Preparation, Characterization, and Biological Assessment of Heterocyclic Schiff Base Metal Complexes DOI Open Access

Y. Prashanthi,

K. Kiranmai,

Tentu Nageswara Rao

et al.

Advances in Research, Journal Year: 2024, Volume and Issue: 25(4), P. 47 - 56

Published: May 8, 2024

MIIMC, MMIIMC, and CMIIMC are biologically significant Schiff bases formed by the condensation of 3-amino-5-methyl isoxazole with formyl chromone. Substituted chromones metal chelates containing Cu(II), Ni(II), Co(II), Zn(II) prepared. These were studied utilising elemental analysis, FTIR, UV-VIS, 1H, 13C, mass spectra, magnetic susceptibility, conductance tests, thermogravimetric techniques. The data revealed that ligands display neutral, bidentate coordination through carbonyl oxygen azomethine nitrogen. antibacterial activity complexes is determined in vitro against bacteria fungus using paper disc method. Metal have significantly higher MIC values than ligands. DNA binding properties Cu(II) examined. MTT used to determine complexes' anticancer efficacy HL60 tumour cells. researchers discovered prevented apparent morphological alterations. inhibition ratio was hastened increasing dosage, it had a strong positive association medicine dosage. Thermal analysis showed initial loss due moisture hydrated water molecules, followed weight at 220oC coordinated indicating oxide breakdown.

Language: Английский

Mechanism of β–cyclodextrin - thyme nanocomplex formation and release: In silico behavior, structural and functional properties DOI Creative Commons
Andreea Lanciu Dorofte, Cristian Dima, Iulia Bleoancă

et al.

Carbohydrate Polymer Technologies and Applications, Journal Year: 2024, Volume and Issue: 7, P. 100422 - 100422

Published: Jan. 4, 2024

Nanoencapsulation of thyme essential oil (TEO) volatiles into β-cyclodextrin (β-CD) and their release requires in-depth kinetic, structural in silico studies for elucidating the mechanisms attaining equilibrium state. Monoclinic crystalline structures β-CD/TEO with 5 –10 μm were formed by TEO encapsulation visualized using SEM. The β-CD:TEO 8.5:1.5 (w/w) ratio ensures 71.66% retention efficiency a cumulative hexane after 7 h 75%. Thymol molecule is favourite candidate to occupy inner cavity β-CD, although competition carvacrol, o-cymene, 2-carene camphene against thymol was noticed GC/MS when increasing concentration. molecular mechanics calculations suggested that binding thymol, carvacrol o- cymene within hydrophobic β-CD thermodynamically achievable, having complexation energy between -18.48 ÷ -22.07 kcal/mol, nonetheless most stable complex α- pinene, if input provided, displaying lowest energy, -25.89 kcal/mol. All inclusion (IC) powders had similar antiradical activity DPPH (40 - 43%). IC2 8.5:3.00 powder displayed antibacterial Bacillus cereus, while IC3 8.5:1.50 exhibited strongest antifungal all Geotrichum candidum Rhodotorula glutinis. ICs obtained suggest competitive mechanism components occupying predispose each formulae specific applications food relation functional properties.

Language: Английский

Citations

4
Investigating the potential of Schinus moll e leaf essential oil for weed management, antibacterial applications, and enzymatic inhibition DOI
Sana Khedhri,

Flavio Polito,

Lucia Caputo

et al.

Journal of Essential Oil Bearing Plants, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 13

Published: Feb. 12, 2025

Language: Английский

Citations

0
Synthesis, Crystal Structure and Spectral Characterization of 5-Methyl-2-(Propan-2-yl)Cyclohexyl Cyanoacetate and 1,3,3-Trimethylbicyclo[2.2.1]Heptan-2-yl Cyanoacetate DOI

Fatma Mohamed,

Julia Bąkowicz, Błażej Dziuk

et al.

Journal of Structural Chemistry, Journal Year: 2025, Volume and Issue: 66(2), P. 399 - 406

Published: Feb. 1, 2025

Language: Английский

Citations

0
Terpene and Nanotechnology DOI
Monika Maheshwari

IGI Global eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 141 - 174

Published: March 7, 2025

The amalgamation of terpene chemistry and nanotechnology represents a captivating frontier in the realm drug delivery, offering plethora opportunities for precision medicine enhanced therapeutic outcomes. Terpenes, abundant nature revered their diverse pharmacological properties, hold immense potential augmenting delivery strategies. Concurrently, empowers researchers with precise control over formulation paving way targeted therapeutics improved efficacy reduced side effects. This chapter embarks on comprehensive journey to unravel synergistic interplay between terpenes nanotechnology, elucidating key principles, recent advancements, promising examples terpene-based nanocarriers applications.

Language: Английский

Citations

0
Natural plant-derived terpenes: antioxidant activity and antibacterial properties against foodborne pathogens, food spoilage and lactic acid bacteria DOI Creative Commons
Angela Di Matteo, Margherita Lavorgna, Chiara Russo

et al.

Applied Food Research, Journal Year: 2024, Volume and Issue: unknown, P. 100528 - 100528

Published: Sept. 1, 2024

Language: Английский

Citations

3
Phytochemicals from edible flowers prevent neurodegenerative diseases via the gut-brain axis DOI
Fatemeh Abbaszadeh, Sajad Fakhri, Behrang Shiri Varnamkhasti

et al.

Food Bioscience, Journal Year: 2024, Volume and Issue: unknown, P. 105681 - 105681

Published: Dec. 1, 2024

Language: Английский

Citations

1
Exploring the Antimicrobial Potential of Spirogyra neglecta against MastitisInducing Pathogens DOI Open Access
Yuwadee Insumran,

Jackaphan Sriwongsa,

Kraijak Kaewprom

et al.

International Journal of Veterinary Science, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Mastitis is an inflammation of the mammary gland that significantly threatens dairy productivity.With emergence antibiotic-resistant pathogens, it has become necessary to find alternative antimicrobial agents.Spirogyra neglecta, a filamentous green alga, known for its diverse bioactive compounds.This study uses various solvents investigate potential S. neglecta extracts against mastitis-inducing pathogens.The results show methanol extract highest efficacy in inhibiting bacterial growth, with minimum inhibitory concentration (MIC) values ranging from 8.75-200mg/mL.These findings highlight promising capabilities and as natural agent combatting pathogens.This research paves way further exploration utilization veterinary pharmaceutical applications.

Language: Английский

Citations

0
Preparation, Characterization, and Biological Assessment of Heterocyclic Schiff Base Metal Complexes DOI Open Access

Y. Prashanthi,

K. Kiranmai,

Tentu Nageswara Rao

et al.

Advances in Research, Journal Year: 2024, Volume and Issue: 25(4), P. 47 - 56

Published: May 8, 2024

MIIMC, MMIIMC, and CMIIMC are biologically significant Schiff bases formed by the condensation of 3-amino-5-methyl isoxazole with formyl chromone. Substituted chromones metal chelates containing Cu(II), Ni(II), Co(II), Zn(II) prepared. These were studied utilising elemental analysis, FTIR, UV-VIS, 1H, 13C, mass spectra, magnetic susceptibility, conductance tests, thermogravimetric techniques. The data revealed that ligands display neutral, bidentate coordination through carbonyl oxygen azomethine nitrogen. antibacterial activity complexes is determined in vitro against bacteria fungus using paper disc method. Metal have significantly higher MIC values than ligands. DNA binding properties Cu(II) examined. MTT used to determine complexes' anticancer efficacy HL60 tumour cells. researchers discovered prevented apparent morphological alterations. inhibition ratio was hastened increasing dosage, it had a strong positive association medicine dosage. Thermal analysis showed initial loss due moisture hydrated water molecules, followed weight at 220oC coordinated indicating oxide breakdown.

Language: Английский

Citations

0