A Decade of Antimicrobial Resistance in Human and Animal Campylobacter spp. Isolates

Antibiotics, Journal Year: 2024, Volume and Issue: 13(9), P. 904 - 904

Published: Sept. 21, 2024

Objectives: Campylobacter spp. remain a leading cause of bacterial gastroenteritis worldwide, with resistance to antibiotics posing significant challenges treatment and public health. This study examines profiles in antimicrobial (AMR) for isolates from human animal sources over the past decade. Methods: We conducted comprehensive review data studies spanning ten years, analyzing key antibiotics, ciprofloxacin (CIP), tetracycline (TET), erythromycin (ERY), chloramphenicol (CHL), gentamicin (GEN). Data were collated various regions assess global regional patterns resistance. Results: The analysis reveals concerning trend increasing patterns, particularly CIP TET, across multiple regions. While CHL GEN remains relatively low, high prevalence has significantly compromised options campylobacteriosis. Discrepancies observed between isolates, variations different continents countries. Notably, ERY showed variability, reflecting potential differences usage management practices. Conclusions: findings underscore ongoing challenge AMR Campylobacter, highlighting need continued surveillance research. rising prevalence, coupled discrepancies emphasize importance One Health approach address AMR. Enhanced monitoring, novel strategies, cooperation are crucial mitigating impact ensuring effective Campylobacter-related infections.

Language: Английский

Microbiome Shifts and Their Impact on Gut Physiology in Irritable Bowel Syndrome

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12395 - 12395

Published: Nov. 19, 2024

Irritable bowel syndrome (IBS) is one of the most prevalent functional gastrointestinal disorders characterized by recurrent abdominal pain and altered habits. The exact pathophysiological mechanisms for IBS development are not completely understood. Several factors, including genetic predisposition, environmental psychological influences, low-grade inflammation, alterations in motility, dietary habits, have been implicated pathophysiology disorder. Additionally, emerging evidence highlights role gut microbiota IBS. This review aims to thoroughly investigate how impact physiological functions such as brain-gut axis, immune system activation, mucosal permeability, intestinal motility. Our research focuses on dynamic "microbiome shifts", emphasizing enrichment or depletion specific bacterial taxa their profound disease progression pathology. data indicated that populations IBS, reductions beneficial species

Language: Английский

Role of Gut Microbiota in Immune System Regulation

Pakistan Journal of Health Sciences, Journal Year: 2024, Volume and Issue: unknown, P. 02 - 12

Published: Aug. 31, 2024

The human gut is a densely populated organ system that bears hundreds of microbial species, including bacteria, viruses, and various protozoans. microbiome expresses enormous functional diversity based on community collection. However, this has remained unexplored for long time, but in the recent past researches have revealed its immense significance host metabolism immunity. Gut microbiota metabolize undigested substances release metabolites response to significant effect immune system. balance stability within body are achieved maintained through complex interaction between mucosal Upon loss control by system, dysbiosis occurs, modulation community, which leads different disorders, inflammatory bowel disease colorectal cancer. Moreover, also associated with autoimmune diseases such as rheumatoid arthritis, diabetes mellitus, multiple sclerosis. Despite intricate mechanism diseases, therapeutic strategies utilized treat chronic prebiotics treatment, personalized probiotics therapy, fecal transplantation, narrow-spectrum antibiotic treatment. This review discusses how association becomes dysregulated, outcomes form interventions cope it.

Language: Английский