Update on the correlation between mitochondrial function and osteonecrosis of the femoral head osteocytes DOI Creative Commons
C. Y. Li,

Hangyu Ji,

Suyang Zhuang

et al.

Redox Report, Journal Year: 2025, Volume and Issue: 30(1)

Published: April 18, 2025

Mitochondrial health is maintained in a steady state through mitochondrial dynamics and autophagy processes. Recent studies have identified healthy mitochondria as crucial regulators of cellular function survival. This process involves adenosine triphosphate (ATP) synthesis by oxidative phosphorylation (OXPHOS), regulation calcium metabolism inflammatory responses, intracellular stress management. In the skeletal system, they participate behaviors responses osteoblasts, osteoclasts, chondrocytes, osteocytes to external stimuli. Indeed, damage or dysfunction occurs development few bone diseases. For example, may lead an imbalance osteoblasts resulting osteoporosis, osteomalacia, poor production, chondrocyte death infiltration osteoarthritis are main causes cartilage degeneration due damage. However, opposite exists for osteosarcoma, where overactive able accelerate proliferation migration osteosarcoma cells, which major disease feature. Bone dynamic organ play fundamental role all regions tissue involved regulating integrity. review examines impact physiological on osteocyte summarizes microscopic molecular mechanisms underlying its effects. It highlights that targeted therapies focusing be beneficial survival, providing new insight diagnosis, prevention, treatment diseases associated with death.

Language: Английский

Update on the correlation between mitochondrial function and osteonecrosis of the femoral head osteocytes DOI Creative Commons
C. Y. Li,

Hangyu Ji,

Suyang Zhuang

et al.

Redox Report, Journal Year: 2025, Volume and Issue: 30(1)

Published: April 18, 2025

Mitochondrial health is maintained in a steady state through mitochondrial dynamics and autophagy processes. Recent studies have identified healthy mitochondria as crucial regulators of cellular function survival. This process involves adenosine triphosphate (ATP) synthesis by oxidative phosphorylation (OXPHOS), regulation calcium metabolism inflammatory responses, intracellular stress management. In the skeletal system, they participate behaviors responses osteoblasts, osteoclasts, chondrocytes, osteocytes to external stimuli. Indeed, damage or dysfunction occurs development few bone diseases. For example, may lead an imbalance osteoblasts resulting osteoporosis, osteomalacia, poor production, chondrocyte death infiltration osteoarthritis are main causes cartilage degeneration due damage. However, opposite exists for osteosarcoma, where overactive able accelerate proliferation migration osteosarcoma cells, which major disease feature. Bone dynamic organ play fundamental role all regions tissue involved regulating integrity. review examines impact physiological on osteocyte summarizes microscopic molecular mechanisms underlying its effects. It highlights that targeted therapies focusing be beneficial survival, providing new insight diagnosis, prevention, treatment diseases associated with death.

Language: Английский

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