Redox Homeostasis, Gut Microbiota, and Epigenetics in Neurodegenerative Diseases: A Systematic Review

Antioxidants, Journal Year: 2024, Volume and Issue: 13(9), P. 1062 - 1062

Published: Aug. 30, 2024

Neurodegenerative diseases encompass a spectrum of disorders marked by the progressive degeneration structure and function nervous system. These conditions, including Parkinson's disease (PD), Alzheimer's (AD), Huntington's (HD), Amyotrophic lateral sclerosis (ALS), Multiple (MS), often lead to severe cognitive motor deficits. A critical component neurodegenerative pathologies is imbalance between pro-oxidant antioxidant mechanisms, culminating in oxidative stress. The brain's high oxygen consumption lipid-rich environment make it particularly vulnerable damage. Pro-oxidants such as reactive nitrogen species (RNS) (ROS) are continuously generated during normal metabolism, counteracted enzymatic non-enzymatic defenses. In diseases, this balance disrupted, leading neuronal This systematic review explores roles stress, gut microbiota, epigenetic modifications aiming elucidate interplay these factors identify potential therapeutic strategies. We conducted comprehensive search articles published 2024 across major databases, focusing on studies examining relationships redox homeostasis, changes neurodegeneration. total 161 were included, comprising clinical trials, observational studies, experimental research. Our findings reveal that stress plays central role pathogenesis with microbiota composition significantly influencing balance. Specific bacterial taxa markers identified modulators suggesting novel avenues for intervention. Moreover, recent evidence from human animal supports emerging concept targeting homeostasis through therapies. Future research should focus validating targets settings exploring personalized medicine strategies based individual profiles.

Language: Английский

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Beyond the Swipe: A Review of Photocatalytic Antimicrobial Biocompatible Touchscreen Technology

Applied Materials Today, Journal Year: 2025, Volume and Issue: 44, P. 102697 - 102697

Published: March 30, 2025

Language: Английский

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Linkage of circadian rhythm disruptions with Alzheimer’s disease and therapeutic interventions

Acta Pharmaceutica Sinica B, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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Association between the oxidative balance score and cognitive function: evidence from NHANES 2011-2014

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 16, 2024

Background With the global aging population, prevalence of Cognitive impairment (CI) has significantly increased. Despite extensive research, role oxidative stress in CI remains underexplored, with limited studies directly linking balance score (OBS) to cognitive function. This study aims investigate association between OBS and function using data from 2011–2014 National Health Nutrition Examination Survey (NHANES). Methods Data 2103 participants aged 60 years older were analyzed this study. was calculated 16 dietary components 4 lifestyle factors.Cognitive assessed by a combination tests such as CERAD, AFT DSST. The logistic regression restricted cubic spline (RCS) analyses after adjusting for confounders age, sex, comorbidities. Results Key findings indicate significant positive higher better across all domains, even potential confounders. Subgroup revealed that particularly pronounced individuals liver disease stroke, suggesting might have more detrimental impact on these populations. Conclusion present provides strong evidence is associated adults. Dietary interventions improve may be an effective strategy protect health.

Language: Английский

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New Insights into the Development of Donepezil-Based Hybrid and Natural Molecules as Multi-Target Drug Agents for Alzheimer’s Disease Treatment

Molecules, Journal Year: 2024, Volume and Issue: 29(22), P. 5314 - 5314

Published: Nov. 11, 2024

Alzheimer's disease (AD) involves a complex pathophysiology with multiple interconnected subpathologies, including protein aggregation, impaired neurotransmission, oxidative stress, and microglia-mediated neuroinflammation. Current treatments, which generally target single subpathology, have failed to modify the disease's progression, providing only temporary symptom relief. Multi-target drugs (MTDs) address several aggregation of pathological proteins. In this review, we cover hybrid molecules published between 2014 2024. We offer an overview strategies employed in drug design approaches that led notable improvements reduced hepatotoxicity. Our aim is insights into potential development new drugs. This highlights multi-target featuring heterocycles

Language: Английский

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Neurometabolite, myo-inositol, induces conformational distortion with enhanced aggregation of Carbonic Anhydrase: Implications for altered metabolite levels in Alzheimer's disease

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1325, P. 141054 - 141054

Published: Dec. 9, 2024

Language: Английский

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Chemical profiles and biological activities of essential oils from two endemic species: Stachys sivasica Kit Tan & Yıldız and Stachys cataonica R. Bhattacharjee & Hub. Mor.

Journal of Essential Oil Bearing Plants, Journal Year: 2024, Volume and Issue: 27(6), P. 1504 - 1515

Published: Nov. 1, 2024

Language: Английский

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