Tackling Old Challenges in Microalgal Biotechnology: The Role of Photobioreactors to Advance the Technology Readiness Level DOI Open Access

Mariany Costa Deprá,

Rosângela Rodrigues Dias,

Leila Queiroz Zepka

et al.

Processes, Journal Year: 2024, Volume and Issue: 13(1), P. 51 - 51

Published: Dec. 29, 2024

Microalgae biotechnology has taken the world by storm. However, despite its great potential promise, it still cannot be considered a fully consolidated technology due to crucial challenge: low rates of biomass productivity. To overcome this hurdle, photobioreactors have been developed as an innovative solution, promising increase efficiency microalgae cultures providing optimized conditions. results obtained with these systems do not always meet initial expectations, and their large-scale implementation faces complex technical challenges. In light this, present review addresses main aspects related design engineering photobioreactors, highlighting potentialities limitations in overcoming critical challenges microalgal biotechnology. Furthermore, we discuss current technological readiness level commercial index microalgae-based bioproducts from perspective industrial-scale production.

Language: Английский

Bioengineering in Solid-State Fermentation for next sustainable food bioprocessing DOI Creative Commons
Muyideen Olaitan Bamidele, Micheal Bola Bamikale, Eliseo Cárdenas-Hernández

et al.

Next Sustainability, Journal Year: 2025, Volume and Issue: 6, P. 100105 - 100105

Published: Jan. 1, 2025

Language: Английский

Citations

6
Microbial functional diversity and redundancy: moving forward DOI Creative Commons
Pierre Ramond, Pierre E. Galand, Ramiro Logares

et al.

FEMS Microbiology Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Abstract Microbial functional ecology is expanding as we can now measure the traits of wild microbes that affect ecosystem functioning. Here, review techniques and advances could be bedrock for a unified framework to study microbial functions. These include our newfound access environmental genomes, collections traits, but also ability microbes’ distribution expression. We then explore technical, ecological, evolutionary processes explain patterns diversity redundancy. Next, suggest reconciling microbiology with biodiversity-ecosystem-functioning studies by experimentally testing significance redundancy efficiency, resistance, resilience processes. Such will aid in identifying state shifts tipping points microbiomes, enhancing understanding how where microbiomes guide Earth's biomes context changing planet.

Language: Английский

Citations

4
Physical stimuli-responsive 3D printable hydrogels for scalable manufacturing of bioengineered meat analogs DOI
Jieun Lee, Sayan Deb Dutta, Tejal V. Patil

et al.

Trends in Food Science & Technology, Journal Year: 2025, Volume and Issue: unknown, P. 104867 - 104867

Published: Jan. 1, 2025

Language: Английский

Citations

0
Innovations and challenges in collagen and gelatin production through precision fermentation DOI
Sofía Campos,

Gabriela dos Santos Costa,

Susan Grace Karp

et al.

World Journal of Microbiology and Biotechnology, Journal Year: 2025, Volume and Issue: 41(2)

Published: Feb. 1, 2025

Language: Английский

Citations

0
Advancements and challenges in microalgal protein production: A sustainable alternative to conventional protein sources DOI Creative Commons

Sameh S. Ali,

Rania Al-Tohamy,

Majid Al-Zahrani

et al.

Microbial Cell Factories, Journal Year: 2025, Volume and Issue: 24(1)

Published: March 10, 2025

Abstract The increasing global demand for sustainable protein sources necessitates the exploration of alternative solutions beyond traditional livestock and crop-based proteins. Microalgae present a promising due to their high content, rapid biomass accumulation, minimal land water requirements. Furthermore, ability thrive on non-arable in wastewater systems enhances sustainability resource efficiency. Despite these advantages, scalability economical feasibility remain major challenges microalgal production. This review explores recent advancements cultivation extraction technologies, including pulsed electric field, ultrasound-assisted extraction, enzyme-assisted microwave-assisted extraction. These innovative techniques have significantly improved efficiency, purity, sustainability, while addressing cell wall disruption recovery challenges. Additionally, examines digestibility bioavailability, particularly context human nutrition aquafeed applications. A critical analysis life cycle assessment studies highlights environmental footprint production compared conventional sources. Although requires significant energy inputs, biorefinery approaches, carbon dioxide sequestration, industrial integration can help mitigate limitations. Finally, this outlines key future research directions, emphasizing need cost reduction strategies, genetic engineering enhanced yields, industrial-scale process optimization. By integrating with models, proteins hold immense potential as sustainable, high-quality source food, feed, nutraceutical

Language: Английский

Citations

0
From injury to repair: the therapeutic potential of induced pluripotent stem cells in heart failure DOI Creative Commons
Tadahisa Sugiura, Sheeza Nawaz, Dhienda C. Shahannaz

et al.

Regenerative medicine reports ., Journal Year: 2025, Volume and Issue: 2(1), P. 22 - 30

Published: March 1, 2025

Heart failure is a complex clinical syndrome characterized by the heart’s inability to pump sufficient blood meet body’s metabolic demands, resulting in symptoms such as dyspnea, fatigue, and fluid retention. Despite significant advances pharmacological treatments device therapies, prognosis for patients with advanced heart remains poor. This underscores urgent need innovative regenerative therapies aimed at restoring cardiac function improving quality of life suffering from this debilitating condition. article provides comprehensive overview pathophysiologic mechanisms underlying end-stage failure, which include myocardial systolic diastolic dysfunction, neuroendocrine activation, inflammation, oxidative stress. Collectively, these lead progressive deterioration structure function, culminating failure. The also examines differences between ischemic non-ischemic cardiomyopathies their implications treatment strategies prognosis. Furthermore, review explores application medicine focusing on its potential repair functional recovery. In field medicine, induced pluripotent stem cells derived cardiomyocytes are considered cutting-edge technologies repair. Induced can differentiate into cardiomyocytes, thereby offering new hope regeneration. However, current research faces several challenges, including maturity integration immunogenicity concerns, difficulties scaling up production applications. Additionally, ethical issues related cell technology, sourcing tumorigenic risks, must be carefully addressed. highlights technology treating while emphasizing complexities involved transitioning laboratory practice.

Language: Английский

Citations

0
The Art of Neuroregeneration De Novo and In Situ DOI
Eumorphia Remboutsika

Advances in experimental medicine and biology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Developments, Applications, and Innovations in Agricultural Sciences and Biotechnologies DOI Creative Commons
Anzhen Qin,

Dongfeng Ning

Applied Sciences, Journal Year: 2025, Volume and Issue: 15(8), P. 4381 - 4381

Published: April 16, 2025

The global population is projected to reach approximately 10 billion by 2050, and the demand for food expected increase 60–70% [...]

Language: Английский

Citations

0
From lab to industry: Technologies and challenges for scaling up bioprocesses in cell-based food production DOI
Xin Guan,

Wanqiang Sun,

Zhenwu Ma

et al.

Trends in Food Science & Technology, Journal Year: 2025, Volume and Issue: unknown, P. 105040 - 105040

Published: April 1, 2025

Language: Английский

Citations

0
High-throughput proliferation and activation of NK-92MI cell spheroids via a homemade one-step closed bioreactor in pseudostatic cultures for immunocellular therapy DOI Creative Commons
Jhih‐Ni Lin, Che‐Yung Kuan,

Chia‐Ting Chang

et al.

Journal of Biological Engineering, Journal Year: 2024, Volume and Issue: 18(1)

Published: Nov. 12, 2024

Abstract The NK-92MI cell line has displayed significant promise in clinical trials for cancer treatment. However, challenges persist obtaining sufficient quantities and achieving optimal cytotoxicity. proliferation of natural killer (NK) cells involves the formation aggregates, but excessively large aggregates can impede nutrient waste transport, leading to reduced survival rates. In this study, a custom bioreactor was designed mimic pseudostatic culture conditions by integrating brief mechanical rotation during 6-h static period. This method aimed achieve an aggregate size while improving viability. findings revealed 144-fold expansion 3D reaching ideal 80–150 µm, significantly increasing both After 14 days culture, maintained their phenotype subsequent phase activation. Moreover, these presented elevated levels IFN-γ expression after IL-18 activation, resulting enhanced NK cell-mediated cytotoxicity against K562 cells. innovative strategy, which uses closed suspension-based system, presents promising approach activation techniques immunocellular therapy.

Language: Английский

Citations

0