Controversies and insights into PTBP1-related astrocyte-neuron transdifferentiation: neuronal regeneration strategies for Parkinson’s and Alzheimer’s disease DOI Creative Commons

Simon McDowall,

Vaishali Bagda,

Stuart I. Hodgetts

et al.

Translational Neurodegeneration, Journal Year: 2024, Volume and Issue: 13(1)

Published: Dec. 3, 2024

Abstract Promising therapeutic strategies are being explored to replace or regenerate the neuronal populations that lost in patients with neurodegenerative disorders. Several research groups have attempted direct reprogramming of astrocytes into neurons by manipulating expression polypyrimidine tract-binding protein 1 (PTBP1) and claimed putative converted be functional, which led improved disease outcomes animal models several However, a few other studies reported data contradict these claims, raising doubt about whether PTBP1 suppression truly reprograms potential this approach. This review discusses recent advances regenerative therapeutics including stem cell transplantations for central nervous system disorders, particular focus on Parkinson’s Alzheimer’s diseases. We also provide perspective controversy considering astrocyte heterogeneity may key understanding discrepancy published studies, certain subpopulations glial cells more readily neurons.

Language: Английский

Controversies and insights into PTBP1-related astrocyte-neuron transdifferentiation: neuronal regeneration strategies for Parkinson’s and Alzheimer’s disease DOI Creative Commons

Simon McDowall,

Vaishali Bagda,

Stuart I. Hodgetts

et al.

Translational Neurodegeneration, Journal Year: 2024, Volume and Issue: 13(1)

Published: Dec. 3, 2024

Abstract Promising therapeutic strategies are being explored to replace or regenerate the neuronal populations that lost in patients with neurodegenerative disorders. Several research groups have attempted direct reprogramming of astrocytes into neurons by manipulating expression polypyrimidine tract-binding protein 1 (PTBP1) and claimed putative converted be functional, which led improved disease outcomes animal models several However, a few other studies reported data contradict these claims, raising doubt about whether PTBP1 suppression truly reprograms potential this approach. This review discusses recent advances regenerative therapeutics including stem cell transplantations for central nervous system disorders, particular focus on Parkinson’s Alzheimer’s diseases. We also provide perspective controversy considering astrocyte heterogeneity may key understanding discrepancy published studies, certain subpopulations glial cells more readily neurons.

Language: Английский

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