MoS2-based biosensor for SARS-CoV-2 detection: a numerical approach

Frontiers in Nanotechnology, Journal Year: 2025, Volume and Issue: 6

Published: Jan. 7, 2025

Surface plasmon resonance (SPR) biosensors are powerful tools for highly sensitive and specific detection of biomolecules. This study introduces a MoS₂-based SPR biosensor optimized SARS-CoV-2 detection. The sensor integrates multilayer configuration, including BK7 prism, Ag film (45 nm), S₃N₄ layer (13 MoS₂ monolayer (0.65 functionalized ssDNA (5 nm). Systematic optimization each improved plasmonic coupling, propagation, specificity, achieving balance between sensitivity, resolution, efficiency. was evaluated across virus concentrations ranging from 0.01 to 150 mM. proposed demonstrated excellent performance at moderate high concentrations, with sensitivity up 261.33°/RIU, quality factor 36.16 RIU −1 , limit 1.91 × 10 −5 . An optimal figure merit 405.50 achieved mM, highlighting the sensor’s diagnostic potential. However, challenges remain very low (0.01–0.1 mM), where angular shifts, signal-to-noise ratio were negligible.

Language: Английский

WS2/Si3N4-Based Biosensor for Low-Concentration Coronavirus Detection

Micromachines, Journal Year: 2025, Volume and Issue: 16(2), P. 128 - 128

Published: Jan. 23, 2025

This study presents the optimization of two SPR biosensors, Sys3 and Sys5, for SARS-CoV-2 detection at concentrations 0.01-100 nM. Sys3, with a 55 nm silver layer, 13 silicon nitride 10 ssDNA achieved figure merit (FoM) 571.24 RIU-1, signal-to-noise ratio (SNR) 0.12, accuracy (DA) 48.93 × 10-2. incorporating 50 1.6 tungsten disulfide layer (L = 2), demonstrated higher sensitivity 305.33 °/RIU lower limit (LoD) 1.65 10-5. outshined in precision low attenuation (<1%), while Sys5 provided enhanced limits, crucial early-stage viral detection. These configurations align refractive index ranges clinical samples, showcasing their diagnostic potential. Future work will focus on experimental validation integration into point-of-care platforms.

Language: Английский

Photonic Crystal Fiber Plasmonic Biosensor for SARS-CoV-2 Particle Quantification and Detection

Plasmonics, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

Language: Английский