The Development and Pre-Clinical Anti-Inflammatory Efficacy of a New Transdermal Ureasil–Polyether Hybrid Matrix Loaded with Flavonoid-Rich Annona muricata Leaf Extract DOI Creative Commons
Camila Beatriz Barros Araújo, José de Oliveira Alves-Júnior, Mariana Rillo Sato

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(8), P. 1097 - 1097

Published: Aug. 21, 2024

This study aimed to develop a novel ureasil–polyether transdermal hybrid matrix (U-PEO) loaded with Annona muricata concentrated extract (AMCE), which exhibits potent anti-inflammatory activity. The was obtained by maceration, method that allowed for the extraction of high concentration flavonoids (39.27 mg/g extract). In vivo tests demonstrated 10 mg/kg AMCE inhibited inflammation 6 h. physicochemical characterization U-PEO conducted via thermogravimetric analysis (TGA), while its surface recorded using atomic force microscopy (AFM). in vitro macroscopic swelling and release hydrophilic profile material percentage released. TGA results system exhibited physical compatibility due thermal stability U-PEO. Additionally, AFM revealed rough porous surface, particular emphasis on AMCE. resulted liberation 23.72% within 24 Finally, preclinical also capable effectively inhibiting h, duration comparable commercial formulation. permit advancement towards development system, thereby rendering application clinical studies feasible.

Language: Английский

Preparation of Bio-glass and Bio-ceramic Utilizing Sol-Gel Method and Fabrication of Bio-scaffolds for drug loading and releasing application DOI

Takvir Hossan Parhad,

Fataha Nur Robel, Newaz Mohammed Bahadur

et al.

Ceramics International, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

Citations

0
Synthesis and characterization of Ce-doped TiO2/Cu-doped Fe3O4 heterogeneous photocatalyst for antibacterial applications and visible-light photocatalytic degradation of methylene blue DOI

Eiman Aghababaei,

Mehdi Alizadeh, Abbas Bahrami

et al.

Ceramics International, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

Citations

0
The Development and Pre-Clinical Anti-Inflammatory Efficacy of a New Transdermal Ureasil–Polyether Hybrid Matrix Loaded with Flavonoid-Rich Annona muricata Leaf Extract DOI Creative Commons
Camila Beatriz Barros Araújo, José de Oliveira Alves-Júnior, Mariana Rillo Sato

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(8), P. 1097 - 1097

Published: Aug. 21, 2024

This study aimed to develop a novel ureasil–polyether transdermal hybrid matrix (U-PEO) loaded with Annona muricata concentrated extract (AMCE), which exhibits potent anti-inflammatory activity. The was obtained by maceration, method that allowed for the extraction of high concentration flavonoids (39.27 mg/g extract). In vivo tests demonstrated 10 mg/kg AMCE inhibited inflammation 6 h. physicochemical characterization U-PEO conducted via thermogravimetric analysis (TGA), while its surface recorded using atomic force microscopy (AFM). in vitro macroscopic swelling and release hydrophilic profile material percentage released. TGA results system exhibited physical compatibility due thermal stability U-PEO. Additionally, AFM revealed rough porous surface, particular emphasis on AMCE. resulted liberation 23.72% within 24 Finally, preclinical also capable effectively inhibiting h, duration comparable commercial formulation. permit advancement towards development system, thereby rendering application clinical studies feasible.

Language: Английский

Citations

1