Congestive Heart Failure and Arrhythmias Among Hospitalized Patients With Carcinoid Syndrome DOI Open Access

Etuk Aniekeme,

Bruno Gonçalves, Sneha S. Pillai

et al.

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Introduction Carcinoid syndrome (CS) represents the most common functional in patients with neuroendocrine tumors which may be an advanced tumor state. The pathophysiology of congestive heart failure (CHF) and arrhythmia CS is poorly understood; however, chronic exposure to excessive circulating serotonin considered one important factors contributing increased morbidity mortality this population. Despite recognition, international consensus guidelines specifically addressing diagnosis management CHF are lacking. This study focused on hospitalized once they represent more severe disease states requiring intensive management, thereby providing a clearer understanding influencing adverse clinical outcomes. Methods retrospective cohort utilized Healthcare Cost Utilization Project National Inpatient Sample identify predictors from 2016 2018. Results Initially, total 1,859 were included. After stratification, 606 had variables analyzed using multivariate logistic regression. Among patients, 360 age, male sex, non-Hispanic Black race, Medicare insurance, prolonged hospital stays, all identified as significant predictors. Similarly, 246 diagnosed arrhythmias prevalent older associated hospitalization. Conclusion These results highlight critical patient-related arrhythmia. Strategies aimed at early including scoring systems, biomarker assessment, could improve risk stratification patient Our findings underscore importance targeted interventions mitigate cardiac complications patients. Additionally, incorporating our data into practice has potential promoting timely for CFH Developing managing CS-related complications, based these insights, will further standardize care

Language: Английский

Review of electrophysiological models to study membrane potential changes in breast cancer cell transformation and tumor progression DOI Creative Commons
Chitaranjan Mahapatra,

A. Kishore,

Jineetkumar Gawad

et al.

Frontiers in Physiology, Journal Year: 2025, Volume and Issue: 16

Published: March 5, 2025

The transformation of normal breast cells into cancerous is a complex process influenced by both genetic and microenvironmental factors. Recent studies highlight the significant role membrane potential (Vm) alterations in this transformation. Cancer typically exhibit depolarized resting (RMP) compared to cells, which correlates with increased cellular activity more aggressive cancer behavior. These RMP Vm changes are associated altered ion channel activity, calcium dynamics, mitochondrial dysfunction, modified gap junction communication, disrupted signaling pathways. Such fluctuations influence key processes progression, including cell proliferation, migration, invasion. Notably, subtypes display frequent pronounced fluctuations. Understanding electrical properties provides new insights their behavior offers therapeutic targets, such as channels regulation. This review synthesizes current research on how various factors modulate proposes an electrophysiological model based experimental clinical data from literature. findings may pave way for novel pharmacological targets clinicians, researchers, pharmacologists treating cancer.

Language: Английский

Citations

0
Congestive Heart Failure and Arrhythmias Among Hospitalized Patients With Carcinoid Syndrome DOI Open Access

Etuk Aniekeme,

Bruno Gonçalves, Sneha S. Pillai

et al.

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Introduction Carcinoid syndrome (CS) represents the most common functional in patients with neuroendocrine tumors which may be an advanced tumor state. The pathophysiology of congestive heart failure (CHF) and arrhythmia CS is poorly understood; however, chronic exposure to excessive circulating serotonin considered one important factors contributing increased morbidity mortality this population. Despite recognition, international consensus guidelines specifically addressing diagnosis management CHF are lacking. This study focused on hospitalized once they represent more severe disease states requiring intensive management, thereby providing a clearer understanding influencing adverse clinical outcomes. Methods retrospective cohort utilized Healthcare Cost Utilization Project National Inpatient Sample identify predictors from 2016 2018. Results Initially, total 1,859 were included. After stratification, 606 had variables analyzed using multivariate logistic regression. Among patients, 360 age, male sex, non-Hispanic Black race, Medicare insurance, prolonged hospital stays, all identified as significant predictors. Similarly, 246 diagnosed arrhythmias prevalent older associated hospitalization. Conclusion These results highlight critical patient-related arrhythmia. Strategies aimed at early including scoring systems, biomarker assessment, could improve risk stratification patient Our findings underscore importance targeted interventions mitigate cardiac complications patients. Additionally, incorporating our data into practice has potential promoting timely for CFH Developing managing CS-related complications, based these insights, will further standardize care

Language: Английский

Citations

0