Guanidinium and spermidinium decavanadates: as small biomimetic models to understand non-covalent interactions between decavanadate and arginine and lysine side chains in proteins DOI Creative Commons

Luis F. Paredes-Pérez,

Ángel Mendoza, Amalia García-García

et al.

Frontiers in Chemical Biology, Journal Year: 2024, Volume and Issue: 3

Published: Aug. 12, 2024

During the last three decades, numerous investigations have been conducted on polyoxidovanadates to treat several illnesses and inhibit enzymes. Numerous decavanadate compounds proposed as potential therapies for Diabetes mellitus, Cancer, Alzheimer’s disease. Only six relevant functional proteins interacting with decavanadate, V 10 , deposited in PDB. These are acid phosphatase, tyrosine kinase, two ecto-nucleoside triphosphate diphosphohydrolases (NTPDases), human transient receptor cation channel (TRPM4), cell cycle protein CksHs1. The interaction sites these mainly consist of Arginine Lysine, side chains binding anion. To get further knowledge regarding non-covalent interactions environments, guanidinium spermidinium decavanadates were synthesized, crystallized, subjected analysis utilizing various techniques, including FTIR, Raman, 51 V-NMR, TGA, X-ray diffraction. DFT calculations employed calculate energy between anion organic counterions. Furthermore, Quantum Theory Atoms Molecules (QTAIM) Non-covalent Interaction-Reduced Density Gradient (NCI-RDG) analyses understand present adducts. Decavanadate can engage electrostatic forces, van der Waals, hydrogen bond spermidinium, shown by their respective energies. Both highly stabilized strong N−H···O weak C−H···O. In addition, cations form stable rings. This study provides new information intermolecular small biomimetic models arginine lysine lateral environments.

Language: Английский

Neuroprotective Effect of Curcumin–Metavanadate in the Hippocampus of Aged Rats DOI Open Access

Sonia Irais González‐Cano,

Ulises Peña‐Rosas,

Guadalupe Muñoz‐Arenas

et al.

Synapse, Journal Year: 2025, Volume and Issue: 79(1)

Published: Jan. 1, 2025

ABSTRACT Brain aging is a multifactorial process that includes reduction in the biological and metabolic activity of individuals. Oxidative stress inflammatory processes are characteristic brain aging. Given current problems, need arises to implement new therapeutic approaches. Polyoxidovanadates (POV), as well curcumin, have stood out for their participation variety activities. This work aimed evaluate coupling metavanadate curcumin (Cuma‐MV) on learning, memory, redox balance, neuroinflammation, cell death hippocampal region (CA1 CA3) dentate gyrus (DG) aged rats. Rats 18 months old were administered daily dose (Cuma), sodium (MV), or Cuma‐MV two months. The results demonstrated administration 60 days rats improved short‐ long‐term recognition decreased reactive oxygen species, substantially lipoperoxidation hippocampus. Furthermore, superoxide dismutase catalase increased animals treated with Cuma‐MV. It important highlight treatment exhibited significantly greater effect than treatments MV Cuma all parameters evaluated. Finally, we conclude represents potential option prevention cognitive decline associated

Language: Английский

Citations

0
Beyond Chemistry: Investigating the Physical, Pharmacological, and Computational Aspects of Polyoxometalate Integrated Solid Lipid Nanoparticles for Cancer Treatment DOI Creative Commons

Riffat Khan,

Ume Ruqia Tulain, Hamid Saeed Shah

et al.

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 445 - 464

Published: Jan. 1, 2025

The solid lipid nanoparticles of transitional metal complexes (POMs) were prepared with natural lipids the aim developing a safer therapeutic approach for cancer treatment. Natural used to create containing (POMs). had displayed appreciable entrapment and loading percentage P5W30. zeta capacitance was measured be -32.57±6.44 mV average particle dimension 160.5±8.61 nm polydispersity index (PDI) around 0.3814±0.096. effectiveness P5W30-BW-SLNs in inhibiting growth HeLa cells found higher (IC50 = 3.02±2.14 µg/mL) compared pure P5W30 7.93±5.08 µg/mL). Further examinations DNA damage made through comet test flow cytometry techniques. assessment tumor regression survival conducted, comparison recorded. resulted 72.91% increase rates reduction burden by 2.967±0.543%. Moreover, computational findings demonstrate strong connection actual data, providing plausible explanation notable chemopreventive efficacy POM against cell lines. study's might pave way more efficient delivery system

Language: Английский

Citations

0
Donut-shaped [NaP5W30O110]14− polyoxometalate as a promising antidiabetic drug-candidate: putative mechanisms of action DOI
Marko Dinčić, Mirjana B. Čolović, Jasna Todorović

et al.

JBIC Journal of Biological Inorganic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

Language: Английский

Citations

0
Selected Papers from the XXI SPB National Congress of Biochemistry 2021 DOI Creative Commons
Manuel Aureliano, M. Leonor Cancela, Ana Rodrigues Costa

et al.

BioChem, Journal Year: 2025, Volume and Issue: 5(2), P. 7 - 7

Published: April 10, 2025

The XXI SPB National Congress of Biochemistry 2021 was held at the University Évora in Portugal on 14–16 October [...]

Language: Английский

Citations

0
One-pot synthesis, structural investigation, antitumor activity and molecular docking approach of two decavanadate compounds DOI

Rihab Dridi,

Zaineb Abdelkafi-Koubaa,

Najet Srairi‐Abid

et al.

Journal of Inorganic Biochemistry, Journal Year: 2024, Volume and Issue: 255, P. 112533 - 112533

Published: March 22, 2024

Language: Английский

Citations

3
Synthesis, crystal structure, computational and solution studies of a new phosphotetradecavanadate salt. Assessment of its effect on U87 glioblastoma cells DOI Creative Commons
Rim Zarroug, Wassim Moslah, Najet Srairi‐Abid

et al.

Journal of Inorganic Biochemistry, Journal Year: 2025, Volume and Issue: 269, P. 112882 - 112882

Published: March 9, 2025

Language: Английский

Citations

0
Interaction of Vanadium Complexes with Proteins: Revisiting the Reported Structures in the Protein Data Bank (PDB) since 2015 DOI Creative Commons
Marino F. A. Santos, João Costa Pessoa

Molecules, Journal Year: 2023, Volume and Issue: 28(18), P. 6538 - 6538

Published: Sept. 9, 2023

The structural determination and characterization of molecules, namely proteins enzymes, is crucial to gaining a better understanding their role in different chemical biological processes. continuous technical developments the experimental computational resources X-ray diffraction (XRD) and, more recently, cryogenic Electron Microscopy (cryo-EM) led an enormous growth number structures deposited Protein Data Bank (PDB). Bioinorganic chemistry arose as relevant discipline biology therapeutics, with massive studies reporting effects metal complexes on systems, vanadium being one systems addressed. In this review, we focus interactions compounds (VCs) proteins. Several types binding are established between VCs proteins/enzymes. Considering that V-species bind may differ from those initially added, mentioned techniques pivotal clarifying nature variety proposing mechanisms involved either enzymatic inhibition or catalysis. As such, provide account available information bound obtained by both XRD and/or cryo-EM, mainly exploring recent structures, particularly containing organic-based complexes.

Language: Английский

Citations

8
Editorial: Emerging polyoxometalates with biological, biomedical, and health applications DOI Creative Commons
Manuel Aureliano, Scott G. Mitchell, Panchao Yin

et al.

Frontiers in Chemistry, Journal Year: 2022, Volume and Issue: 10

Published: Aug. 9, 2022

EDITORIAL article Front. Chem., 09 August 2022Sec. Inorganic Chemistry https://doi.org/10.3389/fchem.2022.977317

Language: Английский

Citations

11
Multi-CeIII-Inserted Phospho(III)tungstate Containing Three Building Units with Prominent Peroxidase-Mimicking Activity for Detecting l-Cysteine DOI

Baoxing Zeng,

Yanzhou Li, Guoping Liu

et al.

Inorganic Chemistry, Journal Year: 2023, Volume and Issue: 62(26), P. 10351 - 10358

Published: June 21, 2023

An attractive isonicotinic acid-ornamented octa-CeIII-inserted phospho(III)tungstate [H2N(CH3)2]6Na8[Ce8(H2O)30W8Na2O20(INA)4][HPIIIW4O17]2[HPIIIW9O33]4·30H2O (1-Ce) (HINA = acid) has been isolated through the deliberately designed one-step assembly strategy, in which HPO32- heteroanion template was introduced into Ce3+/WO42- system presence of HINA. The polyoxoanion 1-Ce consists two identical [Ce4(H2O)15W4NaO10(INA)2][HPIIIW4O17][HPIIIW9O33]2}7- subunits linked by Ce-O-W bonds. exhibits three kinds polyoxotungstate building blocks [W4NaO20(INA)2]17-, [HPIIIW4O17]6-, and [HPIIIW9O33]8-, [W4NaO20(INA)2]17- [HPIIIW4O17]6- units can be considered as seeds driven coordination additional Ce3+ ions to induce aggregation [HPIIIW9O33]8- fragments. Furthermore, possesses high peroxidase-like activity oxidize 3,3',5,5'-tetramethylbenzidine H2O2 with a turnover rate 6.20 × 10-3 s-1. Because l-cysteine (l-Cys) reduce oxTMB TMB, detection l-Cys established based on 1-Ce-based colorimetric biosensing platform linear range 5-100 μM limit 4.28 μM. This work not only expand scientific research studies chemistry materials rare-earth-inserted polyoxotungstates but also provide practical application possibility clinical diagnosis using liquid biopsy.

Language: Английский

Citations

6
Water-Soluble Polyoxometal Clusters of Molybdenum (V) with Pyrazole and Triazole: Synthesis and Study of Cytotoxicity and Antiviral Activity DOI Creative Commons
A. V. Konkova, Iulia V. Savina, Darya V. Evtushok

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(24), P. 8079 - 8079

Published: Dec. 14, 2023

Among well-studied and actively developing compounds are polyoxometalates (POMs), which show application in many fields. Extending this class of compounds, we introduce a new subclass polyoxometal clusters (POMCs) [Mo12O28(μ-L)8]4- (L = pyrazolate (pz) or triazolate (1,2,3-trz 1,2,4-trz)), structurally similar to POM, but containing binuclear Mo2O4 linked by bridging oxo- organic ligands. The complexes obtained ampoule synthesis from the cluster [Mo2O4(C2O4)2(H2O)2]2- melt an ligand soluble stable aqueous solutions. In addition detailed characterization solid state solution, biological properties on normal cancer cells were investigated, antiviral activity against influenza A virus (subtype H5N1) was demonstrated.

Language: Английский

Citations

6