Effects of Blueberry Consumption on Fecal Microbiome Composition and Circulating Metabolites, Lipids, and Lipoproteins in a Randomized Controlled Trial of Older Adults with Overweight or Obesity: The BEACTIVE Trial

Nutrients, Journal Year: 2025, Volume and Issue: 17(7), P. 1200 - 1200

Published: March 29, 2025

Background/Objectives: Generous consumption of phytonutrient-rich foods, including blueberries, provides benefits to multiple physiologic and metabolic systems. This study explored the potential that regular, generous blueberry intake could favorably modulate fecal microbiome composition in sedentary older (>60 years) men women with overweight or obesity (BMI ≥ 25 32 kg/m2). Methods: Participants (n = 55) were randomized daily either lyophilized powder (equivalent 1.5 cups blueberries) an indistinguishable placebo powder; both groups participated weekly supervised exercise classes. Fecal samples collected at 0 12 weeks frozen. Following this, 16S rRNA gene sequencing was used profile each participant's microbiome. Blood biomarkers cardiometabolic health measured via nuclear magnetic resonance spectroscopy (NMR) pre- post-treatment. Results: Comparing baseline endpoint results for 15) 19) groups, there no significant overall compositional differences level diversity However, subjects whose diet included powder, a enrichment (p 0.049) relative abundance Coriobacteriales incertae sedis, taxonomic group bacteria facilitates metabolism dietary polyphenols. The exhibited reductions total cholesterol, LDL-C, non-HDL-C, LDL-P, large ApoB, while HDL-P ApoA-I after compared baseline. Conclusions: may upregulate ability human gut utilize polyphenols by altering Longer, larger-scale studies blueberries are needed observe improvements risk factors adults obesity.

Language: Английский

Investigating the neuroprotective effects of strawberry extract against diesel soot-induced motor dysfunction in Drosophila: an in-vivo and in-silico study

In Silico Pharmacology, Journal Year: 2025, Volume and Issue: 13(2)

Published: April 16, 2025

Language: Английский

Studies on the mechanism of ototoxic action of cisplatin and the antagonistic effect of polyphenolic compounds

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 25, 2025

Cisplatin is a highly effective broad-spectrum anticancer drug, but its severe ototoxicity limits clinical application. mainly manifested as irreversible hearing loss, and mechanism involves various pathways such DNA damage, oxidative stress, inflammatory response, mitochondrial dysfunction, ferroptosis. In recent years, natural polyphenols have shown great potential in combating cisplatin due to their powerful antioxidant, anti-inflammatory anti-apoptotic properties.A variety of polyphenolic compounds, resveratrol, curcumin, quercetin, etc., can effectively attenuate the damage on Corti organs, spiral ganglion neurons vascular striatum by scavenging free radicals, inhibiting release factors, regulating expression apoptosis-related proteins. addition, some enhance anti-tumour effect while antagonizing ototoxicity.Although show good application prospects prevention treatment ototoxicity, there are still problems that need be solved, low bioavailability polyphenols, action has not yet been fully elucidated, optimal dosing regimen determined, whether any superimposed combining types oral exert an otoprotective through regulation intestinal flora intestinal-auricular axis.This study provides new insights into drug candidates for CIO summarising cytotoxic mechanisms targeting these order retard progression CIO. It ideas approaches next step focusing development low-toxic control ototoxicity.

Language: Английский