Frontiers in Toxicology,
Journal Year:
2021,
Volume and Issue:
3
Published: Sept. 29, 2021
Humans
are
exposed
to
micro
and
nanoplastics
(MNPLs)
through
inhalation,
ingestion
and,
a
lesser
extent,
dermal
contact.
In
recent
years,
new
insights
indicate
the
potential
of
MNPLs
cause
damages
human
health.
Particle
toxicity
can
include
oxidative
stress,
inflammatory
lesions,
then
increased
internalization
or
translocation
tissues.
On
other
hand,
plastic
additives
used
in
particles,
once
internalized,
release
toxic
substances.
It
is
noteworthy
that
effects
encompass
wide
range
polymers
chemical
additives,
showing
various
physicochemical
toxicological
properties,
size,
shape
surface
properties
variables
influencing
their
effects.
spite
research
carried
out
recently,
its
early
stages,
further
investigation
required.
this
review
article,
knowledge
exposure
routes
results
on
health
presented
discussed.
Finally,
current
limitations
main
gaps
body
summarised.
Frontiers in Chemistry,
Journal Year:
2024,
Volume and Issue:
12
Published: Oct. 7, 2024
Oxidative
species,
generated
endogenously
via
metabolism
or
from
exogenous
sources,
play
crucial
roles
in
the
body.
At
low
levels,
these
species
support
immune
functions
by
participating
phagocytosis.
They
also
aid
cellular
signaling
and
contribute
to
vasomodulation.
However,
when
levels
of
oxidative
exceed
body’s
antioxidant
capacity
neutralize
them,
stress
occurs.
This
can
damage
macromolecules
such
as
lipids,
DNA,
RNA,
proteins,
driving
pathogenesis
diseases
aging
through
progressive
deterioration
physiological
structures.
Therefore,
ability
manage
maintain
it
at
optimal
is
essential
for
overall
health.
Understanding
fundamentals
stress,
along
with
its
reliable
quantification,
enable
consistency
comparability
clinical
practice
across
various
diseases.
While
direct
quantification
oxidant
body
would
be
ideal
assessing
not
feasible
due
their
high
reactivity,
short
half-life,
challenges
using
conventional
techniques.
Alternatively,
quantifying
lipid
peroxidation,
products
nucleic
acids
well
endogenous
antioxidants,
serves
appropriate
markers
indicating
degree
Along
markers,
this
review
discusses
role
novel
focusing
on
biological
samples
detection
Effective
may
enhance
understanding
phenomenon,
aiding
maintenance
integrity,
prevention
age-associated
diseases,
promotion
longevity.
Gels,
Journal Year:
2025,
Volume and Issue:
11(1), P. 33 - 33
Published: Jan. 3, 2025
Cordyceps
militaris
is
a
medicinal
mushroom
widely
utilized
in
traditional
East
Asian
medicine,
recognized
for
its
diverse
therapeutic
properties.
This
review
explores
the
potential
of
C.
militaris-derived
bioactive
gels
applications
dermatology
and
skincare,
with
particular
focus
on
their
anti-aging
benefits.
In
response
to
rising
incidence
skin
cancers
growing
demand
natural
ingredients,
has
emerged
as
valuable
source
functional
compounds,
including
cordycepin,
polysaccharides,
adenosine.
These
compounds
exhibit
multiple
bioactivities,
apoptosis
induction,
cell
cycle
arrest,
anti-inflammatory
effects,
which
have
been
shown
be
particularly
effective
against
melanoma
other
cancers.
Additionally,
antioxidant
properties
enhance
resilience
by
scavenging
reactive
oxygen
species,
reducing
oxidative
stress,
promoting
collagen
synthesis,
thereby
addressing
health
requirements.
The
incorporating
into
gel-based
formulations
skincare
also
examined,
either
standalone
bioactives
or
combination
synergistic
ingredients.
Emphasis
placed
necessity
clinical
trials
standardization
establish
safety,
efficacy,
reproducibility
such
applications.
By
providing
safer
alternative
synthetic
agents,
represent
promising
advancement
skincare.
Biomolecules,
Journal Year:
2020,
Volume and Issue:
10(8), P. 1105 - 1105
Published: July 25, 2020
Bisphenol
A
(BPA)
is
an
oestrogenic
endocrine
disruptor
widely
used
in
the
production
of
certain
plastics,
e.g.,
polycarbonate,
hard
and
clear
epoxy
resins
that
act
as
protective
coating
for
food
beverage
cans.
Human
exposure
to
this
chemical
thought
be
ubiquitous.
BPA
alters
function,
thereby
causing
many
diseases
human
animals.
In
last
few
decades,
studies
exploring
mechanism
activity
revealed
a
direct
link
between
BPA-induced
oxidative
stress
disease
pathogenesis.
Antioxidants,
reducing
agents
prevent
cellular
oxidation
reactions,
can
protect
toxicity.
Although
important
role
antioxidants
minimizing
has
been
demonstrated
studies,
consensus
on
associated
mechanisms
needed,
well
directives
their
efficacy
safety.
Herein,
considering
distinct
biochemical
properties
antioxidants,
we
provide
framework
understanding
how
alleviate
BPA-associated
stress.
We
summarize
current
knowledge
biological
function
enzymatic
non-enzymatic
discuss
practical
potential
BPA-detoxifying
agents.
Frontiers in Toxicology,
Journal Year:
2021,
Volume and Issue:
3
Published: Sept. 29, 2021
Humans
are
exposed
to
micro
and
nanoplastics
(MNPLs)
through
inhalation,
ingestion
and,
a
lesser
extent,
dermal
contact.
In
recent
years,
new
insights
indicate
the
potential
of
MNPLs
cause
damages
human
health.
Particle
toxicity
can
include
oxidative
stress,
inflammatory
lesions,
then
increased
internalization
or
translocation
tissues.
On
other
hand,
plastic
additives
used
in
particles,
once
internalized,
release
toxic
substances.
It
is
noteworthy
that
effects
encompass
wide
range
polymers
chemical
additives,
showing
various
physicochemical
toxicological
properties,
size,
shape
surface
properties
variables
influencing
their
effects.
spite
research
carried
out
recently,
its
early
stages,
further
investigation
required.
this
review
article,
knowledge
exposure
routes
results
on
health
presented
discussed.
Finally,
current
limitations
main
gaps
body
summarised.
