The Impact of Urodynamic Findings on Fatigue and Depression in People with Multiple Sclerosis DOI Creative Commons
Anke K. Jaekel, Julius Watzek, Jörn Nielsen

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(3), P. 601 - 601

Published: March 1, 2025

Background: Fatigue and depression are common symptoms of multiple sclerosis (MS) that severely impair quality life. The factors influencing both increasing interest for establishing therapeutic synergisms. Correlations between the neurogenic lower urinary tract dysfunction (NLUTD), fatigue, have been described, but impact pathological urodynamic study (UDS) findings has not investigated to date. Method: This retrospective, observational correlated UDS 274 people with MS (PwMS), prospectively collected February 2017 September 2021, scores on Scale Motor Cognitive Functions German version Centre Epidemiologic Studies Depression Scale. effects abnormal FSMC ADS were examined. Abnormal was defined as follows: first desire void (FDV) < 100 mL, strong 250 mL (SDV), sensation, detrusor overactivity, detrusor–sphincter dyssynergia, reduced cystometric bladder capacity (MCBC), compliance 20 mL/cm H2O (Clow). Results: PwMS Clow (mean difference 3.21, 95% CI 0.25; 6.17, p = 0.036) or FDV 2.61, 0.1; 5.12, 0.041) had significantly higher mean values than those without. MCBC (relative risk 1.06, 1.02; 1.1, 0.006) 0.004) an increased clinically relevant fatigue. No found depression. Conclusions: NLUTD fatigue in our retrospective study. assessment prospective longitudinal data regarding effect successfully treated is important utilising synergisms improved life PwMS.

Language: Английский

Depression and anxiety in multiple sclerosis. Review of a fatal combination DOI
K. A. Jellinger

Journal of Neural Transmission, Journal Year: 2024, Volume and Issue: 131(8), P. 847 - 869

Published: June 13, 2024

Language: Английский

Citations

5
Association of the Val66Met Polymorphism of the BDNF Gene with the Depression in a Mexican Population with Multiple Sclerosis DOI Creative Commons
Brenda Viridiana Rabago-Barajas, Miguel Ángel Macías-Islas, Ana Míriam Saldaña-Cruz

et al.

Life, Journal Year: 2025, Volume and Issue: 15(2), P. 213 - 213

Published: Jan. 31, 2025

Multiple sclerosis (MS) is a chronic, autoimmune pathology that affects the nervous system. It characterized by inflammatory lesions cause axonal damage with neurodegeneration. The signs and symptoms present in this include among others, psychiatric disorders. In MS, depression most frequent disorder, prevalence levels of 40 to 60%; date, unknown. brain-derived neurotrophic factor (BDNF) neurotrophin related neuroplasticity. single-nucleotide polymorphism Val66Met, encoded BDNF gene, has been associated various effects, including presence neuropsychiatric purpose our study was evaluate association between Val66Met MS patients. Study design, cases, controls: Mexican mestizo Patients diagnosed depression. without diagnosis. For depression, Beck Depression Inventory; for polymorphism, real-time PCR. No statistically significant differences were found sociodemographic disease variables case control groups. qPCR analysis showed 68% participants Val/Val wild-type homozygotes, 29% Val/Met heterozygotes, 3% Met/Met homozygotes. gene rs6265 5.6-fold increase probability cases compared controls. Polymorphism patients MS.

Language: Английский

Citations

0
Depression as a mediator between sensory processing sensitivity and prefrontal symptoms in Spanish adults DOI Creative Commons
Borja Costa-López, Nicolás Ruiz‐Robledillo, Oswaldo Moreno

et al.

Current Psychology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 8, 2025

Language: Английский

Citations

0
The Impact of Urodynamic Findings on Fatigue and Depression in People with Multiple Sclerosis DOI Creative Commons
Anke K. Jaekel, Julius Watzek, Jörn Nielsen

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(3), P. 601 - 601

Published: March 1, 2025

Background: Fatigue and depression are common symptoms of multiple sclerosis (MS) that severely impair quality life. The factors influencing both increasing interest for establishing therapeutic synergisms. Correlations between the neurogenic lower urinary tract dysfunction (NLUTD), fatigue, have been described, but impact pathological urodynamic study (UDS) findings has not investigated to date. Method: This retrospective, observational correlated UDS 274 people with MS (PwMS), prospectively collected February 2017 September 2021, scores on Scale Motor Cognitive Functions German version Centre Epidemiologic Studies Depression Scale. effects abnormal FSMC ADS were examined. Abnormal was defined as follows: first desire void (FDV) < 100 mL, strong 250 mL (SDV), sensation, detrusor overactivity, detrusor–sphincter dyssynergia, reduced cystometric bladder capacity (MCBC), compliance 20 mL/cm H2O (Clow). Results: PwMS Clow (mean difference 3.21, 95% CI 0.25; 6.17, p = 0.036) or FDV 2.61, 0.1; 5.12, 0.041) had significantly higher mean values than those without. MCBC (relative risk 1.06, 1.02; 1.1, 0.006) 0.004) an increased clinically relevant fatigue. No found depression. Conclusions: NLUTD fatigue in our retrospective study. assessment prospective longitudinal data regarding effect successfully treated is important utilising synergisms improved life PwMS.

Language: Английский

Citations

0