Curcumin-Loaded Lipid Nanoparticles: A Promising Antimicrobial Strategy Against Enterococcus faecalis in Endodontic Infections

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(1), P. 108 - 108

Published: Jan. 14, 2025

Background/Objectives: This study aims to evaluate the efficacy of curcumin (CUR), a natural polyphenol with potent antimicrobial and anti-inflammatory properties, when formulated as solid lipid nanoparticles (CUR-loaded SLN) against Enterococcus faecalis. Methods: Solid (SLNs) were prepared carrier for CUR, which significantly improved its solubility. SLNs made cetyl palmitate Tween 80 obtained via hot ultrasonication method. The physicochemical properties CUR-loaded evaluated, including their size, stability, release profile. Antimicrobial testing was conducted both sessile planktonic E. faecalis populations. Cytotoxicity assessed on human gingival fibroblasts. Results: exhibited about 200 nm −25 mV surface potential, encapsulation CUR did not affect SLNs. CURs released from in controlled sustained manner over 100 h. remained stable at least two months stored 4 °C or 25 °C, making them suitable clinical use. Antioxidant activity confirmed through DPPH ABTS assays. Free reduced CFU counts by approximately 65% after 24 h exposure. However, this inhibitory effect diminished longer exposure times (48 72 h). studies showed dose- time-dependent effects, 2.5–10 µg/mL range, populations, good cytocompatibility fibroblasts up 2.5 μg/mL, suggesting low toxicity. Conclusions: demonstrate significant faecalis, along cytocompatibility, indicating potential an effective adjunct therapy endodontic treatments.

Language: Английский

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Addressing the silent killer: Nanotechnology for preventing oral bacteria-induced cardiovascular risks

Deleted Journal, Journal Year: 2025, Volume and Issue: 9(1)

Published: March 4, 2025

Tooth extraction, while essential for oral health, can contribute to systemic complications, particularly increasing cardiovascular risk due bacterial translocation and inflammation. Periodontal disease, a major cause of tooth loss, exacerbates this by serving as reservoir pathogenic bacteria that enter the bloodstream during extractions. This review explores mechanisms linking post-extraction infections diseases evaluates role nanotechnology in mitigating these risks. Advances antimicrobial nanoparticles, nanodrug delivery systems, biosensors offer promising solutions infection control targeted drug delivery. These innovations enhance healing potentially reducing However, challenges remain optimizing material biocompatibility, ensuring clinical efficacy, addressing translational hurdles. underscores need interdisciplinary research integrate into dental practice, ultimately improving both health outcomes.

Language: Английский

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Antimicrobial Activity of Gels Supplemented With Nanoparticles as Intracanal Medication in Endodontics: A Systematic Review and Meta‐Analysis of In Vitro, In Vivo, and RCT Studies

Journal of Nanotechnology, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Background: The compalete eradication of microorganisms within the root canal system remains a challenge in endodontic treatment. Gels supplemented with nanoparticles, particularly silver nanoparticles (AgNPs), have shown promise enhancing antimicrobial efficacy. This systematic review and meta‐analysis aimed to evaluate activity these nanoparticle‐supplemented gels as intracanal medication endodontics. Methods: A comprehensive search was conducted PubMed, Web Science, SCOPUS databases up September 2024 using specific keywords related gels, Only studies published English were included. In vitro, vivo, randomized clinical trials (RCTs) comparing nanoparticle conventional agents selected based on predefined inclusion exclusion criteria. Data extraction risk bias assessment performed by independent reviewers. random‐effects model employed for estimate overall effectiveness gels. Heterogeneity among evaluated I 2 statistic. Results: Out 991 identified records, 752 screened after duplicate removal, 24 articles underwent full‐text review. Six met eligibility criteria included final analysis, comprising three vitro studies, one vivo study, RCTs. revealed that exhibited statistically significant positive effect (pooled size: 5.96; 95% CI: [0.92, 10.99]). However, high heterogeneity ( = 96%) observed. contrast, RCTs indicated no (combined effect: 1.04; [−0.06, 2.15]; 76%). Funnel plot asymmetry suggested potential publication bias. Conclusions: show efficacy but evidence from is inconsistent. High indicate need more standardized research accurately assess

Language: Английский

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Reviewing Additive Manufacturing Techniques: Material Trends and Weight Optimization Possibilities Through Innovative Printing Patterns

Materials, Journal Year: 2025, Volume and Issue: 18(6), P. 1377 - 1377

Published: March 20, 2025

Additive manufacturing is transforming modern industries by enabling the production of lightweight, complex structures while minimizing material waste and energy consumption. This review explores its evolution, covering historical developments, key technologies, emerging trends. It highlights advancements in innovations, including metals, polymers, composites, ceramics, tailored to enhance mechanical properties expand functional applications. Special emphasis given bioinspired designs their contribution enhancing structural efficiency. Additionally, potential these techniques for sustainable industrial scalability discussed. The findings contribute a broader understanding Manufacturing’s impact on design optimization performance, offering insights into future research

Language: Английский

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Bioceramics in Endodontics: Limitations and Future Innovations—A Review

Dentistry Journal, Journal Year: 2025, Volume and Issue: 13(4), P. 157 - 157

Published: April 1, 2025

Bioceramic materials for endodontic treatments have gradually transformed over the years into with enhanced biocompatibility and chemical mechanical properties compared to earlier generations. In endodontics procedures, these are used as restorative material in applications such root-end fillings, pulp capping, perforations repair, apexification repair procedures. However, they far from ideal handling properties, issues, aesthetic concerns due tooth discolouration, limited antibacterial activity, affordability, which amongst several key limitations. Notably, bioceramic popular their biocompatibility, sealing ability, durability, consequently surpassing traditional gutta-percha zinc oxide–eugenol sealers. A lack of recent advancements field, combined nanomaterials, has improved formulations overcome The existing literature emphasises benefits bioceramics while underreporting poor difficulties, cost, various other drawbacks. gaps identified insufficient coverage emerging materials, narrow scope, insights future developments, failures complications materials. Consequently, this review aims highlight limitations primarily focusing on calcium silicate, phosphate, bioactive glass-based most abundantly dentistry. Based literature, significantly years, different combinations technology generations preserving many original some having affordable costs. This also innovations that could shape highlighting ongoing evolution treatments.

Language: Английский

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Proliferation and differentiation of human dental pulp stem cells on phosphorylated cellulose nanofiber scaffolds

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: unknown, P. 123593 - 123593

Published: April 1, 2025

Human dental pulp stem cells (hDPSCs) are a promising cell source for tooth regeneration therapies. However, conventional culture scaffold materials often animal-derived, leading to immunogenicity concerns and limited availability. In this study, we explored phosphorylated cellulose nanofibers (P-CNFs), which have fine fiber morphology phosphate groups, as novel material culture. Immortalized hDPSCs were cultured on P-CNF scaffolds with different contents (0-1.42 mmol g-1) prepared by varying the molar ratio of urea diammonium hydrogen reaction time. Cells unmodified CNFs exhibited poor adhesion formed spheroids, indicating low bioadaptability. contrast, moderate content (0.54-0.78 significantly improved adhesion; further increases in decreased adhesion, strong dependence content. Intriguingly, even absence differentiation inducers, an optimal 0.78 g-1 showed equal or higher expression hard tissue marker genes compared collagen suggesting that P-CNFs can directly promote differentiation. These findings highlight plant-derived, animal-free biomaterial advanced engineering.

Language: Английский

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Nanoparticles in Endodontics

Published: April 28, 2025

Nanotechnology has emerged as a transformative innovation in endodontics, significantly enhancing the effectiveness of root canal treatments and promoting tissue regeneration. The application nanomaterials endodontic procedures offers improved disinfection, enhanced mechanical properties dental materials, potential for regenerative healing. Due to their small size large surface area, nanoparticles can deeply penetrate dentinal tubules, providing superior antimicrobial action reducing risk reinfection compared conventional methods. Nanomaterials also enhance strength, fracture resistance, adhesion sealers, thus increasing durability treatments. Moreover, nanotechnology shows promise pulp regeneration by facilitating targeted drug delivery supporting stem cell differentiation. Despite these advancements, challenges regarding safety, toxicity, long-term biocompatibility remain, necessitating ongoing research. This review explores current applications future highlighting its role improving therapy outcomes advancing care.

Language: Английский

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