Bioactivity-Guided Isolation of Secondary Metabolites from Camellia fascicularis: Antioxidative Antibacterial Activities and Anti-Inflammatory Hypoglycemic Molecular Docking DOI Creative Commons

Jiandong Tang,

Jingjing Li,

Boxiao Wu

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(21), P. 3435 - 3435

Published: Oct. 28, 2024

Camellia fascicularis is a valuable ornamental, edible, and medicinal plant with promising prospects for bioactivity development. We screened the of eight fractions (Fr. A−I) obtained from ethyl acetate phase C. via silica gel column chromatography. The results indicated that anti-inflammatory, antioxidative, antimicrobial active components were mainly found in Fr. B*, E, A, H; A–G; D–I, respectively. Bioactivity-guided isolation identified 18 secondary metabolites. Compounds 1, 3–5, 7, 15–18 isolated genus first time this study, whereas other compounds also time. structures these elucidated through comprehensive spectroscopic techniques. 9−11, 28, 30, 31 demonstrated antioxidative activities comparable to those ascorbic acid, remaining exhibited diminished activity. In terms activity, 18, 22, 27 exerted inhibitory potency against Pseudomonas aeruginosa, similar tetracycline (MIC: 125 µg/mL). Other showed moderate weak effects Staphylococcus aureus Escherichia coli 250–500 Molecular docking revealed 2, 36, 41, 65 strong binding affinity 8ET0, 38, 40, 63, 3A4A. This research further increased diversity metabolites fascicularis, laying foundation subsequent development utilization species.

Language: Английский

Cebula siedmiolatka (Allium fistulosum L.) - aromatyczna roślina warzywna o znaczeniu żywieniowym, dietetycznym i terapeutycznym DOI Creative Commons
Andrzej Sałata, Renata Nurzyńska-Wierdak

Annales Horticulturae, Journal Year: 2025, Volume and Issue: 33(2), P. 17 - 30

Published: April 3, 2025

Warzywa cebulowe – różne gatunki z rodzaju Allium, f. Alliaceae, wyróżnia wysoka wartość biologiczna. Ich części użytkowe dostarczają organizmowi mało kalorii, ale znaczne ilości witamin, minerałów, przeciwutleniaczy i błonnika pokarmowego. Rodzaj Allium obejmuje wiele gatunków roślin warzywnych o charakterystycznym ostrym, pikantnym smaku, zwykle spożywanych na surowo. Jednym nich jest cebula siedmiolatka (A. fistulosum L.), której łagodny cebulowy smak obecność substancji bioaktywnych sprawiają, że ​​jest wartościowym dodatkiem do różnych potraw. Siedmiolatka ma także bogatą historię w tradycyjnej medycynie dietach. Wartość nutraceutyczna terapeutyczna siedmiolatki zwiększa się zainteresowanie badawcze, a konsumenckie tym warzywem. W niniejszym przeglądzie przedstawiono najważniejsze informacje gatunku A. L.: pochodzenie, biologia, znaczenie kulinarne, odżywcze terapeutyczne, podkreślając korzyści zdrowotne wynikające ze spożywania diet tą aromatyczną rośliną warzywną.

Citations

0
Immunomodulatory effect of allium sativum in type 2 diabetes mellitus DOI
Elva Manuela Mejía Delgado, Juan Eduardo Quiroz‐Aldave, María del Carmen Durand‐Vásquez

et al.

World Journal of Experimental Medicine, Journal Year: 2025, Volume and Issue: 15(2)

Published: April 11, 2025

Type 2 diabetes mellitus (T2DM) is a metabolic disorder marked by chronic hyperglycemia and low-grade inflammation, contributing to various complications. Natural agents with immunomodulatory antioxidant properties have gained attention as adjunct therapies. To review the effects of Allium sativum on inflammatory pathways alterations associated T2DM. A narrative was performed using PubMed/MEDLINE, EMBASE, Scielo databases. The search included terms such “allium sativum”, “inflammation", “oxidative stress”, “diabetes mellitus”. Studies in English Spanish - ranging from clinical trials meta-analyses were selected based relevance. Bioactive compounds allicin, S-allyl cysteine, diallyl disulfide exhibit anti-inflammatory, antioxidant, hypoglycemic, lipid-lowering actions. Preclinical studies show improved glucose metabolism, insulin sensitivity, organ function. Moreover, evidence supports reductions fasting glucose, hemoglobin A1c, blood pressure, oxidative stress, good safety profiles. appears be promising adjuvant T2DM management, offering anti-inflammatory benefits. Nonetheless, further high-quality are needed confirm its long-term efficacy standardize therapeutic use.

Language: Английский

Citations

0
Bioactivity-Guided Isolation of Secondary Metabolites from Camellia fascicularis: Antioxidative Antibacterial Activities and Anti-Inflammatory Hypoglycemic Molecular Docking DOI Creative Commons

Jiandong Tang,

Jingjing Li,

Boxiao Wu

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(21), P. 3435 - 3435

Published: Oct. 28, 2024

Camellia fascicularis is a valuable ornamental, edible, and medicinal plant with promising prospects for bioactivity development. We screened the of eight fractions (Fr. A−I) obtained from ethyl acetate phase C. via silica gel column chromatography. The results indicated that anti-inflammatory, antioxidative, antimicrobial active components were mainly found in Fr. B*, E, A, H; A–G; D–I, respectively. Bioactivity-guided isolation identified 18 secondary metabolites. Compounds 1, 3–5, 7, 15–18 isolated genus first time this study, whereas other compounds also time. structures these elucidated through comprehensive spectroscopic techniques. 9−11, 28, 30, 31 demonstrated antioxidative activities comparable to those ascorbic acid, remaining exhibited diminished activity. In terms activity, 18, 22, 27 exerted inhibitory potency against Pseudomonas aeruginosa, similar tetracycline (MIC: 125 µg/mL). Other showed moderate weak effects Staphylococcus aureus Escherichia coli 250–500 Molecular docking revealed 2, 36, 41, 65 strong binding affinity 8ET0, 38, 40, 63, 3A4A. This research further increased diversity metabolites fascicularis, laying foundation subsequent development utilization species.

Language: Английский

Citations

0