Journal of Research in Pharmacy,
Journal Year:
2024,
Volume and Issue:
28(1)(28(1)), P. 177 - 190
Published: Jan. 1, 2024
Acne
is
an
inflammatory
or
non-inflammatory
disease
that
can
be
seen
at
every
stage
of
human
life
and
affects
daily
both
physically
psychologically.In
the
topical
treatment
acne,
substances
with
different
pharmacological
effects
such
as
benzoyl
peroxide,
isotretinoin,
azelaic
acid
(AZE),
erythromycin
are
used
alone
in
combination.AZE
cream
(20%)
has
been
frequently
preferred
mild
moderate
acne
recent
years.However,
since
AZE
poor
solubility
water,
its
low
permeability
problems
may
occur.In
this
study,
soluble
form
was
obtained
by
forming
inclusion
complex
2-hydroxypropyl
β-cyclodextrin
(HβC).In
addition,
gel
formulation,
which
generally
exhibits
higher
properties
than
oily
formulations,
prepared
using
hydroxypropyl
methylcellulose
(HPMC).The
formation
confirmed
NMR,
XRD,
DSC,
FTIR
analyses.As
a
result
characterization
studies
hydrogel
it
determined
they
had
pseudoplastic
flow
their
viscosity
approximately
220
Pa.s.In
drug
release
conducted
dialysis
bag
method,
found
AZE-HβC
formulations
similar
cumulative
percent
HβC-free
hydrogels
but
showed
commercial
(Azelderm,
Orva,
Türkiye).It
proven
exhibit
profile
accordance
Higuchi
kinetics
from
Azelderm
according
to
difference
(f1)
similarity
(f2)
factors.
To
improve
efficacy
and
safety
of
sunscreen
emulsions,
UV‐filter
skin
permeation
could
be
kept
as
low
possible
by
reducing
content
or
changing
emulsion
composition.
In
this
work,
different
lipid
phase
ratio
(12,
14
16%
w/w)
were
assessed
for
their
ability
to
affect
the
technological
sensory
properties
O/W
emulsions
in
which
bemotrizinol
(BMTZ),
a
broad
spectrum
agent,
was
incorporated
free
loaded
into
nanostructured
nanocarriers
(NLC)
reduce
its
release
from
vehicle
and,
hence,
permeation.
The
following
evaluated
vitro
suitable
methodologies:
spreadability,
viscosity,
pH,
occlusion
factor,
BMTZ
release,
sun
protection
factor
(SPF).
Sensory
attributes
trained
panelists
three
phases:
before/during
pick‐up,
rub‐in,
after
application.
Raising
led
an
increase
viscosity
corresponding
drop
spreadability
while
incorporation
BMTZ‐loaded
NLC
determined
decrease
SPF.
No
observed
all
emulsions.
mainly
affected
ratio.
These
results
suggest
that
contribute
determine
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(7), P. 898 - 898
Published: July 4, 2024
The
article
aimed
to
formulate
an
MLX
binary
ethosome
hydrogel
for
topical
delivery
escalate
solubility,
facilitate
dermal
permeation,
avoid
systemic
adverse
events,
and
compare
the
permeation
flux
efficacy
with
classical
type.
ethosomes
were
prepared
using
hot
method
according
Box-Behnken
experimental
design.
formulation
was
implemented
16
design
formulas
four
center
points.
Independent
variables
(soya
lecithin,
ethanol,
propylene
glycol
concentrations)
dependent
(vesicle
size,
dispersity
index,
encapsulation
efficiency,
zeta
potential).
suggested
optimized
formula
(MLX-Ethos-OF)
highest
desirability
perform
best
responses
formulated
validated.
It
demonstrates
a
169
nm
vesicle
0.2
83.1
EE%,
-42.76
mV
good
potential.
MLX-Ethos-OF
shows
amorphous
form
in
PXRD
high
vitro
drug
release
of
>90%
over
7
h
by
diffusion
erosion
mechanism.
hyaluronic
acid
fabricated
assessed.
elegant
physical
appearance,
shear
thinning
system
rheological
behavior,
spreadability,
skin-applicable
pH
value.
ex
vivo
profile
rate
70.45
μg/cm
Cosmetics,
Journal Year:
2024,
Volume and Issue:
11(4), P. 123 - 123
Published: July 19, 2024
Different
lipid
phase
ratios
(12,
14,
and
16%
w/w)
were
assessed
for
their
ability
to
affect
the
technological
sensory
properties
of
O/W
emulsions
in
which
bemotrizinol
(BMTZ),
a
broad-spectrum
sunscreen
agent,
was
incorporated
free
or
loaded
into
nanostructured
nanocarriers
(NLC)
reduce
its
release
from
vehicle
and,
hence,
skin
permeation.
The
following
evaluated
vitro:
spreadability,
viscosity,
pH,
occlusion
factor,
BMTZ
release,
sun
protection
factor
(SPF).
Sensory
attributes
by
panelists
three
different
phases:
before/during
pick-up,
rub-in,
after
application.
Raising
ratio
led
an
increase
viscosity
(from
8017
±
143
cPs
16,444
770
cPs)
corresponding
decrease
spreadability
9.35
0.21
cm
7.50
0.10
cm),
while
incorporation
BMTZ-loaded
NLC
determined
47.75
1.16
25.91
1.57)
SPF
6%
formulations
containing
12%
15%
phase).
No
observed
all
emulsions.
mainly
affected
ratio.
These
results
suggest
that
could
contribute
determining
Saudi Pharmaceutical Journal,
Journal Year:
2024,
Volume and Issue:
32(9), P. 102152 - 102152
Published: July 28, 2024
Skin
infections
considered
as
one
of
the
predominant
disorders
that
could
greatly
influence
humans.
Topical
drug
delivery
is
believed
to
be
an
effective
substitute
systemically
delivered
medication
for
skin
management.
Erythromycin
has
been
proven
retain
anti-bacterial
activity.
Based
on
that,
aim
existent
study
develop
a
proper
nanocarrier,
namely;
nanoemulsion
using
tea
tree
oil
including
Erythromycin.
Applying
quality
by
design
approach,
optimized
was
selected
based
number
independent
variables
particle
size
and
Science & Technology Indonesia,
Journal Year:
2024,
Volume and Issue:
9(2), P. 380 - 412
Published: April 2, 2024
Quercetin
is
a
highly
prevalent
flavonoid
commonly
found
in
wide
variety
of
fruits
and
vegetables.
This
compound
has
various
biological
actions,
indicating
great
potential
preventing
diseases
promoting
health
but
the
disadvantages
include
low
solubility
instability.
The
can
be
overcome
by
using
polymer
composite
form
microspheres
formulation.
Therefore,
this
study
aimed
to
review
uses
polymers
delivering
quercetin
compounds.
results
showed
that
have
been
formulated
with
minimize
weaknesses.
delivery
systems
developed
reported
from
several
related
studies
microencapsulation,
microcapsules,
microparticles,
microspheres,
solid
lipid
microparticles
(SLM),
nanoparticles.
Polymers
including
Gelatine,
Maltodextrin
Inulin,
Carnauba
wax,
Poly
(lactic-co-glycolic
acid
(PLGA),
Gyceryl
behenate,
Pectin,
Nano-hydroxyapatite,
Polycaprolactone,
Starch,
Chitosan,
Eudragit
S
100,
Sodium
Alginate,
Ethyl
cellulose,
Alumina
efficiently
improved
properties
quercetin,
enabling
utilization
as
controlled
drug
agent.
developing
system
presents
both
an
opportunity
challenge
for
future
applications.
