Chitooligosaccharides suppress airway inflammation, fibrosis, and mucus hypersecretion in a house dust mite-induced allergy model

Frontiers in Allergy, Journal Year: 2025, Volume and Issue: 6

Published: Jan. 23, 2025

Background Respiratory allergy is a serious respiratory disorder characterized by inflammation, mucus hypersecretion, and airway tissue sclerosis. Disruption of the T helper 1 (Th1) 2 (Th2) immune systems stimuli induced house dust mites (HDM) fine particulate matter leads to secretion various inflammatory cytokines, resulting in diseases inflammation. Chitooligosaccharides (COS) are known for their antioxidant anti-inflammatory properties. Methods Human epithelial cells (BEAS-2B) were cultured DMEM/F12 medium containing COS at concentrations 25–100 µg/ml 24 h. No intracellular toxicity was observed up 1,000 µg/ml. Cell experiments conducted below 100 µg/ml, while animal performed mg/kg body weight 4 weeks. Samples right lung obtained from experimental animals used gene protein expression analysis, whereas samples contralateral immunohistochemical analysis. Results regulated Th1 immunity inhibiting major including tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6), BEAS-2B cells. In HDM-induced allergic model, suppressed infiltration around airways inhibited mRNA cytokines tissues, also reducing nuclear factor kappa B (NF-κB)-related proteins. Furthermore, results confirmed suppression levels immunoglobulin E (IgE) blood secreted mast activated HDM, which led reduction hypersecretion Conclusion summary, thought improve resistance alleviating caused HDM regarded as substances that regulate balance Th2 affected hypersecretion.

Language: Английский

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Chitosan-based pulmonary particulate systems for anticancer and antiviral drug carriers: A promising delivery for COVID-19 vaccines

Results in Chemistry, Journal Year: 2023, Volume and Issue: 6, P. 101146 - 101146

Published: Oct. 4, 2023

Chitosan (CHI) has anti-microbial and anti-cancer characteristics in addition to being biodegradable biocompatible as a polymer. It recently attracted lot of attention potential drug carrier framework material for pulmonary therapeutic transport, particularly the context treating infectious diseases cancer. CHI mucoadhesive, permeation-enhancing, site- cell-specific properties all play key role carrier's efficacy circulation. Numerous microencapsulation micro-nanomixing techniques have been developed provide nanocarriers with proper aerodynamic profile effective aerosolization inhalation. Acute respiratory distress syndrome (ARDS) cancer are outcomes subsequent infection COVID-19. The effectiveness anti-CoV treatments using its derivatives varies molecular weight, substituent type, degree substitution. From viewpoint delivery (DD), performance, is anticipated attract more throughout coming decade.

Language: Английский

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Strategies to Prepare Chitin and Chitosan-Based Bioactive Structures Aided by Deep Eutectic Solvents: A Review

Catalysts, Journal Year: 2024, Volume and Issue: 14(6), P. 371 - 371

Published: June 10, 2024

Chitin and chitosan, abundant biopolymers derived from the shells of crustaceans cell walls fungi, have garnered considerable attention in pharmaceutical circles due to their biocompatibility, biodegradability, versatile properties. Deep eutectic solvents (DESs), emerging green composed mixtures hydrogen bond acceptors donors, offer promising avenues for enhancing solubility functionality chitin chitosan formulations. This review delves into potential utilizing DESs as highlighting efficiency dissolving these polymers, which facilitates production novel drug delivery systems, wound dressings, tissue engineering scaffolds, antimicrobial agents. The distinctive physicochemical properties DESs, including low toxicity, volatility, adaptable solvation power, enable customization chitosan-based materials meet specific requirements. Moreover, environmentally friendly nature aligns with growing demand sustainable eco-friendly processes manufacturing. revision underscores recent advances illustrating role evolving applications laying groundwork development innovative systems biomedical enhanced efficacy safety profiles.

Language: Английский

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From Bin to Benefit: Sustainable Valorization of Grapefruit (Citrus paradisi) Byproducts Towards the Circular Economy

Current Food Science and Technology Reports, Journal Year: 2024, Volume and Issue: 2(3), P. 271 - 296

Published: May 17, 2024

Language: Английский

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Chitosan nanoparticles in vaccine delivery systems

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 309 - 362

Published: Nov. 29, 2024

Language: Английский

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