Long COVID and pituitary dysfunctions: a bidirectional relationship?

Pituitary, Journal Year: 2024, Volume and Issue: 27(6), P. 955 - 969

Published: Sept. 6, 2024

Language: Английский

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Review of the relationship between growth hormone and SARS-CoV-2 infection

Future Virology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 15

Published: April 11, 2025

Language: Английский

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Sex differences of post-Covid patients undergoing outpatient pulmonary rehabilitation

Biology of Sex Differences, Journal Year: 2024, Volume and Issue: 15(1)

Published: April 21, 2024

Abstract Background Following years of pandemic severe acute respiratory syndrome coronavirus 2 infections labelled Covid-19, long lasting impairment summarized as post-Covid (PCS) challenges worldwide healthcare. Patients benefit from rehabilitation programs, but sex specific aspects improvement remain little understood. The aim the study was to assess whether women and men differ in response outpatient pulmonary for PCS. Methods 263 (54.4% female) patients partaking (OPR) due PCS between March 2020 July 2022 were included a prospective observational cohort study. Outcomes assessed at baseline before discharge OPR six-minute walking distance (6MWD), 1-second forced expiratory volume (FEV1), diffusion capacity carbon monoxide, maximal inspiratory pressure (MIP), dyspnea (medical research council scale), functional status scale (PCFS). Sexspecific changes outcomes following by linear mixed model presented mean differences (MD) with 95% confidence intervals. Linear regression applied test 6MWD correlates PCFS minimal clinically important difference (MCID) regarding an least one point computed logistic regression. Results Significant throughout observed all (all p < 0.0001). Despite less Covid-19 infections, scores remained higher females after ( = 0.004) only 19.4% compared 38.5% achieved remission impairment. At well OPR, showed symptom load 0.0027) scored lower FEV1 0.009) MIP 0.0006) assessment. Performance comparable women. An increase 35 m improve Conclusion Both subjective symptoms such fatigue objective performance function more frequently among both men, sex-gap could not be closed often Intensified treatment these should considered undergoing

Language: Английский

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Brain Mechanisms Involved in Post COVID Syndrome: A Narrative Review

Neurochemical Journal, Journal Year: 2024, Volume and Issue: 18(3), P. 397 - 405

Published: Sept. 1, 2024

Language: Английский

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Implications of Dysnatremia and Endocrine Disturbances in COVID-19 Patients

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(18), P. 9856 - 9856

Published: Sept. 12, 2024

Sodium imbalance is a common electrolyte disturbance in COVID-19, often linked to disruptions hormonal regulation. This review explores the relationship between sodium dysregulation and endocrine disturbances, particularly focusing on primary secondary hypothyroidism, hypocortisolism, renin-angiotensin-aldosterone system (RAAS). Hypocortisolism due adrenal insufficiency or pituitary dysfunction, can lead hyponatremia through inadequate cortisol levels, which impair renal free water excretion enhance antidiuretic hormone (ADH) secretion. Similarly, hypothyroidism associated with decreased blood flow glomerular filtration rate (GFR), also increases ADH activity, leading retention dilutional hyponatremia. Furthermore, COVID-19 disrupt RAAS (primarily its interaction angiotensin-converting enzyme 2 (ACE2) receptor), diminishing aldosterone secretion further contributing loss These suggest that multifactorial warrants investigation into complex interplay function, homeostasis. Future research should focus understanding these mechanisms develop management algorithms address both underlying disturbances order improve prognosis outcomes patients.

Language: Английский

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Characterization of Unusual Serogroups of Neisseria meningitidis

Microorganisms, Journal Year: 2024, Volume and Issue: 12(12), P. 2528 - 2528

Published: Dec. 7, 2024

Most cases of invasive meningococcal disease (IMD) in Europe are caused by isolates the Neisseria meningitidis serogroups B, C, W, and Y. We aimed to explore other unusual serogroups. retrospectively screened IMD databases National Reference Center for Meningococci Haemophilus influnezae France between 2014 2023. Age, sex, serogroups, genetic lineage distributions were analyzed. also measured complement deposition on bacterial surface tested coverage vaccines against serogroup B. Cases due than Y represented 1.6% all 3610 during study period with 59 a median age 21.5 years age. The corresponding non-groupable (26 cases), X (21 E (11 one isolate belonged Z. Only low proportion (7.4%) hyperinvasive lineages. Isolates bound significantly higher amount their mainly detected patients terminal pathway deficiencies. these shown be covered licensed meningococci Surveillance needs enhanced.

Language: Английский

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Response to Letter to the Editor From Josef Finsterer: “Explaining Long COVID: A Pioneer Cross-Sectional Study Supporting the Endocrine Hypothesis”

Journal of the Endocrine Society, Journal Year: 2024, Volume and Issue: 8(7)

Published: April 26, 2024

Language: Английский

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Pituitary Apoplexy: Description of Medical and Surgical Treatment and Clinical, Visual, and Endocrinological Outcomes During the SARS-CoV-2 Pandemic and Over Three Years

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: June 25, 2024

Pituitary apoplexy (PA) is a rare neuroendocrinological emergency. The SARS-CoV-2 pandemic recommendations led to shift in the management of patients with pituitary diseases, especially decision-making between conservative and surgical treatment PA.

Language: Английский

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