Association of triglyceride-glucose index and derived indices with cataract in middle-aged and elderly Americans: NHANES 2005–2008

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: Feb. 14, 2025

Abstract Aim Explore the relationship between triglyceride-glucose (TyG) index, along with its derivative indices, and prevalence of cataracts. Methods Data from 20,497 participants in 2005–2008 National Health Nutrition Examination Survey (NHANES) were compiled. A final total 4,499 individuals met eligibility criteria. Cataract presence was assessed through a self-reported history cataract surgery. The TyG index derivatives—TyG-waist-to-height ratio (WHtR), TyG-neutrophil-to-lymphocyte (NLR), TyG-monocyte-to-lymphocyte (MLR), TyG-log platelet-to-lymphocyte (lgPLR), systemic inflammation (lgSII), TyG-systemic response (SIRI)—were calculated. Statistical analyses included multivariable logistic regression, restricted cubic spline (RCS) curves for nonlinear relationships, receiver operating characteristic (ROC) analysis. Results Higher indices significantly associated ( P < 0.001). Specifically, TyG-WHtR, TyG-NLR, TyG-lgPLR, TyG-lgSII, TyG-SIRI exhibited positive correlations prevalence, even after adjustment potential confounders (odds [OR] = 1.17; 95% confidence interval [CI]: 1.01, 1.37; 0.0403; 1.01; 1.00, 1.02; 0.0258; 1.08; 1.16; 0.0223; 1.03, 1.14; 0.001; 1.04; 0.0120). Furthermore, stratified analysis showed that 61–85 age group, TyG-lgPLR TyG-lgSII remained positively ([OR] 1.09; 0.024; 1.02, 1.13; 0.005). RCS revealed linear association these cataracts, no apparent threshold effect. ROC indicated TyG-MLR demonstrated highest predictive ability presence. Conclusion study results indicate TyG-related indicators cataracts middle-aged elderly individuals, suggesting markers may serve as practical biomarkers identifying high-risk individuals. Early detection management metabolic inflammatory factors could contribute to effective preventive strategies development population.

Language: Английский

Association Between Visceral Fat Metabolism Score and Cataract Risk in US Adults: National Health and Nutrition Examination Survey 1999-2008

American Journal of Ophthalmology, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский