Antioxidants, Journal Year: 2024, Volume and Issue: 13(12), P. 1502 - 1502
Published: Dec. 10, 2024
Nuclear factor erythroid 2-related 2 (Nrf2) is a crucial regulator of cellular defence mechanisms, essential for maintaining the brain's health. Nrf2 supports mitochondrial function and protects against oxidative damage, which vital meeting substantial energy antioxidant demands. Furthermore, modulates glial inflammatory responses, playing pivotal role in preventing neuroinflammation. This review explores these multifaceted functions within central nervous system, focusing on its activity across various brain cell types, including neurons, astrocytes, microglia, oligodendrocytes. Due to vulnerability stress metabolic challenges, emerging as key therapeutic target enhance resilience stress, inflammation, dysfunction, demyelination, are many neurodegenerative diseases.
Language: Английский