Cardiovascular Nanomedicine: From Targeted Delivery to Theranostics DOI
Maryam Rezvani, Nejat Düzgüneş

Royal Society of Chemistry eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 18

Published: Oct. 25, 2024

Despite extensive efforts to find effective strategies combat cardiovascular disorders, the annual death toll from these diseases is enormous worldwide. Cardiovascular nanomedicine as an innovative technology has played a remarkable role in overcoming various therapeutic and diagnostic challenges. Stimuli-responsive multifunctional nanocarriers have been efficiently developed for targeted delivery of agents pathological sites. Nanoplatforms used carriers imaging or sensors detect biomarkers can reduce detection time, increase sensitivity provide real-time monitoring disorders. Furthermore, ability accumulate at target site, combined with multimodal techniques, leads accurate results. Theranostic nanosystems personalized treatment plan precisely guide therapy process by combining aspects. This chapter highlights recent advances nanomedicine.

Language: Английский

Bioactive Phenolics of Hyoscyamus muticus L. Subsp. Falezlez: A Molecular and Biochemical Approach to Antioxidant and Urease Inhibitory Activities DOI Open Access
Sabrina Lekmine, Ouided Benslama, Bachir Bensalah

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(1), P. 370 - 370

Published: Jan. 4, 2025

This study examines the chemical composition, antioxidant properties, and urease inhibitory effects of Hyoscyamus muticus L. subsp. falezlez (Coss.) Maire. Using LC-ESI-MS/MS, 19 distinct phenolic compounds were identified, with chlorogenic acid being most abundant. The ethanol extract demonstrated notable activity, highlighting its potential for therapeutic use. Urease inhibition assays revealed a remarkable 91.35% by H. extract, an IC50 value 5.6 ± 1.20 μg/mL, indicating promising role in addressing conditions linked to activity. Molecular docking studies further investigated interaction between urease, identifying hyperoside as leading candidate, binding energy −7.9 kcal/mol. Other compounds, such rutin, luteolin, apigenin, kaempferol, hesperetin, acid, rosmarinic also significant affinities, suggesting their disrupt function. These findings highlight source natural bioactive offering avenues development novel treatments urease-related disorders oxidative stress.

Language: Английский

Citations

3
From gut to liver: Exploring the crosstalk between gut-liver axis and oxidative stress in metabolic dysfunction-associated steatotic liver disease DOI Creative Commons

Mi Zhou,

Jianyu Lv, Han Y. H. Chen

et al.

Annals of Hepatology, Journal Year: 2025, Volume and Issue: unknown, P. 101777 - 101777

Published: Jan. 1, 2025

Non-alcoholic fatty liver disease (NAFLD), now recognized as metabolic dysfunction-associated steatotic (MASLD), represents a significant and escalating global health challenge. Its prevalence is intricately linked to obesity, insulin resistance, other components of the syndrome. As our comprehension MASLD deepens, it has become evident that this condition extends beyond liver, embodying complex, multi-systemic with hepatic manifestations mirror broader landscape. This comprehensive review delves into critical interplay between gut-liver axis oxidative stress, elucidating their pivotal roles in etiology progression MASLD. Our analysis reveals several key findings: (1) Bile acid dysregulation can trigger stress through enhanced ROS production hepatocytes Kupffer cells, leading mitochondrial dysfunction lipid peroxidation; (2) Gut microbiota dysbiosis disrupts intestinal barrier function, allowing increased translocation endotoxins like LPS, which activate inflammatory pathways TLR4 signaling promote via NADPH oxidase activation; (3) The redox-sensitive transcription factors NF-κB Nrf2 serve crucial mediators axis, regulating responses orchestrating antioxidant defenses; (4) Oxidative stress-induced damage function creates destructive feedback loop, further exacerbating inflammation progression. These findings highlight complex interrelationship pathogenesis, suggesting potential therapeutic targets for management.

Language: Английский

Citations

2
The Effect of β-Glucan on the Release and Antiradical Activity of Phenolic Compounds from Apples in Simulated Digestion DOI Creative Commons
Lidija Jakobek, Daniela Kenjerić, Lidija Šoher

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(2), P. 301 - 301

Published: Jan. 14, 2025

Beneficial activities of phenolic compounds in the gastrointestinal tract, such as antiradical activity, are affected by food matrix. The aim this study was to investigate influence one constituent matrix (dietary fiber β-glucan) on release and activity from apples digestion. Simulated digestion vitro conducted whole without or with added β-glucan. Antiradical determined DPPH method. total amount released stomach (563 mg kg−1 fresh weight (fw), 85%) decreased intestine (314 fw, 47%) (p < 0.05). presence β-glucan 80 74% 44 40% small when there were lower higher amounts, respectively. A statistical analysis showed differences between B-glucan adsorbed up 24 (stomach) 32 g−1 (small intestine) phenolics. Phenolic scavenged more free radicals than stomach, but not significantly. interaction should be considered explaining beneficial effects intestine.

Language: Английский

Citations

0
Nanomedicine approaches for healing chronic wounds: recent advances and future opportunities DOI
Maryam Rezvani, Nejat Düzgüneş,

Tanveer A. Tabish

et al.

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 393 - 415

Published: Jan. 1, 2025

Language: Английский

Citations

0
Suramin Exerts an Ameliorative Effect on Acetic Acid-Induced Acute Colitis in Rats by Demonstrating Potent Antioxidant and Anti-Inflammatory Properties DOI Creative Commons
Gülçin Ercan, Hatice Aygün, Ahmet Akbaş

et al.

Medicina, Journal Year: 2025, Volume and Issue: 61(5), P. 829 - 829

Published: April 30, 2025

Background and Objectives: The purpose of this study was to evaluate potential protective effects suramin on inflammation, oxidative stress, histopathological damage a rat model acute colitis created with acetic acid. Materials Methods: Wistar albino (male) rats were randomly assigned three groups: control (n = 10), + saline 10). Rectal instillation 4% acid used induce colitis. Suramin (10 mg/kg/day) or administered intraperitoneally for 15 days. Plasma concentrations pentraxin 3 (PTX3), tumor necrosis factor-alpha (TNF-α), neutrophil extracellular traps (NETs), malondialdehyde (MDA) determined using enzyme-linked immunosorbent assay (ELISA) spectrophotometric methods. In addition, vascular endothelial growth factor (VEGF) TNF-α levels in colonic tissue also measured. Histopathological evaluations conducted hematoxylin eosin staining. Results: Significant increases plasma inflammatory markers, stress parameters, scores observed when compared group; values higher group. treatment significantly reduced PTX3, TNF-α, NETs, MDA levels, VEGF the untreated Histological analysis showed epithelial injury leukocyte presence receiving suramin. Conclusions: Our findings demonstrate that attenuates an experimental These results suggest may possess therapeutic intestinal inflammation; however, effect requires further support through advanced clinical studies.

Language: Английский

Citations

0
Cardiovascular Nanomedicine: From Targeted Delivery to Theranostics DOI
Maryam Rezvani, Nejat Düzgüneş

Royal Society of Chemistry eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 18

Published: Oct. 25, 2024

Despite extensive efforts to find effective strategies combat cardiovascular disorders, the annual death toll from these diseases is enormous worldwide. Cardiovascular nanomedicine as an innovative technology has played a remarkable role in overcoming various therapeutic and diagnostic challenges. Stimuli-responsive multifunctional nanocarriers have been efficiently developed for targeted delivery of agents pathological sites. Nanoplatforms used carriers imaging or sensors detect biomarkers can reduce detection time, increase sensitivity provide real-time monitoring disorders. Furthermore, ability accumulate at target site, combined with multimodal techniques, leads accurate results. Theranostic nanosystems personalized treatment plan precisely guide therapy process by combining aspects. This chapter highlights recent advances nanomedicine.

Language: Английский

Citations

0