Перспективи та інновації науки,
Journal Year:
2023,
Volume and Issue:
16(34)
Published: Dec. 29, 2023
ЕВОЛЮЦІЯ
МЕДИЧНОЇ
ПАРАДИГМИ:
ВИКЛИКИ
ТА
ПЕРСПЕКТИВИ
У
ВНУТРІШНІЙ
МЕДИЦИНІАнотація.Авторами
статті
досліджена
динаміка
розвитку
внутрішньої
медицини
в
контексті
сучасних
трансформацій
медичної
науки
та
практики.Проведений
аналіз
ключових
викликів,
які
стоять
перед
сучасною
медициною,
спрогнозовані
ймовірні
перспективи.Особлива
увага
приділяється
науковим
інноваціям,
технологічним
досягненням
персоналізованим
підходам
до
діагностики
й
лікування
на
основі
аналізу
досліджень
вітчизняних
зарубіжних
науковців
власного
досвіду.Розглядається
вплив
технологій,
зміни
структурі
захворювань
глобальні
виклики
сучасну
медичну
практику.Стаття
спрямована
визначення
шляхів
оптимізації
вдосконалення
у
світлі
нових
можливостей
Biomaterials Science,
Journal Year:
2024,
Volume and Issue:
12(7), P. 1914 - 1923
Published: Jan. 1, 2024
A
novel
meshed
ADS
combined
with
NPWT
can
reduce
the
risk
of
scaffold-related
complications,
which
helps
to
improve
quality
wound
repair
and
promotes
a
broader
range
applications.
hLife,
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 1, 2024
Organoids
are
in
vitro
microstructures
similar
to
the
source
tissue
formed
by
self-organizing
construction
of
stem
cells
from
various
sources.
It
is
now
widely
recognized
as
a
powerful
model
facilitate
cancer
research
and
personalized
precision
therapy.
Since
successful
establishment
first
organoid
2009,
there
has
been
global
upsurge
research.
At
present,
organoids
have
used
on
mechanism
occurrence
development,
study
cell
interactions
tumor
microenvironment,
development
screening
new
drugs,
individualized
treatment
cancer.
In
addition,
chip
technology
biobanks
expected
further
promote
irreplaceable
role
medical
treatment.
this
review,
we
offer
comprehensive
outline
historical
their
advantages,
focusing
latest
progress
application
We
also
discuss
problems
that
need
be
solved
potential
applications
organoids.
This
review
summarizes
impact
treatment,
provide
view
Heliyon,
Journal Year:
2023,
Volume and Issue:
10(1), P. e23504 - e23504
Published: Dec. 9, 2023
With
the
burgeoning
advancements
in
disease
modeling,
drug
development,
and
precision
medicine,
organ-on-a-chip
has
risen
to
forefront
of
biomedical
research.
Specifically
tumor
research,
this
technology
exhibited
exceptional
potential
elucidating
dynamics
metastasis
within
microenvironment.
Recognizing
significance
field,
our
study
aims
provide
a
comprehensive
bibliometric
analysis
global
scientific
contributions
related
organ-on-a-chip.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2024,
Volume and Issue:
12
Published: Feb. 7, 2024
Liver
bioengineering
stands
as
a
prominent
alternative
to
conventional
hepatic
transplantation.
Through
liver
decellularization
and/or
bioprinting,
researchers
can
generate
acellular
scaffolds
overcome
immune
rejection,
genetic
manipulation,
and
ethical
concerns
that
often
accompany
traditional
transplantation
methods,
in
vivo
regeneration,
xenotransplantation.
Hepatic
cell
lines
derived
from
induced
pluripotent
stem
cells
(iPSCs)
repopulate
decellularized
bioprinted
scaffolds,
producing
an
increasingly
functional
organ
potentially
suitable
for
autologous
use.
In
this
mini-review,
we
overview
recent
advancements
vitro
hepatocyte
differentiation
protocols,
shedding
light
on
their
pivotal
role
recellularization
thereby
offering
novel
source
Finally,
identify
future
directions
research
may
allow
the
implementation
of
these
systems
diverse
applications,
including
drug
screening
disease
modeling.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 17, 2024
Abstract
Dynamic
growth
factor
presentation
influences
how
individual
endothelial
cells
assemble
into
complex
vascular
networks.
Here,
we
developed
programmable
bioinks
that
facilitate
dynamic
VEGF
to
guide
morphogenesis
within
3D-bioprinted
constructs.
We
leveraged
aptamer’s
high
affinity
for
rapid
sequestration
in
spatially
confined
regions
and
utilized
aptamer-complementary
sequence
(CS)
hybridization
tune
release
kinetics
temporally,
days
after
bioprinting.
show
spatial
resolution
of
bioink,
combined
with
CS-triggered
release,
significantly
alignment,
organization,
microvascular
networks
bioprinted
The
presence
aptamer-tethered
the
generation
instantaneous
gradients
upon
CS-triggering
restricted
hierarchical
network
formation
printed
aptamer
at
all
resolutions.
Network
properties
improved
as
decreased,
low-resolution
designs
yielding
highest
properties.
Specifically,
CS-treated
exhibited
significant
remodeling,
increase
vessel
density(1.35-fold),
branching
density(1.54-fold),
average
length(2.19-fold)
compared
non-treated
samples.
Our
results
suggests
CS
acts
an
external
trigger
capable
inducing
time-controlled
changes
organization
alignment
on-demand
localized
a
construct.
envision
these
will
open
new
opportunities
bioengineering
functional,
hierarchically
self-organized
engineered
tissues.
Journal of Biomedical Materials Research Part B Applied Biomaterials,
Journal Year:
2024,
Volume and Issue:
112(12)
Published: Nov. 18, 2024
ABSTRACT
Bone‐on‐a‐chip
(BOC)
models
that
based
on
microfluidic
technology
have
widely
applied
to
understand
bone
physiology
and
the
pathogenesis
of
related
diseases.
In
this
review,
we
provide
an
overview
biology
diseases,
explain
advantages
applications
in
construction
BOC
models,
summarize
their
progress
physiology,
pathology,
drug
development.
Finally,
discussed
problems
be
solved
future
directions
platforms,
so
as
a
reference
for
researchers
design
better
models.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2024,
Volume and Issue:
12
Published: Oct. 16, 2024
Kidney
disease
encompasses
a
wide
spectrum
of
conditions,
ranging
from
simple
infections
to
chronic
kidney
disease.
When
the
kidneys
are
unable
filter
blood
and
remove
waste
products,
these
abnormalities
can
lead
failure.
In
severe
cases
failure,
transplantation
is
considered
only
definitive
treatment.
Worldwide,
World
Health
Organization
(WHO)
repeatedly
emphasizes
importance
organ
donation
increasing
rates.
Many
countries
implement
national
programs
promote
culture
improve
patient
access
transplantation.
The
extent
which
this
procedure
performed
varies
across
influenced
by
several
factors,
including
volume
donation,
medical
infrastructure,
technology
health
policies.
However,
transplant
comes
with
challenges
problems
that
impact
its
success.
tissue
engineering
new
approach
shows
promise
for
repairing
replacing
damaged
tissue.
This
article
reviews
recent
advances
in
engineering,
focusing
on
engineered
structures
such
as
hydrogels,
electrospinning,
3D
bioprinting,
microfluidic
systems.
By
mimicking
extracellular
environment
kidney,
provide
suitable
conditions
growth
development
cells.
role
formation
vessels,
mimicry
functions
field
were
also
discussed.
results
study
show
has
high
potential
treating
diseases
reducing
need
achieve
clinical
application
technology,
further
research
required
biocompatibility,
vascularization
long-term
performance
tissues.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 1, 2024
Dynamic
growth
factor
presentation
influences
how
individual
endothelial
cells
assemble
into
complex
vascular
networks.
Here,
programmable
bioinks
are
developed
that
facilitate
dynamic
(VEGF)
to
guide
morphogenesis
within
3D-bioprinted
constructs.
Aptamer's
high
affinity
is
leveraged
for
rapid
VEGF
sequestration
in
spatially
confined
regions
and
utilized
aptamer-complementary
sequence
(CS)
hybridization
tune
release
kinetics
temporally,
days
after
bioprinting.
It
shown
spatial
resolution
of
bioink,
combined
with
CS-triggered
release,
significantly
the
alignment,
organization,
microvascular
networks
bioprinted
The
presence
aptamer-tethered
generation
instantaneous
gradients
upon
CS-triggering
restricted
hierarchical
network
formation
printed
aptamer
at
all
resolutions.
Network
properties
improved
as
decreased,
low-resolution
designs
yielding
highest
properties.
Specifically,
CS-treated
exhibited
significant
remodeling,
an
increase
vessel
density(1.35-fold),
branching
density(1.54-fold),
average
length(2.19-fold)
compared
non-treated
samples.
results
suggest
CS
acts
external
trigger
capable
inducing
time-controlled
changes
organization
alignment
on-demand
localized
a
construct.
envisioned
these
will
open
new
opportunities
bioengineering
functional,
hierarchically
self-organized
engineered
tissues.
