Current Advances in the Therapeutic Potential of Scutellarin: Novel Applications, Mechanisms, and Future Challenges.

Phytomedicine Plus, Journal Year: 2025, Volume and Issue: unknown, P. 100754 - 100754

Published: Jan. 1, 2025

Language: Английский

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A stable double-emulsion system constructed by wheat gluten amyloid fibril and gellan gum: Application for co-delivery of anthocyanins and lutein

Food Hydrocolloids, Journal Year: 2025, Volume and Issue: unknown, P. 111228 - 111228

Published: Feb. 1, 2025

Language: Английский

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Chitosan Nanoparticle-Encapsulated Cordyceps militaris Grown on Germinated Rhynchosia nulubilis Reduces Type II Alveolar Epithelial Cell Apoptosis in PM2.5-Induced Lung Injury

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1105 - 1105

Published: Jan. 27, 2025

Chitosan nanoparticles (CNPs) were synthesized in this study to enhance the limited bioactivity and stability of Cordyceps militaris grown on germinated Rhynchosia nulubilis (GRC) effectively deliver it target tissues. Under optimized conditions, stable encapsulation GRC was achieved by setting chitosan (CHI)-to-tripolyphosphate (TPP) ratio 4:1 adjusting pH TPP 2, resulting a zeta potential +22.77 mV, which indicated excellent stability. As concentration increased, efficiency decreased, whereas loading increased. Fourier-transform infrared (FT-IR) spectroscopy revealed shifts amide I II bands CHI from 1659 1578 1639 cm⁻1, indicating hydrogen bonding successful encapsulated with CNPs (GCN). X-ray diffraction (XRD) examination transition crystalline an amorphous state, further confirming encapsulation. In vivo experiments demonstrated that GCN treatment significantly reduced lung injury scores fine particulate matter (PM2.5)-exposed mice (p < 0.05) alleviated epithelial barrier damage restoring decreased expression occludin protein 0.05). addition, PM2.5-induced upregulation MMP-9 COL1A1 mRNA levels, preventing extracellular matrix (ECM) degradation collagen accumulation exhibited antioxidant effects reducing nitric oxide synthase (iNOS) enhancing both superoxide dismutase (SOD-1) caused PM2.5, thereby alleviating oxidative stress A549 cells, reactive oxygen species (ROS) production compared 0.05), enhanced intracellular uptake confirmed using fluorescence microscopy conclusion, attenuating stress, suppressing apoptosis, preserving integrity. These results emphasize its as therapeutic candidate for treating diseases associated PM2.5 exposure.

Language: Английский

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Effects of Roselle (Hibiscus sabdariffa Linn.) flower extracts on various inflammatory and bone apposition biomarkers during orthodontic tooth movement: An experimental animal study

Journal of Oral Biology and Craniofacial Research, Journal Year: 2025, Volume and Issue: 15(2), P. 412 - 420

Published: Feb. 22, 2025

Language: Английский

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Characterization of Ultrasound-Extracted Pouteria splendens Fruit Extracts: Phytochemical Profiling and Evaluation of Antioxidant and Cytotoxic Effects

Foods, Journal Year: 2025, Volume and Issue: 14(6), P. 908 - 908

Published: March 7, 2025

This study investigated the bioactive potential of Pouteria splendens fruit through ultrasound-assisted extraction, analyzing peel and pulp. The pulp exhibited a higher phytochemical content, with 179.67 mg GAE/g d.w. 208.48 QE/g d.w., approximately 1.5 times more than in peel. Fifty phenolic compounds were identified by HPLC-MS, including four types acids, hydroxybenzoic (52%) hydroxycinnamic (42%) as two predominant ones, six flavonoids, flavonols (26.67%) flavones (23.33%) most prevalent. demonstrated greater antioxidant activity commercial controls (BHA BHT) DPPH assay (IC50 2.54 mg/mL); however, it showed lower FRAP assay. Cytotoxic was evaluated cancerous (MCF-7, HT-29, PC-3) non-cancerous (CCD 841 CoN HEK-293) cell lines. Notably, remarkable cytotoxic against colon cancer cells (HT-29), an IC50 50 µg/mL, possible selectivity not showing significant (CoN HEK). These results suggest that P. splendens, particularly its pulp, is valuable source polyphenols, for food pharmaceutical industries.

Language: Английский

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Therapeutic Potential of Prunus Species in Gastrointestinal Oncology

Cancers, Journal Year: 2025, Volume and Issue: 17(6), P. 938 - 938

Published: March 10, 2025

Background: Gastrointestinal tract cancers represent a significant worldwide health concern, accounting for almost one-third of cancer-related deaths. The existing chemotherapy drugs used in gastrointestinal are ineffective, so prognosis is poor, recurrence and metastasis rates high, survival time remains short, necessitating the development novel antitumor that exhibit low toxicity less potential drug resistance. This challenge considerable, but evidence from past decades supports medicinal properties functionalities bioactive compounds such as flavonoids acid phenolics with anticancer activities. Our purpose was to find data on relationship between cancer Prunus species, focusing their molecular mechanisms action. Results: Studies highlight species modulate cell signaling pathways involved tumorigenesis. Conclusions: studies reviewed suggest polyphenols promising activities could an adjunctive therapeutic strategy treatment. Further necessary validate these compounds’ feasibility cost-effective treatments cancer.

Language: Английский

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Pelargonidin improves functional recovery and attenuates neuropathic pain following spinal cord injury in rats: relevance to its neuroprotective, antioxidant, and anti-inflammatory effects

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 24, 2025

Background Spinal cord injury (SCI) significantly impairs individuals’ sensorimotor functions, hindering daily activities. Current therapeutic options often demonstrate limited efficacy and lead to undesirable side effects. Emerging research highlights the potential of anthocyanins, especially pelargonidin, which possess neuroprotective, anti-inflammatory, antioxidant properties beneficial for neurological conditions. Purpose This study sought explore impact intrathecal administration pelargonidin on recovery sensory-motor functions associated disorders in a rat model SCI through neuroprotective effects regulating inflammatory/oxidative stress mediators. Materials methods In total, 35 male Wistar rats were divided into five groups: sham, SCI, three treatment groups receiving different concentrations (1, 2, 4 mM) once day 0 after surgery/injury. Weight changes assessed behavioral analyses done, including hot plate tests, acetone drop von Frey inclined plane as well Basso, Beattie, Bresnahan (BBB) scores, weekly up 28 post-injury. On 28, serum levels nitrite, catalase, glutathione matrix metalloproteinase (MMP) assays histological evaluations done. Results discussion Pelargonidin attenuated neuropathic pain, improved motor performance, reduced weight loss with SCI. Biochemical demonstrated increased catalase/glutathione level, MMP2 activity, while decreased nitrite level MMP9 activity. Histological showed an enhancement number neurons ventral horn spinal highlighting its neurogenic Conclusion makes substantial benefits following by accelerating recovery. effect is likely due strong antioxidant, properties.

Language: Английский

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Anthocyanins in Black Wolfberry (Lycium ruthenicum Murray): Chemical Structure, Composition, Stability and Biological Activity

Food Reviews International, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 29

Published: March 25, 2025

Language: Английский

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Unlocking the Health Secrets of Onions: Investigating the Phytochemical Power and Beneficial Properties of Different Varieties and Their Parts

Molecules, Journal Year: 2025, Volume and Issue: 30(8), P. 1758 - 1758

Published: April 14, 2025

Onions (Allium cepa L.) are widely consumed worldwide and recognized for their high content of bioactive compounds with potential health benefits. This study investigates the nutritional phytochemical properties three onion varieties—Tropea red onion, yellow onion—analyzed in whole form as well peel pulp. An innovative drying system was employed to assess its impact on retention compounds. The results highlight significant differences nutrient composition among varieties parts. exhibited highest concentrations proteins, phenolic compounds, flavonoids, antioxidants, followed by Tropea stood out superior antioxidant capacity, vitamin C content, acid levels, reinforcing functional food applications. also revealed that mineral particularly calcium, potassium, sulfates, varied across varieties, influencing health-promoting properties. These findings support valorization byproducts sustainability industry. data emphasize need further research processing techniques enhance bioavailability effectiveness onion-derived

Language: Английский

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The Biopotential of Bellardia trixago in Replacing Synthetic Compounds for Health‐Promoting Applications: Is It a Promising Candidate?

Food Science & Nutrition, Journal Year: 2025, Volume and Issue: 13(4)

Published: April 1, 2025

ABSTRACT Bellardia trixago (L.) All. (family Orobanchaceae) is a facultative hemiparasitic plant used traditionally to cure many diseases. The present study was designed evaluate the phenolic constituents, antioxidant, enzyme inhibitory, and cytotoxic properties of aerial parts B. . Ethyl acetate (EtOAc), ethanol (EtOH), 70% EtOH extracts were prepared by maceration, while aqueous extract infusion. Rutin, 4‐hydroxy benzoic acid, ferulic p ‐coumaric hyperoside, delphinidin 3,5 diglucoside, kaempferol, isoquercitrin identified in most with variable concentrations, but generally, or accumulated highest contents. displayed best antiradical (DPPH = 13.55 mg TE/g; ATBS 53.78 TE/g) ion‐reducing (CUPRAC 50.09 FRAP 24.73 properties. recorded chelating iron power (12.91 EDTAE/g) EtOAc exerted total antioxidant activity (2.29 2.49 mmol TE/g, > 0.05). cholinesterase (anti‐AChE 2.91 GALAE/g; anti‐BchE 2.62 GALAE/g) α‐glucosidase (1.19 ACAE/g) inhibition from extract, that against α‐amylase obtained (0.69 ACAE/g). toward HT‐29 cell line, where effect (IC 50 38.42 μg/mL) extract. Furthermore, network pharmacology analysis revealed critical gene targets pathways associated bioactive compounds. Molecular docking studies favorable binding modes interaction patterns major compounds key colon cancer‐related proteins, which further supported molecular dynamics simulations. As first investigation into composition pharmacological effects , this highlights its potential as promising source therapeutic relevance for oxidative stress‐related conditions.

Language: Английский

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