Lactococcus lactis Subsp. lactis LL-1 and Lacticaseibacillus paracasei LP-16 Influence the Gut Microbiota and Metabolites for Anti-Obesity and Hypolipidemic Effects in Mice DOI Creative Commons
Peng Gao, Yuanyang Nie, Lili Zhao

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(5), P. 547 - 547

Published: May 1, 2025

This study utilized a high-fat diet-induced obese male C57BL/6 mice model to investigate the anti-obesity and lipid-lowering effects of Lactococcus lactis subsp. LL-1 Lacticaseibacillus paracasei LP-16. A gut microbiota analysis via 16S rRNA sequencing, along with measurements body weight, lipids, inflammation markers, metabolites, revealed that lactic acid bacteria (LAB) significantly reduced blood lipid levels, liver oxidative stress. They also enhanced diversity evenness, potentially by modulating Firmicutes/Bacteroidetes ratio limit excess energy absorption. Malondialdehyde (MDA) showed extremely significant positive correlations Lachnospiraceae, Blautia, Colidextribacter, correlation Helicobacter, while superoxide dismutase (SOD) glutathione peroxidase (GSH-Px) exhibited opposite trends. Specifically, Muribaculaceae, Bacteroides, Lactobacillus negative MDA levels SOD GSH-Px. Short-chain fatty acids (SCFAs) positively correlated Mucispirillum, Lactobacillus, but negatively Alistipes, Helicobacter. increased SCFA promoting beneficial reducing pathogens, alleviating obesity hyperlipidemia. Additionally, they regulated microbiota, decreasing bile long-chain increasing SCFAs, short peptides, vitamins, thereby improving metabolic disorders enhancing host health.

Language: Английский

Cutting edge: ferroptosis in metabolic dysfunction-associated steatotic liver disease (MASLD) pathogenesis and therapy DOI

Amr Ali Mohamed Abdelgawwad El-Sehrawy,

Teeba Ammar Rashid,

Muhammad Ikram Ullah

et al.

Functional & Integrative Genomics, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 25, 2025

Language: Английский

Citations

0
Lactococcus lactis Subsp. lactis LL-1 and Lacticaseibacillus paracasei LP-16 Influence the Gut Microbiota and Metabolites for Anti-Obesity and Hypolipidemic Effects in Mice DOI Creative Commons
Peng Gao, Yuanyang Nie, Lili Zhao

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(5), P. 547 - 547

Published: May 1, 2025

This study utilized a high-fat diet-induced obese male C57BL/6 mice model to investigate the anti-obesity and lipid-lowering effects of Lactococcus lactis subsp. LL-1 Lacticaseibacillus paracasei LP-16. A gut microbiota analysis via 16S rRNA sequencing, along with measurements body weight, lipids, inflammation markers, metabolites, revealed that lactic acid bacteria (LAB) significantly reduced blood lipid levels, liver oxidative stress. They also enhanced diversity evenness, potentially by modulating Firmicutes/Bacteroidetes ratio limit excess energy absorption. Malondialdehyde (MDA) showed extremely significant positive correlations Lachnospiraceae, Blautia, Colidextribacter, correlation Helicobacter, while superoxide dismutase (SOD) glutathione peroxidase (GSH-Px) exhibited opposite trends. Specifically, Muribaculaceae, Bacteroides, Lactobacillus negative MDA levels SOD GSH-Px. Short-chain fatty acids (SCFAs) positively correlated Mucispirillum, Lactobacillus, but negatively Alistipes, Helicobacter. increased SCFA promoting beneficial reducing pathogens, alleviating obesity hyperlipidemia. Additionally, they regulated microbiota, decreasing bile long-chain increasing SCFAs, short peptides, vitamins, thereby improving metabolic disorders enhancing host health.

Language: Английский

Citations

0