Nano TransMed, Journal Year: 2024, Volume and Issue: unknown, P. 100069 - 100069
Published: Dec. 1, 2024
Language: Английский
Critical Reviews in Oncology/Hematology, Journal Year: 2025, Volume and Issue: unknown, P. 104653 - 104653
Published: Feb. 1, 2025
Language: Английский
Citations
3
Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 11
Published: Jan. 6, 2025
One of the most prevalent human infections is Helicobacter pylori (H. pylori), which affects more than half global population. Although H. are widespread, only a minority individuals develop severe gastroduodenal disorders. The resistance to antibiotics has reached concerning levels, significantly impacting effectiveness treatment. Consequently, development vaccines targeting virulence factors may present viable alternative for treatment and prevention infections. This review aims provide comprehensive overview current understanding infection, with particular focus on its factors, pathophysiology, vaccination strategies. discusses various associated pylori, such as cytotoxin-associated gene A (cagA), vacuolating cytotoxin (vacA), outer membrane proteins (OMPs), neutrophil-activated protein (NAP), urease (ure), catalase. based these characteristics essential controlling infection ensuring long-lasting protection. Various strategies formulations have been tested in animal models; however, their reproducibility humans remain uncertain. Different types vaccines, including vector-based inactivated whole cells, genetically modified protein-based subunits, multiepitope nucleic acid (DNA) explored. While some demonstrated promising results murine models, limited number successfully humans. article provides thorough evaluation recent research genes methods, offering valuable insights future address this health challenge.
Language: Английский
Citations
0
Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(2), P. 205 - 205
Published: Feb. 6, 2025
Cancer represents a significant societal, public health, and economic challenge. Conventional chemotherapy is based on systemic administration; however, it has current limitations, including poor bioavailability, high-dose requirements, adverse side effects, low therapeutic indices, the development of multiple drug resistance. These factors underscore need for innovative strategies to enhance delivery directly tumours. However, local treatment also presents challenges, penetration through endothelial layers, tissue density in tumour microenvironment, interstitial fluid pressure, physiological conditions within tumour, permanence at site action. Nanotechnology promising alternative addressing these challenges. This narrative review elucidates potential nanostructured formulations cancer treatment, providing illustrative examples an analysis advantages challenges associated with this approach. Among nanoformulations developed breast, bladder, colorectal, oral, melanoma cancer, polymeric nanoparticles, liposomes, lipid nanohydrogels have demonstrated particular efficacy. systems permit mucoadhesion enhanced penetration, thereby increasing concentration (bioavailability) consequently improving anti-tumour efficacy potentially reducing effects. In addition studies indicating chemotherapy, nanocarriers can be used as theranostic approach combination irradiation methods.
Language: Английский
Citations
0
Cancers, Journal Year: 2025, Volume and Issue: 17(5), P. 723 - 723
Published: Feb. 20, 2025
Background/Objectives: Tumour-associated macrophages (TAMs) are critical components of the tumour microenvironment (TME), significantly influencing cancer progression and treatment resistance. This review aims to explore innovative use engineered bacteria reprogram TAMs, enhancing their anti-tumour functions improving therapeutic outcomes. Methods: We conducted a systematic following predefined protocol. Multiple databases were searched identify relevant studies on phenotypic plasticity, for reprogramming. Inclusion exclusion criteria applied select studies, data extracted using standardised forms. Data synthesis was performed summarise findings, focusing mechanisms benefits non-pathogenic modify TAMs. Results: The summarises findings that can selectively target promoting shift from tumour-promoting M2 phenotype tumour-fighting M1 phenotype. reprogramming enhances pro-inflammatory responses activity within TME. Evidence various indicates significant regression improved immune bacterial therapy. Conclusions: Reprogramming TAMs presents promising strategy approach leverages natural targeting abilities directly tumour, potentially patient outcomes offering new insights into immune-based treatments. Further research is needed optimise these methods assess clinical applicability.
Language: Английский
Citations
0
Pathogens, Journal Year: 2025, Volume and Issue: 14(4), P. 355 - 355
Published: April 5, 2025
Antibiotic resistance represents a growing public health threat, with airborne drug-resistant strains being especially alarming due to their ease of transmission and association severe respiratory infections. The microbiome plays pivotal role in maintaining health, influencing the dynamics antibiotic among pathogenic microorganisms. In this context, review proposes exploration complex interplay between microbiota antimicrobial resistance, highlighting implications diversity disease. Moreover, strategies mitigate including stewardship programs, alternatives traditional antibiotics, probiotics, restoration techniques, nanotechnology-based therapeutic interventions, are critically presented, setting an updated framework current management options. Therefore, through better understanding roles alongside emerging strategies, paper aims shed light on how global challenges posed by multi-drug-resistant pathogens can be addressed.
Language: Английский
Citations
0
Next Nanotechnology, Journal Year: 2025, Volume and Issue: 8, P. 100159 - 100159
Published: Jan. 1, 2025
Language: Английский
Citations
0
Results in Surfaces and Interfaces, Journal Year: 2025, Volume and Issue: unknown, P. 100529 - 100529
Published: April 1, 2025
Language: Английский
Citations
0
Nano TransMed, Journal Year: 2024, Volume and Issue: unknown, P. 100069 - 100069
Published: Dec. 1, 2024
Language: Английский
Citations
2