Melatonin-Mediated Protection against Sepsis-Induced Organ Dysfunction

IntechOpen eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

Sepsis-induced organ dysfunction represents a critical challenge in intensive care medicine, characterized by complex pathophysiological mechanisms that can lead to multiple failure and death. This review examines the fundamental underlying sepsis-induced explores therapeutic potential of melatonin, multifaceted molecule with potent antioxidant anti-inflammatory properties. We analyzed pathways involved damage during sepsis, including inflammatory cascades, oxidative stress, mitochondrial dysfunction, endothelial injury. Special attention is given melatonin’s protective effects on various systems, cardiac, pulmonary, renal, hepatic, central nervous system function sepsis. Recent evidence suggests ability modulate these pathways, combined its excellent safety profile, makes it promising agent sepsis management. Understanding applications may provide new strategies for improving outcomes septic patients.

Language: Английский

Neuro-Nutritional Approach to Neuropathic Pain Management: A Critical Review

Nutrients, Journal Year: 2025, Volume and Issue: 17(9), P. 1502 - 1502

Published: April 29, 2025

Pain is a significant global public health issue that can interfere with daily activities, sleep, and interpersonal relationships when it becomes chronic or worsens, ultimately impairing quality of life. Despite ongoing efforts, the efficacy pain treatments in improving outcomes for patients remains limited. At present, challenge lies developing personalized care management plan helps to maintain patient activity levels effectively manages pain. Neuropathic condition resulting from damage somatosensory nervous system, significantly impacting It partly thought be caused by inflammation oxidative stress, clinical research has suggested link between this diet. However, these links are not yet well understood require further investigation evaluate pathways involved neuropathic Specifically, question whether supplementation dietary antioxidants, such as melatonin, could serve potential adjunctive treatment modulation. Melatonin, primarily secreted pineal gland but also produced other systems digestive known its anti-inflammatory, antioxidant, anti-aging properties. found various fruits vegetables, presence alongside polyphenols foods may enhance melatonin intake contribute improved health. The aim review provide an overview examine role neuro-nutritional approach management.

Language: Английский