Impact of Melatonin Application in Winemaking on Phenolic Content, Tryptophan Metabolites, and Bioactivity of Red Wine DOI Creative Commons
Neda Đorđević, Nevena Todorović, Ivana Perić

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(5), P. 504 - 504

Published: April 23, 2025

Global wine consumption drives the interest for high-quality with enhanced health benefits. Yeast-produced tryptophan metabolites, including melatonin, a potent antioxidant, emerged as promising agents enhancing functional properties of food and beverages. This study represents pioneering work addressing whether melatonin supplementation during vinification affects Moldova red quality. Total phenolic/flavonoid contents, DPPH, FRAP assays were measured via spectrophotometry, anthocyanins, metabolites using UPLC-MS/MS UPLC-FLD, well cytotoxicity MTT assay. Results showed that addition winemaking process increased total content, antioxidant capacity evidenced by anti-DPPH radical activity. These effects might be due to stimulation phenolic compound biosynthesis, particularly anthocyanins malvidin-3-O-glucoside, peonidin-3-O-glucoside, delphinidin 3-O-glucoside, which found in treated wine. Additionally, revealed melatonin-enriched exhibited against two cancer cell lines, HCT116 PANC-1. Finally, concentration kynurenic acid, which, its cytoprotective properties, could further increase benefits resulting findings offer avenue future research melatonin-driven provide step forward natural product added value.

Language: Английский

Biopolymeric Scaffolds with Melatonin for Tissue Engineering—A Review DOI Open Access

Beata Kaczmarek,

Sylwia Grabska-Zielińska

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2520 - 2520

Published: March 11, 2025

Melatonin, a natural hormone with antioxidant, anti-inflammatory, and regenerative properties, has gained increasing attention in tissue engineering for its ability to enhance the therapeutic potential of biopolymeric scaffolds. These scaffolds, designed mimic extracellular matrix, provide structural support bioactive environment regeneration. By integrating melatonin, researchers aim create multifunctional scaffolds that promote cell proliferation, modulate inflammatory responses, improve wound healing outcomes. Challenges utilizing melatonin include maintaining stability under light, heat, oxygen exposure, optimizing release profile sustained effects. Innovative fabrication methods, such as electrospinning, 3D printing, lyophilization, have enabled precise control over scaffold architecture delivery. techniques ensure enhanced interactions target tissues tailored regeneration processes. Combining growth factors, cytokines, antimicrobial agents offers applications, from chronic management bone nerve Continued research this field promises transformative solutions medicine, expanding clinical applicability melatonin-enriched This review highlights current progress, challenges, opportunities associated harnessing melatonin’s within frameworks.

Language: Английский

Citations

0
Impact of Melatonin Application in Winemaking on Phenolic Content, Tryptophan Metabolites, and Bioactivity of Red Wine DOI Creative Commons
Neda Đorđević, Nevena Todorović, Ivana Perić

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(5), P. 504 - 504

Published: April 23, 2025

Global wine consumption drives the interest for high-quality with enhanced health benefits. Yeast-produced tryptophan metabolites, including melatonin, a potent antioxidant, emerged as promising agents enhancing functional properties of food and beverages. This study represents pioneering work addressing whether melatonin supplementation during vinification affects Moldova red quality. Total phenolic/flavonoid contents, DPPH, FRAP assays were measured via spectrophotometry, anthocyanins, metabolites using UPLC-MS/MS UPLC-FLD, well cytotoxicity MTT assay. Results showed that addition winemaking process increased total content, antioxidant capacity evidenced by anti-DPPH radical activity. These effects might be due to stimulation phenolic compound biosynthesis, particularly anthocyanins malvidin-3-O-glucoside, peonidin-3-O-glucoside, delphinidin 3-O-glucoside, which found in treated wine. Additionally, revealed melatonin-enriched exhibited against two cancer cell lines, HCT116 PANC-1. Finally, concentration kynurenic acid, which, its cytoprotective properties, could further increase benefits resulting findings offer avenue future research melatonin-driven provide step forward natural product added value.

Language: Английский

Citations

0