Exploring scraping therapy: Contemporary views on an ancient healing – A review

Journal of Family Medicine and Primary Care, Journal Year: 2021, Volume and Issue: 10(8), P. 2757 - 2762

Published: Aug. 27, 2021

Gua sha is a traditional healing technique that aims to create petechiae on the skin for believed therapeutic benefit. Natural healings are mostly based repeated observations and anecdotal information. Hypothetical model does not always fit modern understanding. Yet, mechanisms underlying Sha have been empirically established. Contemporary scientific research can now explain some events of therapies were once mystery. It assumed therapy serve as mechanical signal enhance immune surveillance function during natural resolving petechiae, through which scraping may result in benefits. The current review, without judging past hypothetical model, attempts interpret experience ancient terms contemporary views concepts.

Language: Английский

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Gases in Sepsis: Novel Mediators and Therapeutic Targets

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(7), P. 3669 - 3669

Published: March 27, 2022

Sepsis, a potentially lethal condition resulting from failure to control the initial infection, is associated with dysregulated host defense response pathogens and their toxins. Sepsis remains leading cause of morbidity, mortality disability worldwide. The pathophysiology sepsis very complicated not yet fully understood. Worse still, development effective therapeutic agents still an unmet need great challenge. Gases, including nitric oxide (NO), carbon monoxide (CO) hydrogen sulfide (H2S), are small-molecule biological mediators that endogenously produced, mainly by enzyme-catalyzed reactions. Accumulating evidence suggests these gaseous widely involved in sepsis. Many sepsis-associated alterations, such as elimination invasive pathogens, resolution disorganized inflammation preservation function multiple organs systems, shaped them. Increasing attention has been paid developing approaches targeting molecules for sepsis/septic shock, taking advantage actions played NO, CO H2S. Several preliminary studies have identified promising strategies gaseous-mediator-based treatments In this review article, we summarize state-of-the-art knowledge on sepsis; metabolism physiological H2S; crosstalk among mediators; crucial effects progression addition, also briefly discuss prospect interventions

Language: Английский

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Mechanisms of Resistance to Photodynamic Therapy (PDT) in Vulvar Cancer

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(8), P. 4117 - 4117

Published: April 8, 2022

Photodynamic therapy (PDT) is a valuable treatment method for vulvar intraepithelial neoplasia (VIN). It allows the of multifocal disease with minimal tissue destruction. 5-Aminolevulinic acid (5-ALA) most commonly used prodrug, which converted in heme pathway to protoporphyrin IX (PpIX), an actual photosensitizer (PS). Unfortunately, not all patients treated PDT undergo complete remission. The main cause their failure resistance anticancer therapy. In many cancers, various treatments correlated increased activity DNA repair protein apurinic/apyrimidinic endonuclease 1 (APE1). Enhanced drug pumps may also affect effectiveness To investigate whether multidrug mechanisms underlie VIN, porphyrins were isolated from sensitive and resistant cancer cells culture media. APE1 was measured, survival assay after combined inhibitor performed. Our results revealed that accumulated effluxed less than cells, response PDT, activity. Moreover, inhibition significantly decreased PDT-resistant cells. This means be result alterations synthesis pathway. essential PDT-mediated damage, increase efficacy PDT.

Language: Английский

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Heme induced progesterone-resistant profiling and promotion of endometriosis in vitro and in vivo

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2023, Volume and Issue: 1869(7), P. 166761 - 166761

Published: May 27, 2023

Language: Английский

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New Insights into Reductive Stress Responses and its Clinical Relation in Cancer

Tissue and Cell, Journal Year: 2025, Volume and Issue: 93, P. 102736 - 102736

Published: Jan. 10, 2025

Language: Английский

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