The impact of compression and confinement in tumor growth and progression: emerging concepts in cancer mechanobiology DOI Creative Commons

Allison McKenzie Johnson,

Charles Froman-Glover,

Akshitkumar M. Mistry

et al.

Frontiers in Materials, Journal Year: 2025, Volume and Issue: 12

Published: April 9, 2025

Cancer is one of the deadliest diseases despite aggressive therapeutics. This due in part to evolving tumor microenvironment (TME), which provide supportive cues that promote adaptation and progression. Emerging studies highlight significant role biophysical characteristics TME modulating all aspects cancer spread. With advance bioengineering platforms, deeper investigations into impact these features on progression are being conducted with a growing appreciation intratumoral compression underlie many changes. Intratumoral emerges early development increases magnitude as rapidly expands against itself its surrounding tissue. stress has effects both cells TME, including hypoxia, shear stress, extracellular matrix (ECM) remodeling, substrate stiffness. creates physically dense, pro-malignant environment can metastatic phenotypes spread but also present barriers for immune cell infiltration. review will analyze effect compressive cells, confined migration populations.

Language: Английский

An Update on the Clinical Status, Challenges, and Future Directions of Oncolytic Virotherapy for Malignant Gliomas DOI
Georgios M. Stergiopoulos, Susanna C. Concilio, Evanthia Galanis

et al.

Current Treatment Options in Oncology, Journal Year: 2024, Volume and Issue: 25(7), P. 952 - 991

Published: June 19, 2024

Language: Английский

Citations

6
The prognostic effect of mechanical, ultrastructural, and ECM signatures in glioblastoma core and rim DOI Creative Commons

Bradley Mahaffey,

Zachary P. Fowler,

Zoe Lung

et al.

APL Bioengineering, Journal Year: 2024, Volume and Issue: 8(3)

Published: June 24, 2024

Glioblastoma (GBM) is a highly invasive, aggressive brain cancer that carries median survival of 15 months and resistant to standard therapeutics. Recent studies have demonstrated intratumoral heterogeneity plays critical role in promoting resistance by mediating tumor adaptation through microenvironmental cues. GBM can be separated into two distinct regions—a core rim, which are thought drive specific aspects evolution. These differences progression regulated the diverse biomolecular biophysical signals these regions, but acellular characteristics remain poorly described. This study investigates mechanical ultrastructural extracellular matrix (ECM) patient-matched rim tissues. Seven samples one non-neoplastic control were analyzed using atomic force microscopy, scanning electron immunofluorescence imaging quantify mechanical, ultrastructural, ECM composition changes. The results reveal significant parameters between core, stiffer, denser, rich proteins hyaluronic acid tenascin-C when compared alterations intimately related prognostic effect with stiff, dense tissue correlating longer progression-free survival. findings new insights spatial microenvironment identify set may correlate patient prognosis. In long term, aid development strategies combat therapeutic resistance.

Language: Английский

Citations

4
The impact of compression and confinement in tumor growth and progression: emerging concepts in cancer mechanobiology DOI Creative Commons

Allison McKenzie Johnson,

Charles Froman-Glover,

Akshitkumar M. Mistry

et al.

Frontiers in Materials, Journal Year: 2025, Volume and Issue: 12

Published: April 9, 2025

Cancer is one of the deadliest diseases despite aggressive therapeutics. This due in part to evolving tumor microenvironment (TME), which provide supportive cues that promote adaptation and progression. Emerging studies highlight significant role biophysical characteristics TME modulating all aspects cancer spread. With advance bioengineering platforms, deeper investigations into impact these features on progression are being conducted with a growing appreciation intratumoral compression underlie many changes. Intratumoral emerges early development increases magnitude as rapidly expands against itself its surrounding tissue. stress has effects both cells TME, including hypoxia, shear stress, extracellular matrix (ECM) remodeling, substrate stiffness. creates physically dense, pro-malignant environment can metastatic phenotypes spread but also present barriers for immune cell infiltration. review will analyze effect compressive cells, confined migration populations.

Language: Английский

Citations

0