Cell adhesion on substrates with variable curvature: Effects on genetic transcription processes DOI Creative Commons

Óscar L. Rodríguez-Montaño,

Lorenzo Santoro, Lorenzo Vaiani

et al.

Computers in Biology and Medicine, Journal Year: 2025, Volume and Issue: 189, P. 109917 - 109917

Published: Feb. 28, 2025

Language: Английский

Lattice Models: Non-Conventional simulation methods for mechanobiology DOI
Lorenzo Vaiani, Antonio Emmanuele Uva, Antonio Boccaccio

et al.

Journal of Biomechanics, Journal Year: 2025, Volume and Issue: unknown, P. 112555 - 112555

Published: Jan. 1, 2025

Language: Английский

Citations

0
Micro‐Scale Topography Triggers Dynamic 3D Nuclear Deformations DOI Creative Commons
Claire Leclech, Giulia Cardillo,

Bettina Roellinger

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Navigating complex extracellular environments requires extensive deformation of cells and their nuclei. Most in vitro systems used to study nuclear deformations impose whole-cell confinement that mimics the physical crowding experienced by during 3D migration through tissues. Such systems, however, do not reproduce types expected occur line tissues such as endothelial or epithelial whose stems principally from topography underlying basement membrane. Here, it is shown myoblasts cultured on microgroove substrates mimic anisotropic membrane exhibit large-scale deformations, with partial complete penetration into microgrooves. These lead significant DNA damage are dynamic nuclei cyclically entering exiting Atomic force microscopy measurements show these cycles accompanied transient changes perinuclear stiffness. Interestingly, grooves driven cell-substrate adhesion stresses, a limited need for cytoskeleton-associated forces. Finally, demonstrated laminopathy patients abnormal microgrooves, raising possibility using novel functional diagnostic platform pathologies involve mechanics.

Language: Английский

Citations

0
Role of Cell Adhesion in Cancer Metastasis Formation: A Review DOI Creative Commons

Denis Burčík,

Ján Macko, Natalia Podrojková

et al.

ACS Omega, Journal Year: 2025, Volume and Issue: 10(6), P. 5193 - 5213

Published: Feb. 9, 2025

Intercellular adhesion is accompanied by several physical quantities and actions. In this review, we tried to collect information about the influence of surface energy its impact on cell-cell adhesion. It still undergoes development for cancer treatment. Data receptor-ligand interactions that occur circulating tumor cells (CTCs) are described, receptors as therapeutic targets collected. Additionally, roughness between CTC was monitored. The effects different cell molecules (CAMs) adhesion, growth, proliferation were investigated. This review offers general principles through blockade with blocking drugs inhibitors like computational models describe process Some theoretical based minimum total free interaction CAMs selected organic have been presented. final aim find how modulation CTCs (by medicals or physically) inhibits metastases formation.

Language: Английский

Citations

0
Cell adhesion on substrates with variable curvature: Effects on genetic transcription processes DOI Creative Commons

Óscar L. Rodríguez-Montaño,

Lorenzo Santoro, Lorenzo Vaiani

et al.

Computers in Biology and Medicine, Journal Year: 2025, Volume and Issue: 189, P. 109917 - 109917

Published: Feb. 28, 2025

Language: Английский

Citations

0