Berberine Extends Lifespan in C. elegans Through Multi-Target Synergistic Antioxidant Effects DOI Creative Commons

Yingshuo Bei,

Ting Wang, Shuwen Guan

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(4), P. 450 - 450

Published: April 9, 2025

Aging is a process of gradual functional decline in complex physiological systems and closely related to the occurrence various diseases. Berberine, bioactive alkaloid derived from Coptis chinensis (Huanglian), has emerged as promising candidate for anti-aging interventions. This study comprehensively investigated lifespan-extending effects molecular mechanisms berberine C. elegans through integrated approaches including lifespan assays, locomotor activity analysis, oxidative stress challenges, transcriptomic profiling. Furthermore, genetic models mutant transgenic worms were employed delineate their interactions with insulin/IGF-1 signaling (IIS) pathway. Our results demonstrate that extended mean wild-type by 27%. By activating transcription factors such DAF-16/FOXO, HSF-1, SKN-1/NRF2, upregulated antioxidant enzyme expression, reduced lipofuscin accumulation, improved resistance. Transcriptomic analysis revealed significant changes lipid metabolism-related genes, particularly pathways involving fatty acid synthesis, degradation, sphingolipid metabolism. These findings establish exerts multi-target coordinated activation stress-responsive metabolic optimization, providing mechanistic insights developing natural product-based geroprotective strategies.

Language: Английский

Berberine Extends Lifespan in C. elegans Through Multi-Target Synergistic Antioxidant Effects DOI Creative Commons

Yingshuo Bei,

Ting Wang, Shuwen Guan

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(4), P. 450 - 450

Published: April 9, 2025

Aging is a process of gradual functional decline in complex physiological systems and closely related to the occurrence various diseases. Berberine, bioactive alkaloid derived from Coptis chinensis (Huanglian), has emerged as promising candidate for anti-aging interventions. This study comprehensively investigated lifespan-extending effects molecular mechanisms berberine C. elegans through integrated approaches including lifespan assays, locomotor activity analysis, oxidative stress challenges, transcriptomic profiling. Furthermore, genetic models mutant transgenic worms were employed delineate their interactions with insulin/IGF-1 signaling (IIS) pathway. Our results demonstrate that extended mean wild-type by 27%. By activating transcription factors such DAF-16/FOXO, HSF-1, SKN-1/NRF2, upregulated antioxidant enzyme expression, reduced lipofuscin accumulation, improved resistance. Transcriptomic analysis revealed significant changes lipid metabolism-related genes, particularly pathways involving fatty acid synthesis, degradation, sphingolipid metabolism. These findings establish exerts multi-target coordinated activation stress-responsive metabolic optimization, providing mechanistic insights developing natural product-based geroprotective strategies.

Language: Английский

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