Assessment of Pelargonium graveolens flower essential oil: Antimicrobial, antioxidant, enzyme inhibition and in vivo topical analgesic and anti-inflammatory efficacy as treatment for atopic dermatitis DOI Creative Commons
Najlae El-otmani,

Fadoua el ouazzani,

Rania Akoh

et al.

F1000Research, Journal Year: 2024, Volume and Issue: 13, P. 1366 - 1366

Published: Nov. 14, 2024

Background Atopic dermatitis (AD) is a chronic inflammatory skin condition characterized by pruritus and barrier dysfunction. This study aims to evaluate the therapeutic potential of Pelargonium graveolens (Geraniaceae) in managing AD symptoms through its essential oil. Methods The chemical composition flower oil (PFEO) was analyzed using gas chromatography-mass spectrometry (GC-MS). Its antimicrobial, antioxidant, anti-inflammatory properties were assessed, along with inhibitory effects PFEO on key enzymes involved repair: tyrosinase, elastase, collagenase. An vivo evaluation gel formulation containing also conducted assess analgesic efficacy. Results GC-MS analysis identified major compounds PFEO, including Geraniol (22.83%), beta-citronellol (19.51%), naphthalenemethanol (15.36%), Geranyl tiglate (9.38%), minor constituents such as linalool (3.81%) neryl formate (1.31%). exhibited bacteriostatic activity against various bacterial fungal strains, Pseudomonas aeruginosa, Staphylococcus aureus, Methicillin-Resistant aureus (MRSA), Bacillus anthracis, Streptococcus pyogenes, epidermidis, Candida albicans, Malassezia spp. demonstrated significant antioxidant inhibited linked alterations AD. Conclusions shows promising for atopic due properties, well effects. findings support further exploration natural alternative treatment AD.

Language: Английский

Mitigating cyclophosphamide-induced hepatorenal toxicity: Linalool’s role in modulating oxidative stress, inflammation, and apoptosis DOI

Gharam Saad Alserhani,

Maged E. Mohamed, Nancy S. Younis

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

Language: Английский

Citations

0
Assessment of Pelargonium graveolens flower essential oil: Antimicrobial, antioxidant, enzyme inhibition and in vivo topical analgesic and anti-inflammatory efficacy as treatment for atopic dermatitis DOI Creative Commons
Najlae El-otmani,

Fadoua el ouazzani,

Rania Akoh

et al.

F1000Research, Journal Year: 2024, Volume and Issue: 13, P. 1366 - 1366

Published: Nov. 14, 2024

Background Atopic dermatitis (AD) is a chronic inflammatory skin condition characterized by pruritus and barrier dysfunction. This study aims to evaluate the therapeutic potential of Pelargonium graveolens (Geraniaceae) in managing AD symptoms through its essential oil. Methods The chemical composition flower oil (PFEO) was analyzed using gas chromatography-mass spectrometry (GC-MS). Its antimicrobial, antioxidant, anti-inflammatory properties were assessed, along with inhibitory effects PFEO on key enzymes involved repair: tyrosinase, elastase, collagenase. An vivo evaluation gel formulation containing also conducted assess analgesic efficacy. Results GC-MS analysis identified major compounds PFEO, including Geraniol (22.83%), beta-citronellol (19.51%), naphthalenemethanol (15.36%), Geranyl tiglate (9.38%), minor constituents such as linalool (3.81%) neryl formate (1.31%). exhibited bacteriostatic activity against various bacterial fungal strains, Pseudomonas aeruginosa, Staphylococcus aureus, Methicillin-Resistant aureus (MRSA), Bacillus anthracis, Streptococcus pyogenes, epidermidis, Candida albicans, Malassezia spp. demonstrated significant antioxidant inhibited linked alterations AD. Conclusions shows promising for atopic due properties, well effects. findings support further exploration natural alternative treatment AD.

Language: Английский

Citations

0