Biology, Journal Year: 2025, Volume and Issue: 14(4), P. 397 - 397
Published: April 10, 2025
Cardiovascular disease remains a leading cause of morbidity and mortality worldwide, requiring both pharmacological lifestyle-based preventive strategies. Artichoke (Cynara cardunculus L. var. scolymus) has gained attention for its health benefits, including choleretic lipid-lowering activities. However, cardiovascular effects remain underdiscussed. This paper provides critical review the current literature on artichoke, with focus underlying mechanisms action clinical efficacy. Experimental studies assessing artichoke’s endothelial function, vascular smooth muscle relaxation, modulation renin–angiotensin–aldosterone axis were assessed. Additionally, studies, systematic reviews, meta-analyses investigating antihypertensive reviewed. bioactive components, particularly flavonoids caffeoylquinic acids, enhance endothelial-dependent -independent vasorelaxation inhibit angiotensin-converting enzyme activity. Although indicate improvements in flow-mediated dilation, they report only modest reductions blood pressure, high variability formulations, dosages, patient populations. While artichoke supplementation may support pressure regulation health, evidence suggests it should be considered an adjunct rather than replacement conventional therapy. Standardized formulations well-controlled will required to clarify therapeutic role.
Language: Английский