Carbon Monoxide and Prokaryotic Energy Metabolism DOI Open Access
Vitaliy B. Borisov, Elena Forte

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2809 - 2809

Published: March 20, 2025

Carbon monoxide (CO) plays a multifaceted role in both physiology and pathophysiology. At high levels, it is lethal to humans due its tight binding globins cytochrome c oxidase. low doses, CO can exhibit beneficial effects; serves as an endogenous signaling molecule possesses antibacterial properties, which opens up possibilities for use antimicrobial agent. For this purpose, research progress develop metal-based CO-releasing molecules, metal-free organic prodrugs, CO-generating hydrogel microspheres. The energy metabolism of prokaryotes key point that may be targeted by kill invading pathogens. cornerstone prokaryotic series membrane-bound enzyme complexes, constitute respiratory chain. Terminal oxidases, at the end chain, contain hemes are therefore potential targets CO. However, area very early stage. impact on bacterial also provide basis biotechnological applications gas present. This review discusses molecular effects microbial growth aerobic respiration supported different terminal oxidases light recent findings.

Language: Английский

Harnessing Gasotransmitters to Combat Age-Related Oxidative Stress in Smooth Muscle and Endothelial Cells DOI Creative Commons
Constantin Munteanu, Anca‐Irina Galaction, Gelu Onose

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(3), P. 344 - 344

Published: Feb. 27, 2025

Age-related oxidative stress is a critical factor in vascular dysfunction, contributing to hypertension and atherosclerosis. Smooth muscle cells endothelial are particularly susceptible damage, which exacerbates aging through cellular senescence, chronic inflammation, arterial stiffness. Gasotransmitters—hydrogen sulfide (H2S), nitric oxide (NO), carbon monoxide (CO)—are emerging as promising therapeutic agents for counteracting these processes. This review synthesizes findings from recent studies focusing on the mechanisms by H2S, NO, CO influence smooth cell function. Therapeutic strategies involving exogenous gasotransmitter delivery systems combination therapies were analyzed. H2S enhances mitochondrial bioenergetics, scavenges ROS, activates antioxidant pathways. NO improves function, promotes vasodilation, inhibits platelet aggregation. exhibits cytoprotective anti-inflammatory effects modulating heme oxygenase activity ROS production. In preclinical studies, gasotransmitter-releasing molecules (e.g., NaHS, SNAP, CORMs) targeted show significant promise. Synergistic with lifestyle modifications further enhance their potential. conclusion, gasotransmitters hold promise combat age-related cells. Their multifaceted innovative approaches make them potential candidates treating dysfunction promoting healthy aging. Further research needed translate into clinical applications.

Language: Английский

Citations

0
Carbon Monoxide and Prokaryotic Energy Metabolism DOI Open Access
Vitaliy B. Borisov, Elena Forte

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2809 - 2809

Published: March 20, 2025

Carbon monoxide (CO) plays a multifaceted role in both physiology and pathophysiology. At high levels, it is lethal to humans due its tight binding globins cytochrome c oxidase. low doses, CO can exhibit beneficial effects; serves as an endogenous signaling molecule possesses antibacterial properties, which opens up possibilities for use antimicrobial agent. For this purpose, research progress develop metal-based CO-releasing molecules, metal-free organic prodrugs, CO-generating hydrogel microspheres. The energy metabolism of prokaryotes key point that may be targeted by kill invading pathogens. cornerstone prokaryotic series membrane-bound enzyme complexes, constitute respiratory chain. Terminal oxidases, at the end chain, contain hemes are therefore potential targets CO. However, area very early stage. impact on bacterial also provide basis biotechnological applications gas present. This review discusses molecular effects microbial growth aerobic respiration supported different terminal oxidases light recent findings.

Language: Английский

Citations

0