Effects of a Nanoencapsulated Moringa Leaf Ethanolic Extract on the Physiology, Metabolism and Reproductive Performance of Rabbit Does during Summer

Antioxidants, Journal Year: 2021, Volume and Issue: 10(8), P. 1326 - 1326

Published: Aug. 23, 2021

This study investigated the effect of Moringa leaf ethanolic extract (MLEE) on heat-tolerance variables and reproductive performance rabbit does bred under hot climate conditions. Additionally, nanoencapsulation technology biological efficiency MLEE was considered. A total 56 were randomly divided into four experimental groups treated with 50 mg/kg body weight (BW) nonencapsulated MLEE, 25 or 10 BW nanoencapsulated not (Control, C). The treatments continued for days, including mating pregnancy times. Physiological hematochemical variables, hormonal profiles, (kindling rate litter characteristics) determined. active components identified. results indicated that has 30 components. All MLEE-based reduced heat-stress-related indicators, such as rectal temperatures, respiratory rates heart rate; improved attributes, redox status, hormones (progesterone prolactin); increased size, kindling rate, size at birth birth. Adding can alleviate negative impacts heat stress by improving metabolism, balance during pregnancy. These effects seen whether MLLE in free encapsulated forms. However, use allowed 80% reduction (10 BW) optimal dose (50 without affecting treatment. support importance bioavailability when they are orally administered.

Language: Английский

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The multiple actions of grape and its polyphenols on female reproductive processes with an emphasis on cell signalling

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 4, 2024

Grapes are an economically important fruit crop, and their polyphenols (mainly phenolic acids, flavanols, flavonols, anthocyanins, proanthocyanidins, stilbenes) can exert a wide range of health benefits as interesting valuable dietary supplement for natural complementary therapy. However, potential physiological therapeutic actions on reproductive processes have not been sufficiently elucidated. This evidence-based study presents current knowledge grape extracts polyphenols, well properties therapeutical in relation to female reproduction nutshell. Grape extract, its such resveratrol, proanthocyanidin B2 or delphinidin may influence physiology pathology, regulate multiple signaling pathways related hormones, steroid hormones receptors, intracellular regulators oxidative stress subsequent inflammation, apoptosis, proliferation. Their role the management ovarian cancer, age-related insufficiency, ischemia, PCOS, menopausal syndrome has indicated. In particular, involvement grapeseed and/or steroidogenesis, oocyte maturation, developmental capacity implicated, albeit at different regulatory levels. posing extract focuses various levels signalling by regulating (GnRH, gonadotropins, prolactin, IGFBP), markers proliferation apoptosis. lack standardized dosages so far limits clinical application despite biological potentials.

Language: Английский

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Dietary fiber, polyphenols and sensory and technological acceptability in sliced bread made with mango peel flour

Brazilian journal of food technology/Brazilian Journal of Food Technology, Journal Year: 2024, Volume and Issue: 27

Published: Jan. 1, 2024

Abstract The use of mango peel, an agro-industrial byproduct rich in bioactive compounds, was the subject this study, seeking innovative application manufacture sliced bread. This process is proposed as a way to create nutritious and healthy food, dietary fiber total polyphenols. Mango peel flour Kent variety obtained by drying, grinding, sieving. An experimental design through Response Surface Methodology (RSM) with central composite rotatable design, used evaluate impact (5% to15%) ascorbic acid (20 to100 ppm) bread formulation. Technological, sensory evaluations, determinations polyphenols were carried out, using standard methods. results showed that influence texture bread, formulations 10% 60 ppm obtaining best ratings color, appearance, aroma, texture. increased up 13.25 g/100 g 1.187 AGE/g dry weight (DW) These findings suggest inclusion improves nutritional quality showing its potential functional ingredient food industry.

Language: Английский

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Prevention of Male Late-Onset Hypogonadism by Natural Polyphenolic Antioxidants

Nutrients, Journal Year: 2024, Volume and Issue: 16(12), P. 1815 - 1815

Published: June 9, 2024

Androgen production primarily occurs in Leydig cells located the interstitial compartment of testis. In aging males, testosterone is crucial for maintaining muscle mass and strength, bone density, sexual function, metabolic health, energy levels, cognitive as well overall well-being. As men age, by testes begins to decline at a rate approximately 1% per year starting from their 30s. This review highlights recent findings concerning use natural polyphenolics compounds, such flavonoids, resveratrol, phenolic acids, enhance production, thereby preventing age-related degenerative conditions associated with insufficiency. Interestingly, most polyphenolic antioxidants having beneficial effects on tend expression steroidogenic acute regulatory protein (Star) gene cells. The STAR facilitates entry steroid precursor cholesterol inside mitochondria, rate-limiting step androgen biosynthesis. Natural compounds can also improve activities enzymes, hypothalamus-pituitary gland axis signaling, bioavailability. Thus, many luteolin, quercetin, ferulic acid phenethyl ester or gigantol may be promising delaying initiation late-onset hypogonadism accompanying males.

Language: Английский

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Antioxidant and Antimicrobial Activity of Cleome droserifolia (Forssk.) Del. and Its Biological Effects on Redox Status, Immunity, and Gut Microflora

Animals, Journal Year: 2021, Volume and Issue: 11(7), P. 1929 - 1929

Published: June 28, 2021

This study aimed to investigate the antioxidant, antimicrobial, and immunomodulatory activities of a Cleome droserifolia (Forssk.) Del. (Cd) shoot methanolic extracts considering biological activity its phytogenic compounds. For this purpose, Cd phenolic compounds were detected, an in vitro evaluation antioxidant antimicrobial extract was performed. evaluation, 30 v-line rabbits randomly distributed into three groups with treatments including: basal diet without shoots powder supplement (C group) or supplemented 1.25- (Cdl 2.5 (Cdh group)-mg Cd/kg dry matter (DM). The showed linear scavenging for 2,2-diphenyl-1-picrylhydrazyl 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid), maximal observed at concentration 1 mg/mL. A total 16 identified by reverse-phase high-performance liquid chromatography (RP-HPLC) extract, among which benzoic acid, rutin, ellagic naringenin, o-coumaric acid major inhibitory actions against microbial pathogen species. vivo that two concentrations significantly improved redox status blood plasma lysozyme activity. Treatment Cdh decreased levels interleukin-β1 compared control. Moreover, increased counts intestinal cecal yeast Lactobacillus species Salmonella Coliform aerial parts shrub had strong activities, can improve overall health seem be related impressive range biologically active

Language: Английский

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The Role of Genistein in Mammalian Reproduction

Molecules, Journal Year: 2023, Volume and Issue: 28(21), P. 7436 - 7436

Published: Nov. 5, 2023

Genistein is a natural compound belonging to flavonoids, having antioxidant, anti-inflammatory, and anti-neoplastic properties. considered phytoestrogen. As such, genistein can bind estrogen receptors (ERα ERβ), although with lower affinity than that of estradiol. Despite considerable work, the effects are not well established yet. This review aims clarify role on female male reproductive functions in mammals. In females, at high dose, diminishes ovarian activity regulating several pathway molecules, such as topoisomerase isoform I II, protein tyrosine kinases (v-src, Mek-4, ABL, PKC, Syk, EGFR, FGFR), ABC, CFTR, Glut1, Glut4, 5α-reductase, PPAR-γ, mitogen-activated kinase A, histidine kinase, recently circulating RNA-miRNA. The effect pregnancy still controversial. males, exerts an estrogenic by inducing testosterone biosynthesis. interaction both synthetic endocrine disruptors has negative testis function. positive sperm quality debate. conclusion, potentially beneficial mechanisms reproduction females males. However, this dependent species, route, time administration.

Language: Английский

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Effect of Goji Berry (Lycium barbarum) Supplementation on Reproductive Performance of Rabbit Does

Animals, Journal Year: 2021, Volume and Issue: 11(6), P. 1672 - 1672

Published: June 3, 2021

Goji berry shows a wide range of beneficial properties in human health, but only few studies evaluated its effects livestock animals. The objective this research was to assess the goji supplementation on hormonal profile, productive, and reproductive performance does. Two months before artificial insemination, 105 nulliparous does were randomly divided into three groups (n = 35) based dietary treatment: commercial diet (C), or supplemented with either 1% (G1), 3% (G3) berry, respectively. results showed that receptivity higher G1 than C group (p < 0.05). Trends toward significance for differences between G3 marginal means LH concentrations 0.059), AUC values 0.078), evidenced. Estrogen more fluctuating trend significant interaction effect 0.001). litter weight at birth 0.008) weaning 0.001), as well size 0.020). also exhibited highest mean milk production 0.01). In conclusion, influenced productive performance, probably via modulating patterns rabbits. However, further are needed validate these preliminary results.

Language: Английский

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Ovarian activity, hormone profile, pro‐inflammatory cytokines and reproductive performance of buffalo cows fed diets with different estrogenicity

Journal of Animal Physiology and Animal Nutrition, Journal Year: 2023, Volume and Issue: 108(1), P. 1 - 12

Published: June 28, 2023

Abstract Buffalo cows play a vital role in milk and meat production; however, they are characterised by several reproductive disorders. Feeding diets with high oestrogenic activity may be disrupting factor. This study aimed to evaluate the effects of feeding roughages different on performance early postpartum buffalo cows. A total 30 were equally stratified into two experimental groups fed either Trifolium alexandrinum (Berseem clover, phytoestrogenic roughage) or corn silage (nonoestrogenic for 90 consecutive days. After 35 days from beginning treatments, both synchronized oestrus using double i.m. injection 2 mL prostaglandin F 2α , 11 apart, subsequently, overt signs observed recorded. Moreover, ovarian structures, numbers sizes follicles corpora lutea, ultrasonography examined at day—12 (represents Day treatment), 0 (day oestrus) after oestrous synchronization (mid‐luteal phase). Pregnancy was diagnosed postinsemination. Blood serum samples analysed progesterone (P 4 ), estradiol (E tumor necrosis factor (TNF‐α), interlukein‐1β (IL‐1β) nitric oxide (NO). The liquid chromatography‐analysis showed abundance isoflavones Berseem about 58 times higher concentration than that group. During period, all size categories clover group No significant difference lutea between groups, but lower ( p < 0.05) diameter corpus luteum had overall concentrations blood E IL‐1β TNF‐α, P those recorded Oestrous rate, onset time duration not significantly affected treatment. conception rate reduced compared In conclusion, roughage such as can negatively affect loss seems associated inadequate luteal function during pregnancy.

Language: Английский

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Effect of Dried Apple Pomace (DAP) as a Feed Additive on Antioxidant System in the Rumen Fluid

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(18), P. 10475 - 10475

Published: Sept. 9, 2022

The study aimed to evaluate the effect of dried apple pomace (DAP) as a feed additive on enzymatic activity and non-enzymatic compounds belonging antioxidant system in cattle rumen fluid. experiment included 4 Polish Holstein−Friesian cannulated dairy cows lasted 52 days. control group was fed with standard diet, while experimental group, 6% feedstuff replaced by pomace. After feeding period, ruminal fluid collected. spectrophotometric technique for lysosomal enzymes, content vitamin C, polyphenols, potential scavenge free DPPH radical used. enzyme immunoassay tests (ELISA) were used establish antioxidants enzymes MDA. Among aminopeptidases, significant reduction (p < 0.01) from 164.00 142.00 observed leucyl-aminopeptidase. glycosidases decreased HEX (from 231.00 194.00) β-Glu 1294.00 1136.00), statistically increase noticed BGRD 31.10 42.40), α-Glu 245.00 327.00), MAN 29.70 36.70). Furthermore, catalase GSH inhibited. In turn, level C 22.90 24.10) MDA 0.36 0.45) higher 0.01). most positive correlations between AlaAP LeuAP (r = 0.897) aminopeptidases β-Gal 0.880) group. one perceived SOD 0.505) AcP 0.450). negative correlation α-Gal −0.533) based these observations. Apple has an influence degradation processes modifies oxidation−reduction Polyphenols other low-weight are sufficient maintain redox balance rumen.

Language: Английский

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Partitioning of nutritional and phytochemical constituents in nine Adzuki bean genotypes from Australia

Journal of Agriculture and Food Research, Journal Year: 2022, Volume and Issue: 10, P. 100398 - 100398

Published: Sept. 17, 2022

With an increasing demand for the efficient use of farmland resources, there is growing interest in value-adding to crops through using them or their by-products various food processing industries. Adzuki bean one emerging crop which shows promise chain; however, limited information on phytochemical contents parts this plant when grown under Australian conditions. Consequently, study investigated within-plant partitioning nutritional and constituents nine newly developed adzuki genotypes from Australia. The took about 80–85 days reach maturity showed moderate high protein gross energy both seed (20–25%, 16–17 MJ/kg) leaf (19–24% 16–18 material. leaves also levels phenolics antioxidants, may be linked improved health growth rates if fed livestock. Additionally, seedcoat contained exceptionally concentrations antioxidant compounds, indicating potential benefits humans. However, was a significant difference level health-benefitting compounds between different genotypes. These results support prospect as future high-value Central Queensland region.

Language: Английский

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