Prenatal melatonin reprograms liver injury in male pups caused by maternal exposure to a high-fat diet and microplastics DOI Creative Commons
Yu-Jen Chen, Hong‐Ren Yu, Ching‐Chou Tsai

et al.

APOPTOSIS, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

Prenatal exposure to a high-fat diet (HFD) or microplastics can impact liver fat accumulation in offspring. This study investigates the protective effects of prenatal melatonin on injury male pups resulting from maternal HFD and microplastics. Pregnant Sprague-Dawley rats were fed either an normal chow diet, with some groups exposed alone combination melatonin. Male evaluated postnatal day 7. Results indicated that HFD-microplastics group (HFD-Mi) exhibited increased lipid (observed histological staining), apoptosis (elevated cleaved caspase 3, phospho-AKT, TUNEL inflammation (higher IL- 6 TNF-α), oxidative stress malondialdehyde). Conversely, treatment (HFD-Mi + M) significantly reduced these effects, including accumulation, apoptosis, inflammation, while enhancing antioxidant enzyme glutathione peroxidase activity improving metabolism (reduced SREBP- 1 expression). These findings suggest mitigates caused by through its anti-inflammatory, antioxidative, lipid-regulating properties, underscoring potential hepatoprotective role.

Language: Английский

Prenatal melatonin reprograms liver injury in male pups caused by maternal exposure to a high-fat diet and microplastics DOI Creative Commons
Yu-Jen Chen, Hong‐Ren Yu, Ching‐Chou Tsai

et al.

APOPTOSIS, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

Prenatal exposure to a high-fat diet (HFD) or microplastics can impact liver fat accumulation in offspring. This study investigates the protective effects of prenatal melatonin on injury male pups resulting from maternal HFD and microplastics. Pregnant Sprague-Dawley rats were fed either an normal chow diet, with some groups exposed alone combination melatonin. Male evaluated postnatal day 7. Results indicated that HFD-microplastics group (HFD-Mi) exhibited increased lipid (observed histological staining), apoptosis (elevated cleaved caspase 3, phospho-AKT, TUNEL inflammation (higher IL- 6 TNF-α), oxidative stress malondialdehyde). Conversely, treatment (HFD-Mi + M) significantly reduced these effects, including accumulation, apoptosis, inflammation, while enhancing antioxidant enzyme glutathione peroxidase activity improving metabolism (reduced SREBP- 1 expression). These findings suggest mitigates caused by through its anti-inflammatory, antioxidative, lipid-regulating properties, underscoring potential hepatoprotective role.

Language: Английский

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