Colon Cancer: Overview on Improved Therapeutic Potential of Plant-Based Compounds Using Nanotechnology DOI Creative Commons
Manuel López-Cabanillas Lomelí, A. Sáenz, David Gilberto García‐Hernandez

et al.

Scientia Pharmaceutica, Journal Year: 2024, Volume and Issue: 93(1), P. 1 - 1

Published: Dec. 24, 2024

Colon cancer (CC) is the third most frequent neoplasm, with a considerably high mortality rate. Due to side effects of conventional forms CC treatment (surgery, chemotherapy, and radiotherapy), several studies have focused on use medicinal plant derivatives provide green therapy for CC; although phytochemicals shown promising results against CC, translating obtained in vitro vivo clinical setting remains challenge. Indeed, like other orally applied medicines, cross different physiological barriers reach microenvironment, which limits their dose-dependent therapeutic efficacy. On hand, phytocompounds are not free from biopharmaceutical drawbacks, so novel strategies using nanoparticles (NPs) been proposed overcome body controlled release actives interest. Accordingly, current review provides an overview discussion predisposing factors treatment, plants advantages provided by NPs CC.

Language: Английский

Advancements in Colorectal Cancer Treatment: The Role of Metal-Based and Inorganic Nanoparticles in Modern Therapeutic Approaches DOI
Maryam Azarian, Marzieh Ramezani Farani, William C. Cho

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 264, P. 155706 - 155706

Published: Nov. 6, 2024

Language: Английский

Citations

9
Cutting-edge nanotechnology: unveiling the role of zinc oxide nanoparticles in combating deadly gastrointestinal tumors DOI Creative Commons

Yonggang Guo,

Mohammadamin Morshedi

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: March 20, 2025

Zinc oxide nanoparticles (ZnO-NPs) have gained significant attention in cancer therapy due to their unique physical and chemical properties, particularly treating gastrointestinal (GI) cancers such as gastric, colorectal, hepatocellular carcinoma. These generate reactive oxygen species (ROS) upon entering cells, causing oxidative stress that leads cellular damage, DNA fragmentation, apoptosis. ZnO-NPs affect the expression of key proteins involved apoptosis, including p53, Bax, Bcl-2, which regulate cell cycle arrest programmed death. Additionally, can reduce mitochondrial membrane potential, further enhancing apoptosis cells. Furthermore, inhibit proliferation by interfering with progression. They levels cyclins cyclin-dependent kinases (CDKs), leading arrest. also exhibit anti-metastatic properties inhibiting migration invasion cells through modulation signaling pathways adhesion cytoskeletal dynamics. The efficacy overcoming chemotherapy resistance has been demonstrated ability IC50 values chemotherapeutic agents, making more susceptible drug-induced In this review, we summarize mechanisms exert anticancer effects GI cancers, focusing on regulation, metastasis inhibition, while highlighting current limitations translating these findings into effective clinical treatments.

Language: Английский

Citations

0
Colon Cancer: Overview on Improved Therapeutic Potential of Plant-Based Compounds Using Nanotechnology DOI Creative Commons
Manuel López-Cabanillas Lomelí, A. Sáenz, David Gilberto García‐Hernandez

et al.

Scientia Pharmaceutica, Journal Year: 2024, Volume and Issue: 93(1), P. 1 - 1

Published: Dec. 24, 2024

Colon cancer (CC) is the third most frequent neoplasm, with a considerably high mortality rate. Due to side effects of conventional forms CC treatment (surgery, chemotherapy, and radiotherapy), several studies have focused on use medicinal plant derivatives provide green therapy for CC; although phytochemicals shown promising results against CC, translating obtained in vitro vivo clinical setting remains challenge. Indeed, like other orally applied medicines, cross different physiological barriers reach microenvironment, which limits their dose-dependent therapeutic efficacy. On hand, phytocompounds are not free from biopharmaceutical drawbacks, so novel strategies using nanoparticles (NPs) been proposed overcome body controlled release actives interest. Accordingly, current review provides an overview discussion predisposing factors treatment, plants advantages provided by NPs CC.

Language: Английский

Citations

0