interventions related

Language: Английский

Citations

0