An Overview of the Etiopathogenic Mechanisms Involved in the Expression of the Oral Microbiota DOI Creative Commons

Ion Alexandru Popovici,

Cristian Ionuț Orășanu,

Georgeta-Camelia Cozaru

et al.

Clinics and Practice, Journal Year: 2025, Volume and Issue: 15(4), P. 80 - 80

Published: April 11, 2025

Background/Objectives: The diversity of the oral microbiota exerts its effects in maintaining dental and overall health. unique genetic profile each individual influences composition microbiota, determining susceptibility to certain diseases. aim is observe role by highlighting pathogenic mechanisms involved dysbiosis identify determinism’s influence balance. Methods: This study was designed as a narrative review utilizing some principles guidelines systematic increase methodological rigor. We examined 121 articles such reviews, meta-analyses, editorials, observational studies, which met inclusion exclusion criteria. criteria for studies were follows: (1) that evaluated impact or/and systemic diseases; (2) observed microbiota; (3) interaction with immune system (4); implications microbiota. Results: Host genes regulate inflammatory immunological reactions play microbiological explains increased resistance diseases, including gingivitis or periodontitis. Also, are reflected not only locally, but also generally, being associated various conditions. Conclusions: Understanding determinants may help create individualized therapies preventing managing disorders. A healthy lifestyle adequate hygiene can facilitate diverse balanced microbiome, crucial

Language: Английский

An Overview of the Etiopathogenic Mechanisms Involved in the Expression of the Oral Microbiota DOI Creative Commons

Ion Alexandru Popovici,

Cristian Ionuț Orășanu,

Georgeta-Camelia Cozaru

et al.

Clinics and Practice, Journal Year: 2025, Volume and Issue: 15(4), P. 80 - 80

Published: April 11, 2025

Background/Objectives: The diversity of the oral microbiota exerts its effects in maintaining dental and overall health. unique genetic profile each individual influences composition microbiota, determining susceptibility to certain diseases. aim is observe role by highlighting pathogenic mechanisms involved dysbiosis identify determinism’s influence balance. Methods: This study was designed as a narrative review utilizing some principles guidelines systematic increase methodological rigor. We examined 121 articles such reviews, meta-analyses, editorials, observational studies, which met inclusion exclusion criteria. criteria for studies were follows: (1) that evaluated impact or/and systemic diseases; (2) observed microbiota; (3) interaction with immune system (4); implications microbiota. Results: Host genes regulate inflammatory immunological reactions play microbiological explains increased resistance diseases, including gingivitis or periodontitis. Also, are reflected not only locally, but also generally, being associated various conditions. Conclusions: Understanding determinants may help create individualized therapies preventing managing disorders. A healthy lifestyle adequate hygiene can facilitate diverse balanced microbiome, crucial

Language: Английский

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